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Non-alcoholic Steatohepatitis Induces a Decrease in the Levels of S-100b in the Rat Brain

Ushakova, G. A. ; Fomenko, O. Z. and Pierzynowski, Stefan LU (2008) In Neurophysiology 40(4). p.316-318
Abstract
Using an experimental model of non-alcoholic (alimentary-induced) steatohepatitis in rats, we found that this pathological condition created by consumption of a special diet for 16 weeks results in a drop in the brain mass (by 22%, on average) and also in decreases in the size and morphological modifications of astrocytes and the level of a calcium-binding protein, S-100b. The latter shifts were greater in the hindbrain, including the cerebellum (34.8%), than in the hemispheres, including the thalamus, hypothalamus, hippocampus, and cortex (18.0%).
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
encephalopathy, hepatic, non-alcoholic steatohepatitis, S-100b, astrocytes
in
Neurophysiology
volume
40
issue
4
pages
316 - 318
publisher
Springer
external identifiers
  • wos:000263425200012
  • scopus:60649114645
ISSN
0090-2977
DOI
10.1007/s11062-009-9051-x
language
English
LU publication?
yes
id
0c41f437-afd8-4b31-9bb4-491454c08393 (old id 1375221)
date added to LUP
2016-04-01 15:02:15
date last changed
2022-01-28 03:48:35
@article{0c41f437-afd8-4b31-9bb4-491454c08393,
  abstract     = {{Using an experimental model of non-alcoholic (alimentary-induced) steatohepatitis in rats, we found that this pathological condition created by consumption of a special diet for 16 weeks results in a drop in the brain mass (by 22%, on average) and also in decreases in the size and morphological modifications of astrocytes and the level of a calcium-binding protein, S-100b. The latter shifts were greater in the hindbrain, including the cerebellum (34.8%), than in the hemispheres, including the thalamus, hypothalamus, hippocampus, and cortex (18.0%).}},
  author       = {{Ushakova, G. A. and Fomenko, O. Z. and Pierzynowski, Stefan}},
  issn         = {{0090-2977}},
  keywords     = {{encephalopathy; hepatic; non-alcoholic steatohepatitis; S-100b; astrocytes}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{316--318}},
  publisher    = {{Springer}},
  series       = {{Neurophysiology}},
  title        = {{Non-alcoholic Steatohepatitis Induces a Decrease in the Levels of S-100b in the Rat Brain}},
  url          = {{http://dx.doi.org/10.1007/s11062-009-9051-x}},
  doi          = {{10.1007/s11062-009-9051-x}},
  volume       = {{40}},
  year         = {{2008}},
}