Noninvasive monitoring of brain temperature during mild hypothermia
(2009) In Magnetic Resonance Imaging 27(7). p.923-932- Abstract
- The main purpose of this study was to verify the feasibility of brain temperature mapping with high-spatial- and reduced-spectral-resolution magnetic resonance spectroscopic imaging (MRSI). A secondary goal was to determine the temperature coefficient of water chemical shift in the brain with and without internal spectral reference. The accuracy of the proposed MRSI method was verified using a water and vegetable oil phantom. Selective decrease of the brain temperature of pigs was induced by intranasal cooling. Temperature reductions between 2 degrees C and 4 degrees C were achieved within 20 min. The relative changes in temperature during the cooling process were monitored using MRSI. The reference temperature was measured with... (More)
- The main purpose of this study was to verify the feasibility of brain temperature mapping with high-spatial- and reduced-spectral-resolution magnetic resonance spectroscopic imaging (MRSI). A secondary goal was to determine the temperature coefficient of water chemical shift in the brain with and without internal spectral reference. The accuracy of the proposed MRSI method was verified using a water and vegetable oil phantom. Selective decrease of the brain temperature of pigs was induced by intranasal cooling. Temperature reductions between 2 degrees C and 4 degrees C were achieved within 20 min. The relative changes in temperature during the cooling process were monitored using MRSI. The reference temperature was measured with MR-compatible fiber-optic probes. Single-voxel H-1 MRS was used for measurement of absolute brain temperature at baseline and at the end of cooling. The temperature coefficient of the water chemical shift of brain tissue measured by MRSI without internal reference was -0.0192 +/- 0.0019 ppm/degrees C. The temperature coefficients of the water chemical shift relative to N-acetylaspartate, choline-containing compounds and creatine were -0.0096 +/- 0.0009, -0.0083 +/- 0.0007 and -0.0091 +/- 0.0011 ppm/degrees C, respectively. The results of this study indicate that MRSI with high spatial and reduced spectral resolutions is a reliable tool for monitoring long-term temperature changes in the brain. (C) 2009 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1475072
- author
- Weis, Jan ; Covaciu, Lucian ; Rubertsson, Sten ; Allers, Mats ; Lunderquist, Anders LU and Ahlstrom, Hakan
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Temperature mapping, Selective brain cooling, Hypothermia, Spectroscopy, Spectroscopic imaging
- in
- Magnetic Resonance Imaging
- volume
- 27
- issue
- 7
- pages
- 923 - 932
- publisher
- Elsevier
- external identifiers
-
- wos:000269613000005
- scopus:68349141237
- ISSN
- 1873-5894
- DOI
- 10.1016/j.mri.2009.01.011
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000)
- id
- eba26eec-ba2c-4d08-8143-18ff20a4e12d (old id 1475072)
- date added to LUP
- 2016-04-01 12:21:57
- date last changed
- 2022-02-03 21:12:33
@article{eba26eec-ba2c-4d08-8143-18ff20a4e12d,
abstract = {{The main purpose of this study was to verify the feasibility of brain temperature mapping with high-spatial- and reduced-spectral-resolution magnetic resonance spectroscopic imaging (MRSI). A secondary goal was to determine the temperature coefficient of water chemical shift in the brain with and without internal spectral reference. The accuracy of the proposed MRSI method was verified using a water and vegetable oil phantom. Selective decrease of the brain temperature of pigs was induced by intranasal cooling. Temperature reductions between 2 degrees C and 4 degrees C were achieved within 20 min. The relative changes in temperature during the cooling process were monitored using MRSI. The reference temperature was measured with MR-compatible fiber-optic probes. Single-voxel H-1 MRS was used for measurement of absolute brain temperature at baseline and at the end of cooling. The temperature coefficient of the water chemical shift of brain tissue measured by MRSI without internal reference was -0.0192 +/- 0.0019 ppm/degrees C. The temperature coefficients of the water chemical shift relative to N-acetylaspartate, choline-containing compounds and creatine were -0.0096 +/- 0.0009, -0.0083 +/- 0.0007 and -0.0091 +/- 0.0011 ppm/degrees C, respectively. The results of this study indicate that MRSI with high spatial and reduced spectral resolutions is a reliable tool for monitoring long-term temperature changes in the brain. (C) 2009 Elsevier Inc. All rights reserved.}},
author = {{Weis, Jan and Covaciu, Lucian and Rubertsson, Sten and Allers, Mats and Lunderquist, Anders and Ahlstrom, Hakan}},
issn = {{1873-5894}},
keywords = {{Temperature mapping; Selective brain cooling; Hypothermia; Spectroscopy; Spectroscopic imaging}},
language = {{eng}},
number = {{7}},
pages = {{923--932}},
publisher = {{Elsevier}},
series = {{Magnetic Resonance Imaging}},
title = {{Noninvasive monitoring of brain temperature during mild hypothermia}},
url = {{http://dx.doi.org/10.1016/j.mri.2009.01.011}},
doi = {{10.1016/j.mri.2009.01.011}},
volume = {{27}},
year = {{2009}},
}