Altered structural network organization in cognitively normal individuals with amyloid pathology
Voevodskaya, Olga ; Pereira, Joana B. ; Volpe, Giovanni ; Lindberg, Olof LU ; Stomrud, Erik LU
; van Westen, Danielle
LU
; Westman, Eric
and Hansson, Oskar
LU
(2018)
In Neurobiology of Aging
64.
p.15-24
- Abstract
Recent findings show that structural network topology is disrupted in Alzheimer's disease (AD), with changes occurring already at the prodromal disease stages. Amyloid accumulation, a hallmark of AD, begins several decades before symptom onset, and its effects on brain connectivity at the earliest disease stages are not fully known. We studied global and local network changes in a large cohort of cognitively healthy individuals (N = 299, Swedish BioFINDER study) with and without amyloid-β (Aβ) pathology (based on cerebrospinal fluid Aβ42/Aβ40 levels). Structural correlation matrices were constructed based on magnetic resonance imaging cortical thickness data. Despite the fact that no significant regional cortical atrophy was found in... (More)
Recent findings show that structural network topology is disrupted in Alzheimer's disease (AD), with changes occurring already at the prodromal disease stages. Amyloid accumulation, a hallmark of AD, begins several decades before symptom onset, and its effects on brain connectivity at the earliest disease stages are not fully known. We studied global and local network changes in a large cohort of cognitively healthy individuals (N = 299, Swedish BioFINDER study) with and without amyloid-β (Aβ) pathology (based on cerebrospinal fluid Aβ42/Aβ40 levels). Structural correlation matrices were constructed based on magnetic resonance imaging cortical thickness data. Despite the fact that no significant regional cortical atrophy was found in the Aβ-positive group, this group exhibited an altered global network organization, including decreased global efficiency and modularity. At the local level, Aβ-positive individuals displayed fewer and more disorganized modules as well as a loss of hubs. Our findings suggest that changes in network topology occur already at the presymptomatic (preclinical) stage of AD and may precede detectable cortical thinning.
(Less)
- author
- Voevodskaya, Olga
; Pereira, Joana B.
; Volpe, Giovanni
; Lindberg, Olof
LU
; Stomrud, Erik
LU
; van Westen, Danielle
LU
; Westman, Eric
and Hansson, Oskar
LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, Global efficiency, Graph theory, Hubs, Modularity, Structural covariance networks, β-Amyloid
- in
- Neurobiology of Aging
- volume
- 64
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85040051361
- pmid:29316528
- ISSN
- 0197-4580
- DOI
- 10.1016/j.neurobiolaging.2017.11.014
- language
- English
- LU publication?
- yes
- id
- 12d6c331-9c10-4653-8cf3-879968672e00
- date added to LUP
- 2018-01-23 13:46:41
- date last changed
- 2024-04-15 01:01:20
@article{12d6c331-9c10-4653-8cf3-879968672e00,
abstract = {{<p>Recent findings show that structural network topology is disrupted in Alzheimer's disease (AD), with changes occurring already at the prodromal disease stages. Amyloid accumulation, a hallmark of AD, begins several decades before symptom onset, and its effects on brain connectivity at the earliest disease stages are not fully known. We studied global and local network changes in a large cohort of cognitively healthy individuals (N = 299, Swedish BioFINDER study) with and without amyloid-β (Aβ) pathology (based on cerebrospinal fluid Aβ42/Aβ40 levels). Structural correlation matrices were constructed based on magnetic resonance imaging cortical thickness data. Despite the fact that no significant regional cortical atrophy was found in the Aβ-positive group, this group exhibited an altered global network organization, including decreased global efficiency and modularity. At the local level, Aβ-positive individuals displayed fewer and more disorganized modules as well as a loss of hubs. Our findings suggest that changes in network topology occur already at the presymptomatic (preclinical) stage of AD and may precede detectable cortical thinning.</p>}},
author = {{Voevodskaya, Olga and Pereira, Joana B. and Volpe, Giovanni and Lindberg, Olof and Stomrud, Erik and van Westen, Danielle and Westman, Eric and Hansson, Oskar}},
issn = {{0197-4580}},
keywords = {{Alzheimer's disease; Global efficiency; Graph theory; Hubs; Modularity; Structural covariance networks; β-Amyloid}},
language = {{eng}},
pages = {{15--24}},
publisher = {{Elsevier}},
series = {{Neurobiology of Aging}},
title = {{Altered structural network organization in cognitively normal individuals with amyloid pathology}},
url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2017.11.014}},
doi = {{10.1016/j.neurobiolaging.2017.11.014}},
volume = {{64}},
year = {{2018}},
}