Parity in relation to survival following breast cancer.
(2009) In European Journal of Surgical Oncology 35. p.702-708- Abstract
- AIM: The present study examines the association between parity and survival following breast cancer diagnosis. METHODS: Medical records of 4453 women diagnosed with breast cancer in Malmö, Sweden, between 1961 and 1991 were analysed. All women were followed until 31 December 2003, using the Swedish Cause-of-Death Registry. Breast cancer specific mortality rate was calculated in different levels of parity. Corresponding relative risks, with 95% confidence intervals (CI), were obtained using Cox's proportional hazards analysis. All analyses were adjusted for potential prognostic factors and stratified for age, menopausal status and diagnostic period. RESULTS: As compared to women with one child, nulliparity (RR 1.27: 95% CI 1.09-1.47), and... (More)
- AIM: The present study examines the association between parity and survival following breast cancer diagnosis. METHODS: Medical records of 4453 women diagnosed with breast cancer in Malmö, Sweden, between 1961 and 1991 were analysed. All women were followed until 31 December 2003, using the Swedish Cause-of-Death Registry. Breast cancer specific mortality rate was calculated in different levels of parity. Corresponding relative risks, with 95% confidence intervals (CI), were obtained using Cox's proportional hazards analysis. All analyses were adjusted for potential prognostic factors and stratified for age, menopausal status and diagnostic period. RESULTS: As compared to women with one child, nulliparity (RR 1.27: 95% CI 1.09-1.47), and high parity (four or more children) (1.49: 1.20-1.85) were positively associated with a high mortality from breast cancer. When adjusted for potential confounders, the association was only statistically significant for high parity (1.33: 1.07-1.66). In the analyses stratified on age and menopausal status, there was a similar positive association between high parity and breast cancer death in all strata, although only statistically significant among women older than 45years of age or postmenopausal. Nulliparity was associated with breast cancer death in women that were younger than 45years of age (1.28: 0.79-2.09) or premenopausal (1.30: 0.95-1.80), but these associations did not reach statistical significance. There was no association between nulliparity and breast cancer death in women older than 45years of age or postmenopausal. All associations were similar in analyses stratified for diagnostic period. CONCLUSION: Women with four or more children have a poor breast cancer survival as compared to women with one child. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1153970
- author
- Butt, Salma LU ; Borgquist, Signe LU ; Garne, J P ; Landberg, Göran LU ; Tengrup, Ingrid LU ; Olsson, A and Manjer, Jonas LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Surgical Oncology
- volume
- 35
- pages
- 702 - 708
- publisher
- Elsevier
- external identifiers
-
- wos:000267301700005
- pmid:18490128
- scopus:67349176099
- pmid:18490128
- ISSN
- 1532-2157
- DOI
- 10.1016/j.ejso.2008.03.017
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Internal Medicine Research Unit (013242520), Pathology (Malmö) (013031000), Emergency medicine/Medicine/Surgery (013240200)
- id
- b30811e9-7ece-4802-b6b4-3e1857993b79 (old id 1153970)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18490128?dopt=Abstract
- date added to LUP
- 2016-04-04 07:55:35
- date last changed
- 2022-01-29 02:49:03
@article{b30811e9-7ece-4802-b6b4-3e1857993b79,
abstract = {{AIM: The present study examines the association between parity and survival following breast cancer diagnosis. METHODS: Medical records of 4453 women diagnosed with breast cancer in Malmö, Sweden, between 1961 and 1991 were analysed. All women were followed until 31 December 2003, using the Swedish Cause-of-Death Registry. Breast cancer specific mortality rate was calculated in different levels of parity. Corresponding relative risks, with 95% confidence intervals (CI), were obtained using Cox's proportional hazards analysis. All analyses were adjusted for potential prognostic factors and stratified for age, menopausal status and diagnostic period. RESULTS: As compared to women with one child, nulliparity (RR 1.27: 95% CI 1.09-1.47), and high parity (four or more children) (1.49: 1.20-1.85) were positively associated with a high mortality from breast cancer. When adjusted for potential confounders, the association was only statistically significant for high parity (1.33: 1.07-1.66). In the analyses stratified on age and menopausal status, there was a similar positive association between high parity and breast cancer death in all strata, although only statistically significant among women older than 45years of age or postmenopausal. Nulliparity was associated with breast cancer death in women that were younger than 45years of age (1.28: 0.79-2.09) or premenopausal (1.30: 0.95-1.80), but these associations did not reach statistical significance. There was no association between nulliparity and breast cancer death in women older than 45years of age or postmenopausal. All associations were similar in analyses stratified for diagnostic period. CONCLUSION: Women with four or more children have a poor breast cancer survival as compared to women with one child.}},
author = {{Butt, Salma and Borgquist, Signe and Garne, J P and Landberg, Göran and Tengrup, Ingrid and Olsson, A and Manjer, Jonas}},
issn = {{1532-2157}},
language = {{eng}},
pages = {{702--708}},
publisher = {{Elsevier}},
series = {{European Journal of Surgical Oncology}},
title = {{Parity in relation to survival following breast cancer.}},
url = {{http://dx.doi.org/10.1016/j.ejso.2008.03.017}},
doi = {{10.1016/j.ejso.2008.03.017}},
volume = {{35}},
year = {{2009}},
}