Effects of aluminium chloride added to common patch test substances
(2023) In Contact Dermatitis 88(6). p.456-462- Abstract
Background: A modulating effect of aluminium regarding type IV reactions might exist but has not been further investigated. Objectives: The aim of this study was to investigate the effect on patch test reactions when adding aluminium chloride hexahydrate (Al-Cl) to common test preparations. Materials and methods: Al-Cl in different concentrations was added to nickel sulphate 15.0% aqua (Ni), methylisothiazolinone 0.2% aqua (MI) and fragrance mix I 10.0% aqua/ethanol (FM I). The Ni preparations were tested in 120 consecutive patients. MI and FM I were tested in participants known to have contact allergy to the respective allergen. McNemar's test was used to decide which Ni preparation had the highest sensitivity. Wilcoxon signed-rank... (More)
Background: A modulating effect of aluminium regarding type IV reactions might exist but has not been further investigated. Objectives: The aim of this study was to investigate the effect on patch test reactions when adding aluminium chloride hexahydrate (Al-Cl) to common test preparations. Materials and methods: Al-Cl in different concentrations was added to nickel sulphate 15.0% aqua (Ni), methylisothiazolinone 0.2% aqua (MI) and fragrance mix I 10.0% aqua/ethanol (FM I). The Ni preparations were tested in 120 consecutive patients. MI and FM I were tested in participants known to have contact allergy to the respective allergen. McNemar's test was used to decide which Ni preparation had the highest sensitivity. Wilcoxon signed-rank test was used to calculate pairwise comparison in summarized test score for the preparations with MI and FM I. Results: Adding Al-Cl 20.0%/30.0% to Ni identified twice as many patients with contact allergy to nickel compared to Ni without Al-Cl. Adding Al-Cl 20.0%/10.0% to MI, decreased the patch test reactivity compared to MI without Al-Cl. No differences in patch reactivity were noticed when adding Al-Cl to FM I. Conclusion: Al-Cl 20.0% or 30.0% seems to enhance the patch test reactivity to Ni 15.0% aqua.
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- author
- Comstedt, Lisbeth Rosholm LU ; Siemund, Ingrid LU ; Dahlin, Jakob LU ; Bruze, Magnus LU and Svedman, Cecilia LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adjuvants, allergic contact dermatitis, irritants, mixes with aluminium, patch testing with metals, sensitivity, specificity
- in
- Contact Dermatitis
- volume
- 88
- issue
- 6
- pages
- 7 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85150649392
- pmid:36840428
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.14299
- language
- English
- LU publication?
- yes
- id
- 1131cf5c-3333-453e-a8d0-be663e5dafbc
- date added to LUP
- 2023-05-29 13:17:20
- date last changed
- 2024-08-10 08:20:30
@article{1131cf5c-3333-453e-a8d0-be663e5dafbc, abstract = {{<p>Background: A modulating effect of aluminium regarding type IV reactions might exist but has not been further investigated. Objectives: The aim of this study was to investigate the effect on patch test reactions when adding aluminium chloride hexahydrate (Al-Cl) to common test preparations. Materials and methods: Al-Cl in different concentrations was added to nickel sulphate 15.0% aqua (Ni), methylisothiazolinone 0.2% aqua (MI) and fragrance mix I 10.0% aqua/ethanol (FM I). The Ni preparations were tested in 120 consecutive patients. MI and FM I were tested in participants known to have contact allergy to the respective allergen. McNemar's test was used to decide which Ni preparation had the highest sensitivity. Wilcoxon signed-rank test was used to calculate pairwise comparison in summarized test score for the preparations with MI and FM I. Results: Adding Al-Cl 20.0%/30.0% to Ni identified twice as many patients with contact allergy to nickel compared to Ni without Al-Cl. Adding Al-Cl 20.0%/10.0% to MI, decreased the patch test reactivity compared to MI without Al-Cl. No differences in patch reactivity were noticed when adding Al-Cl to FM I. Conclusion: Al-Cl 20.0% or 30.0% seems to enhance the patch test reactivity to Ni 15.0% aqua.</p>}}, author = {{Comstedt, Lisbeth Rosholm and Siemund, Ingrid and Dahlin, Jakob and Bruze, Magnus and Svedman, Cecilia}}, issn = {{0105-1873}}, keywords = {{adjuvants; allergic contact dermatitis; irritants; mixes with aluminium; patch testing with metals; sensitivity; specificity}}, language = {{eng}}, number = {{6}}, pages = {{456--462}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Effects of aluminium chloride added to common patch test substances}}, url = {{http://dx.doi.org/10.1111/cod.14299}}, doi = {{10.1111/cod.14299}}, volume = {{88}}, year = {{2023}}, }