Vildagliptin: an inhibitor of dipeptidyl peptidase-4 with antidiabetic properties.
(2006) In Expert Opinion on Investigational Drugs 15(4). p.431-442- Abstract
- Vilclagliptin is a competitive and reversible inhibitor of dipeptidyl peptidase-4. Dipeptidyl peptidase-4 inhibitors act mainly by preventing the rapid degradation of glucagon-like peptide-1. In clinical trials, vildagliptin improves glycaemic control both as monotherapy and in combination with metformin for periods of :! 52 weeks in subjects with Type 2 diabetes. This is evident by reduced fasting and prandial glucose levels, and reduced glycosylated haemoglobin levels. Vilclagliptin acts by increasing active glucagon-like peptide-1, improving p-cell function and inhibiting glucagon secretion. Furthermore, vildagliptin has proven to be safe and tolerable, with a low occurrence of hypoglycaemia. Further studies are now required to evaluate... (More)
- Vilclagliptin is a competitive and reversible inhibitor of dipeptidyl peptidase-4. Dipeptidyl peptidase-4 inhibitors act mainly by preventing the rapid degradation of glucagon-like peptide-1. In clinical trials, vildagliptin improves glycaemic control both as monotherapy and in combination with metformin for periods of :! 52 weeks in subjects with Type 2 diabetes. This is evident by reduced fasting and prandial glucose levels, and reduced glycosylated haemoglobin levels. Vilclagliptin acts by increasing active glucagon-like peptide-1, improving p-cell function and inhibiting glucagon secretion. Furthermore, vildagliptin has proven to be safe and tolerable, with a low occurrence of hypoglycaemia. Further studies are now required to evaluate its long-term durability, effects, safety and tolerability in comparison with other antidiabetic agents and in different patient subgroups. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/154511
- author
- Ahrén, Bo LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- GLP-1, DPP-4, vildagliptin, Type 2 diabetes, glycaemic control
- in
- Expert Opinion on Investigational Drugs
- volume
- 15
- issue
- 4
- pages
- 431 - 442
- publisher
- Ashley Publications
- external identifiers
-
- wos:000236651300010
- pmid:16548792
- scopus:33645707285
- ISSN
- 1744-7658
- DOI
- 10.1517/13543784.15.4.431
- language
- English
- LU publication?
- yes
- id
- e422269d-3cfc-4949-a86e-f2e2e927046c (old id 154511)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16548792&dopt=Abstract
- date added to LUP
- 2016-04-01 11:40:54
- date last changed
- 2024-01-07 16:27:08
@article{e422269d-3cfc-4949-a86e-f2e2e927046c,
abstract = {{Vilclagliptin is a competitive and reversible inhibitor of dipeptidyl peptidase-4. Dipeptidyl peptidase-4 inhibitors act mainly by preventing the rapid degradation of glucagon-like peptide-1. In clinical trials, vildagliptin improves glycaemic control both as monotherapy and in combination with metformin for periods of :! 52 weeks in subjects with Type 2 diabetes. This is evident by reduced fasting and prandial glucose levels, and reduced glycosylated haemoglobin levels. Vilclagliptin acts by increasing active glucagon-like peptide-1, improving p-cell function and inhibiting glucagon secretion. Furthermore, vildagliptin has proven to be safe and tolerable, with a low occurrence of hypoglycaemia. Further studies are now required to evaluate its long-term durability, effects, safety and tolerability in comparison with other antidiabetic agents and in different patient subgroups.}},
author = {{Ahrén, Bo}},
issn = {{1744-7658}},
keywords = {{GLP-1; DPP-4; vildagliptin; Type 2 diabetes; glycaemic control}},
language = {{eng}},
number = {{4}},
pages = {{431--442}},
publisher = {{Ashley Publications}},
series = {{Expert Opinion on Investigational Drugs}},
title = {{Vildagliptin: an inhibitor of dipeptidyl peptidase-4 with antidiabetic properties.}},
url = {{http://dx.doi.org/10.1517/13543784.15.4.431}},
doi = {{10.1517/13543784.15.4.431}},
volume = {{15}},
year = {{2006}},
}