Inflammatory markers in matched plasma and cerebrospinal fluid from patients with Alzheimer's disease.
(2003) In Dementia and Geriatric Cognitive Disorders 16(3). p.136-144- Abstract
- It has been suggested that a number of molecules associated with inflammation are involved in the pathogenesis of Alzheimer's disease (AD). We measured the levels of alpha1-antichymotrypsin (ACT), alpha1-antitrypsin (AAT), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and oxidised low-density lipoprotein (oxLDL) in matched cerebrospinal fluid (CSF) and plasma of 141 patients with probable AD. We found a significant relationship between CSF and plasma levels of ACT (r = 0.4, p < 0.001), IL-6 (r = 0.74, p < 0.001), MCP-1 (r = 0.71, p < 0.001), and a borderline relationship between CSF and plasma oxLDL (r = 0.22, p < 0.05). In addition, linear regression analysis revealed a positive correlation between levels of... (More)
- It has been suggested that a number of molecules associated with inflammation are involved in the pathogenesis of Alzheimer's disease (AD). We measured the levels of alpha1-antichymotrypsin (ACT), alpha1-antitrypsin (AAT), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and oxidised low-density lipoprotein (oxLDL) in matched cerebrospinal fluid (CSF) and plasma of 141 patients with probable AD. We found a significant relationship between CSF and plasma levels of ACT (r = 0.4, p < 0.001), IL-6 (r = 0.74, p < 0.001), MCP-1 (r = 0.71, p < 0.001), and a borderline relationship between CSF and plasma oxLDL (r = 0.22, p < 0.05). In addition, linear regression analysis revealed a positive correlation between levels of CSF-ACT and oxLDL (p < 0.001), but an inverse relation between levels of CSF ACT, CSF AAT and MCP-1 (p < 0.001). A significant correlation was also found between levels of CSF ACT, oxLDL and the ratio of CSF to serum albumin, which is used as a measure of the blood-brain barrier function. Our data extend previous reports regarding the inflammatory markers in the plasma and CSF of patients with AD and provide good evidence that levels of ACT, IL-6, MCP-1 and oxLDL in plasma and CSF might be candidates as biomarkers for monitoring the inflammatory process in AD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/115658
- author
- Sun, Yongxin LU ; Minthon, Lennart LU ; Wallmark, A ; Warkentin, Siegbert LU ; Blennow, K and Janciauskiene, Sabina LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Dementia and Geriatric Cognitive Disorders
- volume
- 16
- issue
- 3
- pages
- 136 - 144
- publisher
- Karger
- external identifiers
-
- pmid:12826739
- wos:000184152400004
- scopus:0038115686
- ISSN
- 1420-8008
- DOI
- 10.1159/000071001
- language
- English
- LU publication?
- yes
- id
- 3d89dc13-48d0-4fe4-9d31-95f1492a59dc (old id 115658)
- date added to LUP
- 2016-04-01 12:15:54
- date last changed
- 2022-03-28 22:29:44
@article{3d89dc13-48d0-4fe4-9d31-95f1492a59dc, abstract = {{It has been suggested that a number of molecules associated with inflammation are involved in the pathogenesis of Alzheimer's disease (AD). We measured the levels of alpha1-antichymotrypsin (ACT), alpha1-antitrypsin (AAT), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and oxidised low-density lipoprotein (oxLDL) in matched cerebrospinal fluid (CSF) and plasma of 141 patients with probable AD. We found a significant relationship between CSF and plasma levels of ACT (r = 0.4, p < 0.001), IL-6 (r = 0.74, p < 0.001), MCP-1 (r = 0.71, p < 0.001), and a borderline relationship between CSF and plasma oxLDL (r = 0.22, p < 0.05). In addition, linear regression analysis revealed a positive correlation between levels of CSF-ACT and oxLDL (p < 0.001), but an inverse relation between levels of CSF ACT, CSF AAT and MCP-1 (p < 0.001). A significant correlation was also found between levels of CSF ACT, oxLDL and the ratio of CSF to serum albumin, which is used as a measure of the blood-brain barrier function. Our data extend previous reports regarding the inflammatory markers in the plasma and CSF of patients with AD and provide good evidence that levels of ACT, IL-6, MCP-1 and oxLDL in plasma and CSF might be candidates as biomarkers for monitoring the inflammatory process in AD.}}, author = {{Sun, Yongxin and Minthon, Lennart and Wallmark, A and Warkentin, Siegbert and Blennow, K and Janciauskiene, Sabina}}, issn = {{1420-8008}}, language = {{eng}}, number = {{3}}, pages = {{136--144}}, publisher = {{Karger}}, series = {{Dementia and Geriatric Cognitive Disorders}}, title = {{Inflammatory markers in matched plasma and cerebrospinal fluid from patients with Alzheimer's disease.}}, url = {{http://dx.doi.org/10.1159/000071001}}, doi = {{10.1159/000071001}}, volume = {{16}}, year = {{2003}}, }