The 5alpha-Reductase Type II A49T and V89L High-Activity Allelic Variants are More Common in Men with Prostate Cancer Compared with the General Population.
(2005) In European Urology 48(Jul 20). p.679-685- Abstract
- Objectives: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5 alpha-reductase II (SRD5A2) gene. Materials and methods: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n = 89), benign prostate hyperplasia (n = 45) and healthy military conscripts (n = 223). Results: The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p = 0.026 and p = 0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN < 23 had a higher... (More)
- Objectives: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5 alpha-reductase II (SRD5A2) gene. Materials and methods: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n = 89), benign prostate hyperplasia (n = 45) and healthy military conscripts (n = 223). Results: The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p = 0.026 and p = 0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN < 23 had a higher risk of dying from the disease than their counterparts with longer repeats. Conclusions: Men with CaP were more often genetically predisposed to a higher enzymatic activity in the turn over from T to DHT compared to the general population. In our population, androgen receptor genotype affected CaP outcome. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/143185
- author
- Giwercman, Yvonne LU ; Abrahamsson, Per-Anders LU ; Giwercman, Aleksander LU ; Gadaleanu, Virgil and Ahlgren, Göran LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 5 alpha-reductase, prostate cancer, polymorphism, androgen receptor
- in
- European Urology
- volume
- 48
- issue
- Jul 20
- pages
- 679 - 685
- publisher
- Elsevier
- external identifiers
-
- pmid:16039774
- wos:000232257300020
- scopus:24644440563
- ISSN
- 1873-7560
- DOI
- 10.1016/j.eururo.2005.06.011
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Obstetrics and Gynaecology (013242700), Division of urological research (013243410), Molecular Reproductive Medicine (013241710), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Department of Translational Medicine (013017500)
- id
- 149d3dbb-a396-4794-898e-6280fde74a0c (old id 143185)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16039774&dopt=Abstract
- date added to LUP
- 2016-04-01 15:39:41
- date last changed
- 2022-02-12 17:00:50
@article{149d3dbb-a396-4794-898e-6280fde74a0c, abstract = {{Objectives: To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5 alpha-reductase II (SRD5A2) gene. Materials and methods: The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n = 89), benign prostate hyperplasia (n = 45) and healthy military conscripts (n = 223). Results: The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p = 0.026 and p = 0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN < 23 had a higher risk of dying from the disease than their counterparts with longer repeats. Conclusions: Men with CaP were more often genetically predisposed to a higher enzymatic activity in the turn over from T to DHT compared to the general population. In our population, androgen receptor genotype affected CaP outcome.}}, author = {{Giwercman, Yvonne and Abrahamsson, Per-Anders and Giwercman, Aleksander and Gadaleanu, Virgil and Ahlgren, Göran}}, issn = {{1873-7560}}, keywords = {{5 alpha-reductase; prostate cancer; polymorphism; androgen receptor}}, language = {{eng}}, number = {{Jul 20}}, pages = {{679--685}}, publisher = {{Elsevier}}, series = {{European Urology}}, title = {{The 5alpha-Reductase Type II A49T and V89L High-Activity Allelic Variants are More Common in Men with Prostate Cancer Compared with the General Population.}}, url = {{https://lup.lub.lu.se/search/files/4443473/624938.pdf}}, doi = {{10.1016/j.eururo.2005.06.011}}, volume = {{48}}, year = {{2005}}, }