SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.
Egesten, Arne LU ; Olin, Anders LU ; Linge, Helena LU ; Yadav, Manisha LU ; Mörgelin, Matthias LU ; Karlsson, Anna and Collin, Mattias LU
(2009)
In PLoS ONE
4(3).
- Abstract
- BACKGROUND: CXC chemokines are induced by inflammatory stimuli in epithelial cells and some, like MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11, are antibacterial for Streptococcus pyogenes. METHODOLOGY/PRINCIPAL FINDINGS: SpeB from S. pyogenes degrades a wide range of chemokines (i.e. IP10/CXCL10, I-TAC/CXCL11, PF4/CXCL4, GROalpha/CXCL1, GRObeta/CXCL2, GROgamma/CXCL3, ENA78/CXCL5, GCP-2/CXCL6, NAP-2/CXCL7, SDF-1/CXCL12, BCA-1/CXCL13, BRAK/CXCL14, SRPSOX/CXCL16, MIP-3alpha/CCL20, Lymphotactin/XCL1, and Fractalkine/CX3CL1), has no activity on IL-8/CXCL8 and RANTES/CCL5, partly degrades SRPSOX/CXCL16 and MIP-3alpha/CCL20, and releases a 6 kDa CXCL9 fragment. CXCL10 and CXCL11 loose receptor activating and antibacterial activities, while the CXCL9... (More)
- BACKGROUND: CXC chemokines are induced by inflammatory stimuli in epithelial cells and some, like MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11, are antibacterial for Streptococcus pyogenes. METHODOLOGY/PRINCIPAL FINDINGS: SpeB from S. pyogenes degrades a wide range of chemokines (i.e. IP10/CXCL10, I-TAC/CXCL11, PF4/CXCL4, GROalpha/CXCL1, GRObeta/CXCL2, GROgamma/CXCL3, ENA78/CXCL5, GCP-2/CXCL6, NAP-2/CXCL7, SDF-1/CXCL12, BCA-1/CXCL13, BRAK/CXCL14, SRPSOX/CXCL16, MIP-3alpha/CCL20, Lymphotactin/XCL1, and Fractalkine/CX3CL1), has no activity on IL-8/CXCL8 and RANTES/CCL5, partly degrades SRPSOX/CXCL16 and MIP-3alpha/CCL20, and releases a 6 kDa CXCL9 fragment. CXCL10 and CXCL11 loose receptor activating and antibacterial activities, while the CXCL9 fragment does not activate the receptor CXCR3 but retains its antibacterial activity. CONCLUSIONS/SIGNIFICANCE: SpeB destroys most of the signaling and antibacterial properties of chemokines expressed by an inflamed epithelium. The exception is CXCL9 that preserves its antibacterial activity after hydrolysis, emphasizing its role as a major antimicrobial on inflamed epithelium. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1367917
- author
- Egesten, Arne
LU
; Olin, Anders
LU
; Linge, Helena
LU
; Yadav, Manisha
LU
; Mörgelin, Matthias
LU
; Karlsson, Anna
and Collin, Mattias
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 4
- issue
- 3
- article number
- e4769
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000265496000009
- pmid:19274094
- scopus:62849125047
- pmid:19274094
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0004769
- language
- English
- LU publication?
- yes
- id
- b5a7e057-0b83-48d9-aa21-a7a132aa413e (old id 1367917)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19274094?dopt=Abstract
- date added to LUP
- 2016-04-01 14:16:55
- date last changed
- 2022-04-14 08:58:50
@article{b5a7e057-0b83-48d9-aa21-a7a132aa413e,
abstract = {{BACKGROUND: CXC chemokines are induced by inflammatory stimuli in epithelial cells and some, like MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11, are antibacterial for Streptococcus pyogenes. METHODOLOGY/PRINCIPAL FINDINGS: SpeB from S. pyogenes degrades a wide range of chemokines (i.e. IP10/CXCL10, I-TAC/CXCL11, PF4/CXCL4, GROalpha/CXCL1, GRObeta/CXCL2, GROgamma/CXCL3, ENA78/CXCL5, GCP-2/CXCL6, NAP-2/CXCL7, SDF-1/CXCL12, BCA-1/CXCL13, BRAK/CXCL14, SRPSOX/CXCL16, MIP-3alpha/CCL20, Lymphotactin/XCL1, and Fractalkine/CX3CL1), has no activity on IL-8/CXCL8 and RANTES/CCL5, partly degrades SRPSOX/CXCL16 and MIP-3alpha/CCL20, and releases a 6 kDa CXCL9 fragment. CXCL10 and CXCL11 loose receptor activating and antibacterial activities, while the CXCL9 fragment does not activate the receptor CXCR3 but retains its antibacterial activity. CONCLUSIONS/SIGNIFICANCE: SpeB destroys most of the signaling and antibacterial properties of chemokines expressed by an inflamed epithelium. The exception is CXCL9 that preserves its antibacterial activity after hydrolysis, emphasizing its role as a major antimicrobial on inflamed epithelium.}},
author = {{Egesten, Arne and Olin, Anders and Linge, Helena and Yadav, Manisha and Mörgelin, Matthias and Karlsson, Anna and Collin, Mattias}},
issn = {{1932-6203}},
language = {{eng}},
number = {{3}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.}},
url = {{https://lup.lub.lu.se/search/files/3889402/1389068.pdf}},
doi = {{10.1371/journal.pone.0004769}},
volume = {{4}},
year = {{2009}},
}