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Impact of a Perioperative Smoking and Alcohol Cessation Intervention on Health-related Quality of Life in Patients Undergoing Radical Cystectomy : A Randomised Controlled Trial

Lauridsen, Susanne Vahr ; Tønnesen, Hanne LU ; Thind, Peter ; Rasmussen, Mette LU orcid ; Kallemose, Thomas and Thomsen, Thordis LU (2025) In European Urology Focus 11(6). p.940-950
Abstract

Background and objective: The impact of a smoking and alcohol cessation intervention on health-related quality of life (HRQoL) following radical cystectomy (RC) is unclear. This study aimed to evaluate the effect of a 6-wk perioperative smoking and/or alcohol cessation intervention on HRQoL. A secondary objective was to assess the difference in HRQoL between patients with more than two and those with fewer complications. Methods: From 2014 to 2018, 104 patients referred to RC who smoked daily or consumed at least three alcohol units per day were enrolled in a multicentre randomised clinical trial. Participants were assigned to a 6-wk intensive smoking and/or alcohol cessation programme or standard care. The smoking cessation programme... (More)

Background and objective: The impact of a smoking and alcohol cessation intervention on health-related quality of life (HRQoL) following radical cystectomy (RC) is unclear. This study aimed to evaluate the effect of a 6-wk perioperative smoking and/or alcohol cessation intervention on HRQoL. A secondary objective was to assess the difference in HRQoL between patients with more than two and those with fewer complications. Methods: From 2014 to 2018, 104 patients referred to RC who smoked daily or consumed at least three alcohol units per day were enrolled in a multicentre randomised clinical trial. Participants were assigned to a 6-wk intensive smoking and/or alcohol cessation programme or standard care. The smoking cessation programme had five meetings in 6 wk and was based on the principles of motivational interviewing, balanced decision-making, and the transtheoretical model of change. HRQoL was assessed at baseline, and 6 and 12 mo using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and BLM30 questionnaires. Linear regression models were used to analyse the association between intervention, complications, and HRQoL. Key findings and limitations: There were differences in baseline demographic and lifestyle factors between groups. At the end of intervention, 51% of the intervention group and 27% of the control group quit successfully; after 12 mo, 21% and 36%, respectively, were quitters. No significant differences in HRQoL were found between the intervention and control groups. However, patients with more than two complications had significantly lower HRQoL on the QLQ-C30 scale, while no difference was observed on the BLM30 scale. A study limitation is the nonparticipation rate of 53%. Conclusions and clinical implications: The cessation intervention did not impact HRQoL significantly in patients undergoing RC. However, patients with more than two complications experienced reduced HRQoL, highlighting the importance of identifying at-risk patients preoperatively.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alcohol cessation, Bladder cancer, Health-related quality of life, Radical cystectomy, Smoking cessation
in
European Urology Focus
volume
11
issue
6
pages
11 pages
publisher
Elsevier
external identifiers
  • pmid:40744855
  • scopus:105012122686
ISSN
2405-4569
DOI
10.1016/j.euf.2025.07.009
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Author(s)
id
14d56221-f634-4a11-a39d-eb9683a18f16
date added to LUP
2026-01-26 11:43:56
date last changed
2026-01-27 03:41:22
@article{14d56221-f634-4a11-a39d-eb9683a18f16,
  abstract     = {{<p>Background and objective: The impact of a smoking and alcohol cessation intervention on health-related quality of life (HRQoL) following radical cystectomy (RC) is unclear. This study aimed to evaluate the effect of a 6-wk perioperative smoking and/or alcohol cessation intervention on HRQoL. A secondary objective was to assess the difference in HRQoL between patients with more than two and those with fewer complications. Methods: From 2014 to 2018, 104 patients referred to RC who smoked daily or consumed at least three alcohol units per day were enrolled in a multicentre randomised clinical trial. Participants were assigned to a 6-wk intensive smoking and/or alcohol cessation programme or standard care. The smoking cessation programme had five meetings in 6 wk and was based on the principles of motivational interviewing, balanced decision-making, and the transtheoretical model of change. HRQoL was assessed at baseline, and 6 and 12 mo using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and BLM30 questionnaires. Linear regression models were used to analyse the association between intervention, complications, and HRQoL. Key findings and limitations: There were differences in baseline demographic and lifestyle factors between groups. At the end of intervention, 51% of the intervention group and 27% of the control group quit successfully; after 12 mo, 21% and 36%, respectively, were quitters. No significant differences in HRQoL were found between the intervention and control groups. However, patients with more than two complications had significantly lower HRQoL on the QLQ-C30 scale, while no difference was observed on the BLM30 scale. A study limitation is the nonparticipation rate of 53%. Conclusions and clinical implications: The cessation intervention did not impact HRQoL significantly in patients undergoing RC. However, patients with more than two complications experienced reduced HRQoL, highlighting the importance of identifying at-risk patients preoperatively.</p>}},
  author       = {{Lauridsen, Susanne Vahr and Tønnesen, Hanne and Thind, Peter and Rasmussen, Mette and Kallemose, Thomas and Thomsen, Thordis}},
  issn         = {{2405-4569}},
  keywords     = {{Alcohol cessation; Bladder cancer; Health-related quality of life; Radical cystectomy; Smoking cessation}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{940--950}},
  publisher    = {{Elsevier}},
  series       = {{European Urology Focus}},
  title        = {{Impact of a Perioperative Smoking and Alcohol Cessation Intervention on Health-related Quality of Life in Patients Undergoing Radical Cystectomy : A Randomised Controlled Trial}},
  url          = {{http://dx.doi.org/10.1016/j.euf.2025.07.009}},
  doi          = {{10.1016/j.euf.2025.07.009}},
  volume       = {{11}},
  year         = {{2025}},
}