Transthyretin as a potential CSF biomarker for Alzheimer's disease and dementia with Lewy bodies: effects of treatment with cholinesterase inhibitors.
(2010) In European Journal of Neurology 17. p.456-460- Abstract
- Background: Previous studies have indicated that transthyretin (TTR) levels in cerebrospinal fluid (CSF) are altered in depression and dementia. The present study aimed to investigate whether CSF TTR can be used to discriminate between patients with Alzheimer's disease (AD) and patients with dementia with Lewy bodies (DLB) with or without medication, as well as to reveal whether CSF TTR correlates with depression in dementia. Methods: CSF samples from 59 patients with AD, 13 patients with DLB and 13 healthy controls were collected, and biochemical analysis was performed. Subjects were assessed for the presence of depression. Results: No significant differences in CSF TTR were found between AD, DLB, and control subjects or between depressed... (More)
- Background: Previous studies have indicated that transthyretin (TTR) levels in cerebrospinal fluid (CSF) are altered in depression and dementia. The present study aimed to investigate whether CSF TTR can be used to discriminate between patients with Alzheimer's disease (AD) and patients with dementia with Lewy bodies (DLB) with or without medication, as well as to reveal whether CSF TTR correlates with depression in dementia. Methods: CSF samples from 59 patients with AD, 13 patients with DLB and 13 healthy controls were collected, and biochemical analysis was performed. Subjects were assessed for the presence of depression. Results: No significant differences in CSF TTR were found between AD, DLB, and control subjects or between depressed and non-depressed dementia patients. Interestingly, we found a significant reduction in CSF TTR (14%) in AD patients who were medicated with cholinesterase inhibitors compared to those AD patients who were not. Conclusions: Significant reductions in CSF TTR were found after cholinesterase inhibitor treatment in patients with AD compared to untreated individuals. CSF TTR was unaltered in patients with DLB and had no relationship to depression in the present cohort with dementias. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1511810
- author
- Schultz, Kristofer LU ; Nilsson, K ; Nielsen, J E ; Lindquist, S G ; Hjermind, L E ; Andersen, B B ; Wallin, A ; Nilsson, C and Petersén, Åsa LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Neurology
- volume
- 17
- pages
- 456 - 460
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000274907000023
- pmid:19922456
- scopus:77649165856
- pmid:19922456
- ISSN
- 1351-5101
- DOI
- 10.1111/j.1468-1331.2009.02841.x
- language
- English
- LU publication?
- yes
- id
- 5931b470-67ad-4fb4-9661-11ea9d8992ce (old id 1511810)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19922456?dopt=Abstract
- date added to LUP
- 2016-04-04 08:55:51
- date last changed
- 2022-01-29 07:50:24
@article{5931b470-67ad-4fb4-9661-11ea9d8992ce,
abstract = {{Background: Previous studies have indicated that transthyretin (TTR) levels in cerebrospinal fluid (CSF) are altered in depression and dementia. The present study aimed to investigate whether CSF TTR can be used to discriminate between patients with Alzheimer's disease (AD) and patients with dementia with Lewy bodies (DLB) with or without medication, as well as to reveal whether CSF TTR correlates with depression in dementia. Methods: CSF samples from 59 patients with AD, 13 patients with DLB and 13 healthy controls were collected, and biochemical analysis was performed. Subjects were assessed for the presence of depression. Results: No significant differences in CSF TTR were found between AD, DLB, and control subjects or between depressed and non-depressed dementia patients. Interestingly, we found a significant reduction in CSF TTR (14%) in AD patients who were medicated with cholinesterase inhibitors compared to those AD patients who were not. Conclusions: Significant reductions in CSF TTR were found after cholinesterase inhibitor treatment in patients with AD compared to untreated individuals. CSF TTR was unaltered in patients with DLB and had no relationship to depression in the present cohort with dementias.}},
author = {{Schultz, Kristofer and Nilsson, K and Nielsen, J E and Lindquist, S G and Hjermind, L E and Andersen, B B and Wallin, A and Nilsson, C and Petersén, Åsa}},
issn = {{1351-5101}},
language = {{eng}},
pages = {{456--460}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Neurology}},
title = {{Transthyretin as a potential CSF biomarker for Alzheimer's disease and dementia with Lewy bodies: effects of treatment with cholinesterase inhibitors.}},
url = {{http://dx.doi.org/10.1111/j.1468-1331.2009.02841.x}},
doi = {{10.1111/j.1468-1331.2009.02841.x}},
volume = {{17}},
year = {{2010}},
}