Cigarette smoking leads to reduced relaxant responses of the cutaneous microcirculation.
(2008) In Vascular Health and Risk Management 4(3). p.699-704- Abstract
- BACKGROUND: Smoking is a major risk factor for cardiovascular disease. The present study was undertaken to examine if cigarette smoking translates into reduced relaxant responses of the peripheral microcirculation. METHODS: The cutaneous forearm blood flow was measured by laser Doppler flowmetry. The vasodilator response to the iontophorectic administration of acetylcholine (ACh), acting via an endothelial mechanism, and sodium nitroprusside (SNP), and acting via a smooth muscle mechanism were studied. The study population consisted of 17 nonsmokers and 17 current smokers (mean age 64+/-2 years, 13 females and 4 males) in each matched group. RESULTS: There was no difference between the groups in baseline characteristics or in basal flow.... (More)
- BACKGROUND: Smoking is a major risk factor for cardiovascular disease. The present study was undertaken to examine if cigarette smoking translates into reduced relaxant responses of the peripheral microcirculation. METHODS: The cutaneous forearm blood flow was measured by laser Doppler flowmetry. The vasodilator response to the iontophorectic administration of acetylcholine (ACh), acting via an endothelial mechanism, and sodium nitroprusside (SNP), and acting via a smooth muscle mechanism were studied. The study population consisted of 17 nonsmokers and 17 current smokers (mean age 64+/-2 years, 13 females and 4 males) in each matched group. RESULTS: There was no difference between the groups in baseline characteristics or in basal flow. Smokers showed however significantly reduced responses to both ACh (mean +/- SEM, from 973+/-137% in nonsmokers to 651+/-114% in smokers, p<0.05) and SNP (from 575+/-111% in nonsmokers to 355+/-83% in smokers, p<0.05). The response to the local heating (44 degrees C) was reduced in smokers (from 1188+/-215% in nonsmokers to 714+/-107% in smokers, p<0.01). In addition, there was no difference between men and women within the groups. CONCLUSIONS: The data show that cigarette smoking results in reduced peripheral microvascular responses to both endothelial and smooth muscle cell stimulation in healthy subjects, suggesting a generalized microvascular vasomotor function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1262646
- author
- Edvinsson, MarieLouise LU ; Andersson, Sven LU ; Xu, Cang-Bao LU and Edvinsson, Lars LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Vasodilation: physiology, Smoking: physiopathology, Smoking: adverse effects, Skin: blood supply, Microcirculation: physiology, Acetylcholine: pharmacology, Vascular: physiopathology, Endothelium
- in
- Vascular Health and Risk Management
- volume
- 4
- issue
- 3
- pages
- 699 - 704
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- pmid:18827920
- scopus:47849086521
- ISSN
- 1178-2048
- language
- English
- LU publication?
- yes
- id
- be4d42bb-cb76-4fee-a5e7-7151fc17c292 (old id 1262646)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18827920?dopt=Abstract
- date added to LUP
- 2016-04-04 08:12:32
- date last changed
- 2024-01-12 03:59:45
@article{be4d42bb-cb76-4fee-a5e7-7151fc17c292,
abstract = {{BACKGROUND: Smoking is a major risk factor for cardiovascular disease. The present study was undertaken to examine if cigarette smoking translates into reduced relaxant responses of the peripheral microcirculation. METHODS: The cutaneous forearm blood flow was measured by laser Doppler flowmetry. The vasodilator response to the iontophorectic administration of acetylcholine (ACh), acting via an endothelial mechanism, and sodium nitroprusside (SNP), and acting via a smooth muscle mechanism were studied. The study population consisted of 17 nonsmokers and 17 current smokers (mean age 64+/-2 years, 13 females and 4 males) in each matched group. RESULTS: There was no difference between the groups in baseline characteristics or in basal flow. Smokers showed however significantly reduced responses to both ACh (mean +/- SEM, from 973+/-137% in nonsmokers to 651+/-114% in smokers, p<0.05) and SNP (from 575+/-111% in nonsmokers to 355+/-83% in smokers, p<0.05). The response to the local heating (44 degrees C) was reduced in smokers (from 1188+/-215% in nonsmokers to 714+/-107% in smokers, p<0.01). In addition, there was no difference between men and women within the groups. CONCLUSIONS: The data show that cigarette smoking results in reduced peripheral microvascular responses to both endothelial and smooth muscle cell stimulation in healthy subjects, suggesting a generalized microvascular vasomotor function.}},
author = {{Edvinsson, MarieLouise and Andersson, Sven and Xu, Cang-Bao and Edvinsson, Lars}},
issn = {{1178-2048}},
keywords = {{Vasodilation: physiology; Smoking: physiopathology; Smoking: adverse effects; Skin: blood supply; Microcirculation: physiology; Acetylcholine: pharmacology; Vascular: physiopathology; Endothelium}},
language = {{eng}},
number = {{3}},
pages = {{699--704}},
publisher = {{Dove Medical Press Ltd.}},
series = {{Vascular Health and Risk Management}},
title = {{Cigarette smoking leads to reduced relaxant responses of the cutaneous microcirculation.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/18827920?dopt=Abstract}},
volume = {{4}},
year = {{2008}},
}