Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt.
(2009) In Journal of Affective Disorders Jun 2. p.179-182- Abstract
- BACKGROUND: The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms. METHODS: Ten patients took part in lumbar punctures and psychiatric evaluations in conjunction to a suicide attempt and after 6 and 12 months. We measured CSF-orexin and CART using radioimmunoassays. RESULTS: Mean CSF-orexin was significantly higher at the first and second follow-up than at the suicide attempt. In contrast, mean CSF-CART did not differ over time. Total SUAS scores, as well as ratings of CPRS item 66 (global illness)... (More)
- BACKGROUND: The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms. METHODS: Ten patients took part in lumbar punctures and psychiatric evaluations in conjunction to a suicide attempt and after 6 and 12 months. We measured CSF-orexin and CART using radioimmunoassays. RESULTS: Mean CSF-orexin was significantly higher at the first and second follow-up than at the suicide attempt. In contrast, mean CSF-CART did not differ over time. Total SUAS scores, as well as ratings of CPRS item 66 (global illness) were significantly lower at follow-up. At one year, there was a significant negative correlation between the change in CSF-orexin and the change in total SUAS score. LIMITATIONS: The number of patients who participated was relatively small. CONCLUSIONS: Our results support the hypothesis that orexin is involved in psychiatric symptomatology. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1169096
- author
- Brundin, Lena LU ; Björkqvist, Maria LU ; Träskman Bendz, Lil LU and Petersén, Åsa LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Affective Disorders
- volume
- Jun 2
- pages
- 179 - 182
- publisher
- Elsevier
- external identifiers
-
- wos:000263007500020
- pmid:18533274
- scopus:58149093295
- ISSN
- 1573-2517
- DOI
- 10.1016/j.jad.2008.04.011
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Psychiatry (Lund) (013303000), Translational Neuroendocrinology (013210010), Neuronal Survival (013212041)
- id
- c624a9e8-5ad1-4e00-bd18-0bc393484599 (old id 1169096)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18533274?dopt=Abstract
- date added to LUP
- 2016-04-04 07:01:01
- date last changed
- 2023-09-05 10:26:45
@article{c624a9e8-5ad1-4e00-bd18-0bc393484599, abstract = {{BACKGROUND: The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms. METHODS: Ten patients took part in lumbar punctures and psychiatric evaluations in conjunction to a suicide attempt and after 6 and 12 months. We measured CSF-orexin and CART using radioimmunoassays. RESULTS: Mean CSF-orexin was significantly higher at the first and second follow-up than at the suicide attempt. In contrast, mean CSF-CART did not differ over time. Total SUAS scores, as well as ratings of CPRS item 66 (global illness) were significantly lower at follow-up. At one year, there was a significant negative correlation between the change in CSF-orexin and the change in total SUAS score. LIMITATIONS: The number of patients who participated was relatively small. CONCLUSIONS: Our results support the hypothesis that orexin is involved in psychiatric symptomatology.}}, author = {{Brundin, Lena and Björkqvist, Maria and Träskman Bendz, Lil and Petersén, Åsa}}, issn = {{1573-2517}}, language = {{eng}}, pages = {{179--182}}, publisher = {{Elsevier}}, series = {{Journal of Affective Disorders}}, title = {{Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt.}}, url = {{http://dx.doi.org/10.1016/j.jad.2008.04.011}}, doi = {{10.1016/j.jad.2008.04.011}}, volume = {{Jun 2}}, year = {{2009}}, }