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Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis : results from SCAPIS

Bergström, Göran ; Rosengren, Annika ; Bacsovics Brolin, Elin ; Brandberg, John ; Cederlund, Kerstin ; Engström, Gunnar LU ; Engvall, Jan E ; Eriksson, Maria J ; Gonçalves, Isabel LU orcid and Hagström, Emil , et al. (2023) In Atherosclerosis 373. p.46-54
Abstract
Background and aims
Elevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.
Methods
We used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential... (More)
Background and aims
Elevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.
Methods
We used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).
Results
The probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p Conclusions
Similar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Weight, Weight gain, Midlife, Coronary artery calcium score, Sex
in
Atherosclerosis
volume
373
pages
23 pages
publisher
Elsevier
external identifiers
  • scopus:85148722883
  • pmid:36813601
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2023.01.024
language
English
LU publication?
yes
id
153c7635-453d-4ced-a7f4-2aee9e4ef9a5
date added to LUP
2023-02-07 09:45:30
date last changed
2024-02-18 00:52:50
@article{153c7635-453d-4ced-a7f4-2aee9e4ef9a5,
  abstract     = {{Background and aims<br/>Elevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.<br/>Methods<br/>We used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).<br/>Results<br/>The probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p Conclusions<br/>Similar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis.}},
  author       = {{Bergström, Göran and Rosengren, Annika and Bacsovics Brolin, Elin and Brandberg, John and Cederlund, Kerstin and Engström, Gunnar and Engvall, Jan E and Eriksson, Maria J and Gonçalves, Isabel and Hagström, Emil and James, Stefan K. and Jernberg, Tomas and Lilja, Mikael and Magnusson, Martin and Persson, Anders and Persson, Margaretha and Sandström, Anette and Schmidt, Caroline and Skoglund Larsson, Linn and Sundström, Johan and Swahn, Eva and Söderberg, Stefan and Torén, Kjell and Östgren, Carl Johan and Lampa, Erik and Lind, Lars}},
  issn         = {{1879-1484}},
  keywords     = {{Weight; Weight gain; Midlife; Coronary artery calcium score; Sex}},
  language     = {{eng}},
  month        = {{02}},
  pages        = {{46--54}},
  publisher    = {{Elsevier}},
  series       = {{Atherosclerosis}},
  title        = {{Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis : results from SCAPIS}},
  url          = {{http://dx.doi.org/10.1016/j.atherosclerosis.2023.01.024}},
  doi          = {{10.1016/j.atherosclerosis.2023.01.024}},
  volume       = {{373}},
  year         = {{2023}},
}