Relationship Between Mild Primary Hyperparathyroidism and Left Ventricular Structure and Diastolic Performance
(2009) In The Endocrinologist 19(4). p.187-191- Abstract
- Aim: This study aims to investigate cardiac structure and function in patients with asymptomatic primary hyperparathyroidism (pHPT) and if there is any relation to severity regarding serum levels of calcium (Ca) and parathyroid hormone. Methods and Results: We consecutively included 50 patients (mean age 62.9 +/- 11 years, 45 women) with clinically diagnosed pHPT. We prospectively recruited 50 healthy control subjects, matched for age and sex. Standard transthoracic echocardiographic examination was performed using the 4 standard views and structural parameters as well as left ventricular (LV) systolic and diastolic function was determined. Mean LV ejection fraction and atrioventricular plane displacement were on average normal and did not... (More)
- Aim: This study aims to investigate cardiac structure and function in patients with asymptomatic primary hyperparathyroidism (pHPT) and if there is any relation to severity regarding serum levels of calcium (Ca) and parathyroid hormone. Methods and Results: We consecutively included 50 patients (mean age 62.9 +/- 11 years, 45 women) with clinically diagnosed pHPT. We prospectively recruited 50 healthy control subjects, matched for age and sex. Standard transthoracic echocardiographic examination was performed using the 4 standard views and structural parameters as well as left ventricular (LV) systolic and diastolic function was determined. Mean LV ejection fraction and atrioventricular plane displacement were on average normal and did not differ between patients and controls. However, pHPT patients had significantly greater LV mass (148 +/- 37 vs. 127 +/- 29 g, P = 0.002), LV end diastolic area (81 +/- 20 vs. 68 +/- 18 cm(2), p = 0.003), LV posterior wall diameter (8.9 +/- 1 vs. 8.1 +/- 1 min, P = 0.006), and LA size (21 +/- 3 vs. 19 +/- 2 mm, P < 0.001). A moderate to severe LV diastolic filling impairment was present in substantially more pHPT patients, compared with control subjects (36% vs. 4%, P < 0:001). Conclusion: Patients with asymptomatic pHPT showed LV structural changes and impaired LV diastolic function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1461712
- author
- Birgander, Mats ; Bondeson, Anne-Greth LU ; Bondeson, Lennart LU ; Willenheimer, Ronnie LU and Rydberg, Erik LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- prognosis, echocardiography, heart failure, primary hyperparathyroidism
- in
- The Endocrinologist
- volume
- 19
- issue
- 4
- pages
- 187 - 191
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000268054600012
- scopus:68849101817
- ISSN
- 1539-9192
- DOI
- 10.1097/TEN.0b013e3181abe7a3
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cardiology Research Group (013242120), Pathology (Malmö) (013031000), Emergency medicine/Medicine/Surgery (013240200)
- id
- e7958958-6394-4826-bb7f-bddb75361ebe (old id 1461712)
- date added to LUP
- 2016-04-01 12:03:25
- date last changed
- 2022-01-26 22:12:52
@article{e7958958-6394-4826-bb7f-bddb75361ebe, abstract = {{Aim: This study aims to investigate cardiac structure and function in patients with asymptomatic primary hyperparathyroidism (pHPT) and if there is any relation to severity regarding serum levels of calcium (Ca) and parathyroid hormone. Methods and Results: We consecutively included 50 patients (mean age 62.9 +/- 11 years, 45 women) with clinically diagnosed pHPT. We prospectively recruited 50 healthy control subjects, matched for age and sex. Standard transthoracic echocardiographic examination was performed using the 4 standard views and structural parameters as well as left ventricular (LV) systolic and diastolic function was determined. Mean LV ejection fraction and atrioventricular plane displacement were on average normal and did not differ between patients and controls. However, pHPT patients had significantly greater LV mass (148 +/- 37 vs. 127 +/- 29 g, P = 0.002), LV end diastolic area (81 +/- 20 vs. 68 +/- 18 cm(2), p = 0.003), LV posterior wall diameter (8.9 +/- 1 vs. 8.1 +/- 1 min, P = 0.006), and LA size (21 +/- 3 vs. 19 +/- 2 mm, P < 0.001). A moderate to severe LV diastolic filling impairment was present in substantially more pHPT patients, compared with control subjects (36% vs. 4%, P < 0:001). Conclusion: Patients with asymptomatic pHPT showed LV structural changes and impaired LV diastolic function.}}, author = {{Birgander, Mats and Bondeson, Anne-Greth and Bondeson, Lennart and Willenheimer, Ronnie and Rydberg, Erik}}, issn = {{1539-9192}}, keywords = {{prognosis; echocardiography; heart failure; primary hyperparathyroidism}}, language = {{eng}}, number = {{4}}, pages = {{187--191}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{The Endocrinologist}}, title = {{Relationship Between Mild Primary Hyperparathyroidism and Left Ventricular Structure and Diastolic Performance}}, url = {{http://dx.doi.org/10.1097/TEN.0b013e3181abe7a3}}, doi = {{10.1097/TEN.0b013e3181abe7a3}}, volume = {{19}}, year = {{2009}}, }