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Maternal Epstein-Barr virus and cytomegalovirus infections and risk of testicular cancer in the offspring: a nested case-control study

Holl, Katsiaryna ; Surcel, Helja-Marja ; Koskela, Pentti ; Dillner, Joakim LU ; Hallmans, Goran ; Wadell, Goran ; Kaasila, Marjo ; Olafsdottir, Gudridur H. ; Ogmundsdottir, Helga M. and Pukkala, Eero , et al. (2008) In APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 116(9). p.816-822
Abstract
During recent decades the incidence of testicular cancer (TC) has increased rapidly around the world. Associated exogenous etiological factors might therefore be identifiable. We performed a case-control study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of congenital or neonatal infections with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) as risk factors of TC in the offspring. For each case-index mother pair, three or four matched control-control mother pairs were identified using national population registries. First trimester sera were retrieved from the index mothers of 66 TC cases and 258 matched control mothers and were tested for antibodies to EBV... (More)
During recent decades the incidence of testicular cancer (TC) has increased rapidly around the world. Associated exogenous etiological factors might therefore be identifiable. We performed a case-control study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of congenital or neonatal infections with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) as risk factors of TC in the offspring. For each case-index mother pair, three or four matched control-control mother pairs were identified using national population registries. First trimester sera were retrieved from the index mothers of 66 TC cases and 258 matched control mothers and were tested for antibodies to EBV and CMV. High level of maternal EBV IgG antibodies was associated with significantly increased risk of TC in the offspring (odds ratio (OR) 2.50; 95% confidence interval (CI) 1.15, 5.40), especially with risk of non-seminoma TC (OR, 2.73: 95% CI, 1.25, 5.99) and non-seminoma TC diagnosed under 8 years of age(OR, 2.72; 95% CI, 1.05, 7.04). In contrast, offspring of CMV IgG-seropositive mothers had a decreased risk of TC diagnosed under 8 years of age (OR, 0.35; 95% CI, 0.14, 0.89). Our results suggest that EBV and CMV infections may be associated with TC. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
testicular, cytomegalovirus, maternal infection, Epstein-Barr virus, cancer, offspring
in
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
volume
116
issue
9
pages
816 - 822
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000259927700007
  • scopus:57349099167
ISSN
1600-0463
DOI
10.1111/j.1600-0463.2008.00983.x
language
English
LU publication?
yes
id
34a1316f-b3d9-49d1-b006-2e8e4997acd7 (old id 1286886)
date added to LUP
2016-04-01 12:33:24
date last changed
2022-01-27 06:44:03
@article{34a1316f-b3d9-49d1-b006-2e8e4997acd7,
  abstract     = {{During recent decades the incidence of testicular cancer (TC) has increased rapidly around the world. Associated exogenous etiological factors might therefore be identifiable. We performed a case-control study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of congenital or neonatal infections with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) as risk factors of TC in the offspring. For each case-index mother pair, three or four matched control-control mother pairs were identified using national population registries. First trimester sera were retrieved from the index mothers of 66 TC cases and 258 matched control mothers and were tested for antibodies to EBV and CMV. High level of maternal EBV IgG antibodies was associated with significantly increased risk of TC in the offspring (odds ratio (OR) 2.50; 95% confidence interval (CI) 1.15, 5.40), especially with risk of non-seminoma TC (OR, 2.73: 95% CI, 1.25, 5.99) and non-seminoma TC diagnosed under 8 years of age(OR, 2.72; 95% CI, 1.05, 7.04). In contrast, offspring of CMV IgG-seropositive mothers had a decreased risk of TC diagnosed under 8 years of age (OR, 0.35; 95% CI, 0.14, 0.89). Our results suggest that EBV and CMV infections may be associated with TC.}},
  author       = {{Holl, Katsiaryna and Surcel, Helja-Marja and Koskela, Pentti and Dillner, Joakim and Hallmans, Goran and Wadell, Goran and Kaasila, Marjo and Olafsdottir, Gudridur H. and Ogmundsdottir, Helga M. and Pukkala, Eero and Stattin, Par and Lehtinen, Matti}},
  issn         = {{1600-0463}},
  keywords     = {{testicular; cytomegalovirus; maternal infection; Epstein-Barr virus; cancer; offspring}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{816--822}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{APMIS : acta pathologica, microbiologica, et immunologica Scandinavica}},
  title        = {{Maternal Epstein-Barr virus and cytomegalovirus infections and risk of testicular cancer in the offspring: a nested case-control study}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0463.2008.00983.x}},
  doi          = {{10.1111/j.1600-0463.2008.00983.x}},
  volume       = {{116}},
  year         = {{2008}},
}