Serum calcium and breast cancer risk: results from a prospective cohort study of 7,847 women.
(2007) In Cancer Causes and Control 18. p.595-602- Abstract
- Experimental and epidemiological studies suggest that calcium-regulating hormones-parathyroid hormone (PTH) and vitamin D-may be associated with breast cancer risk. No prospective cohort study has investigated the association between pre-diagnostic calcium levels and subsequent risk of breast cancer. We have examined this in a cohort of 7,847 women where serum calcium levels and established risk factors for breast cancer had been assessed at baseline. During a mean follow-up of 17.8 years, 437 incident breast cancer cases were diagnosed. Incidence of breast cancer was calculated in different quartiles of serum calcium levels and a Cox's proportional hazards analysis was used to obtain corresponding relative risks (RR), with a 95%... (More)
- Experimental and epidemiological studies suggest that calcium-regulating hormones-parathyroid hormone (PTH) and vitamin D-may be associated with breast cancer risk. No prospective cohort study has investigated the association between pre-diagnostic calcium levels and subsequent risk of breast cancer. We have examined this in a cohort of 7,847 women where serum calcium levels and established risk factors for breast cancer had been assessed at baseline. During a mean follow-up of 17.8 years, 437 incident breast cancer cases were diagnosed. Incidence of breast cancer was calculated in different quartiles of serum calcium levels and a Cox's proportional hazards analysis was used to obtain corresponding relative risks (RR), with a 95% confidence interval (CI), adjusted for potential confounders. In premenopausal women, serum calcium levels were inversely associated with breast cancer risk in a dose-response manner. The adjusted RR (95% CI) of breast cancer was in the 2nd calcium quartile 0.91 (0.65-1.30), in the 3rd quartile 0.89 (0.60-1.31), and in the 4th quartile 0.56 (0.32-0.98), as compared to the 1st calcium quartile. In postmenopausal overweight women (BMI > 25), breast cancer risk was higher in calcium quartiles 2-4 as compared to the 1st quartile. Our findings may have implications for primary prevention of breast cancer and for the management of asymptomatic primary hyperparathyroidism. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/167780
- author
- Almquist, Martin LU ; Manjer, Jonas LU ; Bondeson, Lennart LU and Bondeson, Anne-Greth LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- breast cancer, obesity, vitamin-D, parathyroid hormone, calcium
- in
- Cancer Causes and Control
- volume
- 18
- pages
- 595 - 602
- publisher
- Springer
- external identifiers
-
- wos:000247210500002
- scopus:34249999393
- ISSN
- 1573-7225
- DOI
- 10.1007/s10552-007-9001-0
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Pathology (Malmö) (013031000), Surgery Research Unit (013242220)
- id
- f1fa8845-a0cb-4569-be31-32b7777f3cf3 (old id 167780)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17410477&dopt=Abstract
- date added to LUP
- 2016-04-01 12:13:08
- date last changed
- 2022-05-19 02:45:59
@article{f1fa8845-a0cb-4569-be31-32b7777f3cf3,
abstract = {{Experimental and epidemiological studies suggest that calcium-regulating hormones-parathyroid hormone (PTH) and vitamin D-may be associated with breast cancer risk. No prospective cohort study has investigated the association between pre-diagnostic calcium levels and subsequent risk of breast cancer. We have examined this in a cohort of 7,847 women where serum calcium levels and established risk factors for breast cancer had been assessed at baseline. During a mean follow-up of 17.8 years, 437 incident breast cancer cases were diagnosed. Incidence of breast cancer was calculated in different quartiles of serum calcium levels and a Cox's proportional hazards analysis was used to obtain corresponding relative risks (RR), with a 95% confidence interval (CI), adjusted for potential confounders. In premenopausal women, serum calcium levels were inversely associated with breast cancer risk in a dose-response manner. The adjusted RR (95% CI) of breast cancer was in the 2nd calcium quartile 0.91 (0.65-1.30), in the 3rd quartile 0.89 (0.60-1.31), and in the 4th quartile 0.56 (0.32-0.98), as compared to the 1st calcium quartile. In postmenopausal overweight women (BMI > 25), breast cancer risk was higher in calcium quartiles 2-4 as compared to the 1st quartile. Our findings may have implications for primary prevention of breast cancer and for the management of asymptomatic primary hyperparathyroidism.}},
author = {{Almquist, Martin and Manjer, Jonas and Bondeson, Lennart and Bondeson, Anne-Greth}},
issn = {{1573-7225}},
keywords = {{breast cancer; obesity; vitamin-D; parathyroid hormone; calcium}},
language = {{eng}},
pages = {{595--602}},
publisher = {{Springer}},
series = {{Cancer Causes and Control}},
title = {{Serum calcium and breast cancer risk: results from a prospective cohort study of 7,847 women.}},
url = {{https://lup.lub.lu.se/search/files/2831776/625930.pdf}},
doi = {{10.1007/s10552-007-9001-0}},
volume = {{18}},
year = {{2007}},
}