A population-based cohort study on the use of hormone treatment and endometrial cancer in southern Sweden.
Epstein, Elisabeth LU ; Lindqvist, Pelle LU and Olsson, Håkan LU
(2009)
In International Journal of Cancer
125.
p.421-425
- Abstract
- Our aim was to determine the risk of endometrial cancer associated with long-term use of combined hormone therapy (HT) and low-potency estrogens. In this prospective population-based cohort, 40,000 women aged 25-64 years, without prior cancer or hysterectomy, were included. The women answered 2 questionnaires at a 10-year interval regarding HT use and personal details. Women were followed up for an average of 15.5 years through the National Cancer and Causes of Death Registry, representing 236,611 women years. Among the 17,822 postmenopausal women included, 166 cases of endometrial cancer were diagnosed. Only use of combined HT was related to a decreased risk of endometrial cancer (OR 0.3, 95% CI 0.1-0.8), the protective effect was found... (More)
- Our aim was to determine the risk of endometrial cancer associated with long-term use of combined hormone therapy (HT) and low-potency estrogens. In this prospective population-based cohort, 40,000 women aged 25-64 years, without prior cancer or hysterectomy, were included. The women answered 2 questionnaires at a 10-year interval regarding HT use and personal details. Women were followed up for an average of 15.5 years through the National Cancer and Causes of Death Registry, representing 236,611 women years. Among the 17,822 postmenopausal women included, 166 cases of endometrial cancer were diagnosed. Only use of combined HT was related to a decreased risk of endometrial cancer (OR 0.3, 95% CI 0.1-0.8), the protective effect was found after 2 years, and increased with extended duration of use. "Only use" of low-potency estrogens increased the risk of endometrial cancer almost to the same extent as use of high-potency estrogens (OR 2.0, 95% CI 1.1-3.6 vs. OR 2.5, 95% CI 1.3-4.8), the increased risk was confined to non-obese women in both groups. The risk was significantly increased for oral but not for local low-potency estrogen users (OR 2.1, 95% CI 1.1-3.6 vs. OR 1.5, 95% CI 0.4-6.2, respectively). In long-term estrogen users the risk was highest during the first 2 years, dropping slightly thereafter. Since low-potency estrogen use increases the risk of endometrial cancer almost as much as high-potency estrogen use, they should only be given if medically indicated. (c) 2009 UICC. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1367417
- author
- Epstein, Elisabeth
LU
; Lindqvist, Pelle
LU
and Olsson, Håkan
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Cancer
- volume
- 125
- pages
- 421 - 425
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000267231600022
- pmid:19326453
- scopus:67449095070
- pmid:19326453
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.24284
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Obstetrics and Gynaecology (Lund) (013018000), Oncology, MV (013035000), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- d2daef20-4a0a-4921-bcf0-7d6b4c6a228f (old id 1367417)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19326453?dopt=Abstract
- date added to LUP
- 2016-04-04 08:54:32
- date last changed
- 2025-04-04 14:06:25
@article{d2daef20-4a0a-4921-bcf0-7d6b4c6a228f,
abstract = {{Our aim was to determine the risk of endometrial cancer associated with long-term use of combined hormone therapy (HT) and low-potency estrogens. In this prospective population-based cohort, 40,000 women aged 25-64 years, without prior cancer or hysterectomy, were included. The women answered 2 questionnaires at a 10-year interval regarding HT use and personal details. Women were followed up for an average of 15.5 years through the National Cancer and Causes of Death Registry, representing 236,611 women years. Among the 17,822 postmenopausal women included, 166 cases of endometrial cancer were diagnosed. Only use of combined HT was related to a decreased risk of endometrial cancer (OR 0.3, 95% CI 0.1-0.8), the protective effect was found after 2 years, and increased with extended duration of use. "Only use" of low-potency estrogens increased the risk of endometrial cancer almost to the same extent as use of high-potency estrogens (OR 2.0, 95% CI 1.1-3.6 vs. OR 2.5, 95% CI 1.3-4.8), the increased risk was confined to non-obese women in both groups. The risk was significantly increased for oral but not for local low-potency estrogen users (OR 2.1, 95% CI 1.1-3.6 vs. OR 1.5, 95% CI 0.4-6.2, respectively). In long-term estrogen users the risk was highest during the first 2 years, dropping slightly thereafter. Since low-potency estrogen use increases the risk of endometrial cancer almost as much as high-potency estrogen use, they should only be given if medically indicated. (c) 2009 UICC.}},
author = {{Epstein, Elisabeth and Lindqvist, Pelle and Olsson, Håkan}},
issn = {{0020-7136}},
language = {{eng}},
pages = {{421--425}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{A population-based cohort study on the use of hormone treatment and endometrial cancer in southern Sweden.}},
url = {{http://dx.doi.org/10.1002/ijc.24284}},
doi = {{10.1002/ijc.24284}},
volume = {{125}},
year = {{2009}},
}