Hyperhomocysteinemia and changed plasma thiol redox status in chronic obstructive pulmonary disease
Andersson, Anders ; Ankerst, Jaro LU
; Lindgren, Arne
LU
; Larsson, Kerstin
and Hultberg, Björn
LU
(2001)
In Clinical Chemistry and Laboratory Medicine
39(3).
p.229-233
- Abstract
- Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmonary disease and in 29 healthy subjects. The purpose was to examine the influence of pro-oxidant activity caused by the lung disease on the metabolism of homocysteine and other plasma thiols. We observed a decreased concentration of reduced glutathione and a decreased ratio of reduced/total glutathione in the patients compared to the healthy individuals, which supports the hypothesis of an association between free radicals and pathogenesis in some lung diseases. We also observed an increased total plasma homocysteine. The influence of a possible extracellular pro-oxidant activity on the... (More)
- Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmonary disease and in 29 healthy subjects. The purpose was to examine the influence of pro-oxidant activity caused by the lung disease on the metabolism of homocysteine and other plasma thiols. We observed a decreased concentration of reduced glutathione and a decreased ratio of reduced/total glutathione in the patients compared to the healthy individuals, which supports the hypothesis of an association between free radicals and pathogenesis in some lung diseases. We also observed an increased total plasma homocysteine. The influence of a possible extracellular pro-oxidant activity on the concentration of total plasma homocysteine is discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1122316
- author
- Andersson, Anders
; Ankerst, Jaro
LU
; Lindgren, Arne
LU
; Larsson, Kerstin
and Hultberg, Björn
LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Chemistry and Laboratory Medicine
- volume
- 39
- issue
- 3
- pages
- 229 - 233
- publisher
- De Gruyter
- external identifiers
-
- pmid:11350020
- scopus:0035040446
- ISSN
- 1434-6621
- language
- English
- LU publication?
- yes
- id
- fd7c4a2b-9512-4e25-9e94-391501378a41 (old id 1122316)
- date added to LUP
- 2016-04-01 12:26:09
- date last changed
- 2024-01-08 20:24:52
@article{fd7c4a2b-9512-4e25-9e94-391501378a41,
abstract = {{Reduced and total homocysteine, cysteine, glutathione and cysteinylglycine in plasma were investigated in 19 patients with chronic obstructive pulmonary disease and in 29 healthy subjects. The purpose was to examine the influence of pro-oxidant activity caused by the lung disease on the metabolism of homocysteine and other plasma thiols. We observed a decreased concentration of reduced glutathione and a decreased ratio of reduced/total glutathione in the patients compared to the healthy individuals, which supports the hypothesis of an association between free radicals and pathogenesis in some lung diseases. We also observed an increased total plasma homocysteine. The influence of a possible extracellular pro-oxidant activity on the concentration of total plasma homocysteine is discussed.}},
author = {{Andersson, Anders and Ankerst, Jaro and Lindgren, Arne and Larsson, Kerstin and Hultberg, Björn}},
issn = {{1434-6621}},
language = {{eng}},
number = {{3}},
pages = {{229--233}},
publisher = {{De Gruyter}},
series = {{Clinical Chemistry and Laboratory Medicine}},
title = {{Hyperhomocysteinemia and changed plasma thiol redox status in chronic obstructive pulmonary disease}},
volume = {{39}},
year = {{2001}},
}