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Cyclodextrin-surfactant complex: A new route in DNA decompaction

Gonzalez Perez, Alfredo LU ; Dias, Rita LU ; Nylander, Tommy LU and Lindman, Björn LU (2008) In Biomacromolecules 9(3). p.772-775
Abstract
In the present work, we show a new approach for decompaction of DNA-cationic surfactant complexes, e.g., lipoplexes, by using beta-cyclodextrin (beta-CD). The DNA decompaction was achieved by dissolving the surfactant aggregates in the complex by making use of the high affinity between the beta-CD and the free surfactant in solution. The results from fluorescence microscopy and adiabatic compressibility measurements indicate that coils and globules do not coexist. The reported procedure using beta-CD is an efficient way to decompact DNA surfactant complexes because the association constant of surfactants with beta-CD is large. The surfactant's interaction with beta-CD is specific and the nonspecific interaction between beta-CD and... (More)
In the present work, we show a new approach for decompaction of DNA-cationic surfactant complexes, e.g., lipoplexes, by using beta-cyclodextrin (beta-CD). The DNA decompaction was achieved by dissolving the surfactant aggregates in the complex by making use of the high affinity between the beta-CD and the free surfactant in solution. The results from fluorescence microscopy and adiabatic compressibility measurements indicate that coils and globules do not coexist. The reported procedure using beta-CD is an efficient way to decompact DNA surfactant complexes because the association constant of surfactants with beta-CD is large. The surfactant's interaction with beta-CD is specific and the nonspecific interaction between beta-CD and biological interfaces is small. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomacromolecules
volume
9
issue
3
pages
772 - 775
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000253926400003
  • scopus:41949138209
  • pmid:18257531
ISSN
1526-4602
DOI
10.1021/bm7012907
language
English
LU publication?
yes
id
3ac813a2-161d-435e-8561-76583edf4d4e (old id 1191576)
date added to LUP
2016-04-01 12:37:37
date last changed
2022-01-27 07:39:27
@article{3ac813a2-161d-435e-8561-76583edf4d4e,
  abstract     = {{In the present work, we show a new approach for decompaction of DNA-cationic surfactant complexes, e.g., lipoplexes, by using beta-cyclodextrin (beta-CD). The DNA decompaction was achieved by dissolving the surfactant aggregates in the complex by making use of the high affinity between the beta-CD and the free surfactant in solution. The results from fluorescence microscopy and adiabatic compressibility measurements indicate that coils and globules do not coexist. The reported procedure using beta-CD is an efficient way to decompact DNA surfactant complexes because the association constant of surfactants with beta-CD is large. The surfactant's interaction with beta-CD is specific and the nonspecific interaction between beta-CD and biological interfaces is small.}},
  author       = {{Gonzalez Perez, Alfredo and Dias, Rita and Nylander, Tommy and Lindman, Björn}},
  issn         = {{1526-4602}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{772--775}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Biomacromolecules}},
  title        = {{Cyclodextrin-surfactant complex: A new route in DNA decompaction}},
  url          = {{http://dx.doi.org/10.1021/bm7012907}},
  doi          = {{10.1021/bm7012907}},
  volume       = {{9}},
  year         = {{2008}},
}