Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data.

Robolge, Lenora LU ; Gerdhem, Paul LU ; Obrant, Karl LU and Ivaska, Kaisa LU (2009) In Osteoporosis International 20(7). p.1225-1232
Abstract
Associations between bone turnover markers and calcaneal ultrasound (quantitative ultrasound, QUS) were studied in a population-based sample of 810 elderly women. Baseline bone turnover markers correlated with baseline QUS as well as with 5-year prospective changes in QUS. INTRODUCTION: Bone turnover markers are associated with areal bone mineral density, but the knowledge on the association with QUS is limited. METHODS: Eight hundred ten women, all 75 years old, were investigated at baseline. Five hundred six completed a 5-year follow-up. Bone turnover markers and calcaneal QUS [speed of sound (SoS), broadband ultrasound attenuation (BUA), stiffness] were investigated at baseline. QUS was investigated at follow-up. RESULTS: All bone... (More)
Associations between bone turnover markers and calcaneal ultrasound (quantitative ultrasound, QUS) were studied in a population-based sample of 810 elderly women. Baseline bone turnover markers correlated with baseline QUS as well as with 5-year prospective changes in QUS. INTRODUCTION: Bone turnover markers are associated with areal bone mineral density, but the knowledge on the association with QUS is limited. METHODS: Eight hundred ten women, all 75 years old, were investigated at baseline. Five hundred six completed a 5-year follow-up. Bone turnover markers and calcaneal QUS [speed of sound (SoS), broadband ultrasound attenuation (BUA), stiffness] were investigated at baseline. QUS was investigated at follow-up. RESULTS: All bone turnover markers were correlated with baseline QUS [standardized regression (Beta(std)) values from -0.07, p < 0.05 to -0.23, p < 0.001], with the exception of bone-specific alkaline phosphatase (S-Bone ALP) which was not correlated with BUA and stiffness index. When the correlations between baseline bone turnover markers and 5-year changes in QUS were analyzed, three serum osteocalcins were correlated with changes of SoS and stiffness index (Beta(std) = -0.11, p < 0.05 to -0.17, p < 0.001). Also S-CTX-I correlated with changes of SoS and stiffness index (Beta(std) = -0.10 and -0.09, respectively, p < 0.05). S-TRACP5b, urinary deoxypyridinoline/crea, and U-MidOC/crea correlated with changes of SoS (Beta(std) = -0.10 and p < 0.05 for all). S-Bone ALP did not correlate with change of QUS. None of the bone turnover markers correlated with changes of BUA. CONCLUSIONS: Bone turnover markers correlate with concomitantly assessed QUS as well as with longitudinal change in QUS. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Osteoporosis International
volume
20
issue
7
pages
1225 - 1232
publisher
Springer
external identifiers
  • wos:000266665800015
  • pmid:18949532
  • scopus:67349239700
  • pmid:18949532
ISSN
1433-2965
DOI
10.1007/s00198-008-0769-x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300), Clinical and Molecular Osteoporosis Research Unit (013242930)
id
f13f6bc5-e410-4ba8-a3c6-dc7ef83c5f31 (old id 1261998)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18949532?dopt=Abstract
date added to LUP
2016-04-01 13:09:23
date last changed
2022-02-19 03:18:25
@article{f13f6bc5-e410-4ba8-a3c6-dc7ef83c5f31,
  abstract     = {{Associations between bone turnover markers and calcaneal ultrasound (quantitative ultrasound, QUS) were studied in a population-based sample of 810 elderly women. Baseline bone turnover markers correlated with baseline QUS as well as with 5-year prospective changes in QUS. INTRODUCTION: Bone turnover markers are associated with areal bone mineral density, but the knowledge on the association with QUS is limited. METHODS: Eight hundred ten women, all 75 years old, were investigated at baseline. Five hundred six completed a 5-year follow-up. Bone turnover markers and calcaneal QUS [speed of sound (SoS), broadband ultrasound attenuation (BUA), stiffness] were investigated at baseline. QUS was investigated at follow-up. RESULTS: All bone turnover markers were correlated with baseline QUS [standardized regression (Beta(std)) values from -0.07, p &lt; 0.05 to -0.23, p &lt; 0.001], with the exception of bone-specific alkaline phosphatase (S-Bone ALP) which was not correlated with BUA and stiffness index. When the correlations between baseline bone turnover markers and 5-year changes in QUS were analyzed, three serum osteocalcins were correlated with changes of SoS and stiffness index (Beta(std) = -0.11, p &lt; 0.05 to -0.17, p &lt; 0.001). Also S-CTX-I correlated with changes of SoS and stiffness index (Beta(std) = -0.10 and -0.09, respectively, p &lt; 0.05). S-TRACP5b, urinary deoxypyridinoline/crea, and U-MidOC/crea correlated with changes of SoS (Beta(std) = -0.10 and p &lt; 0.05 for all). S-Bone ALP did not correlate with change of QUS. None of the bone turnover markers correlated with changes of BUA. CONCLUSIONS: Bone turnover markers correlate with concomitantly assessed QUS as well as with longitudinal change in QUS.}},
  author       = {{Robolge, Lenora and Gerdhem, Paul and Obrant, Karl and Ivaska, Kaisa}},
  issn         = {{1433-2965}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1225--1232}},
  publisher    = {{Springer}},
  series       = {{Osteoporosis International}},
  title        = {{Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data.}},
  url          = {{http://dx.doi.org/10.1007/s00198-008-0769-x}},
  doi          = {{10.1007/s00198-008-0769-x}},
  volume       = {{20}},
  year         = {{2009}},
}