Pore formation and pore closure in Poly(D,L-lactide-co-glycolide) films.
Fredenberg, Susanne LU ; Wahlgren, Marie LU
; Reslow, Mats
and Axelsson, Anders
LU
(2011)
In Journal of Controlled Release
150.
p.142-149
- Abstract
- Pore formation and pore closure in poly(D,L-lactide-co-glycolide)-based drug delivery systems are two important processes as they control the release of the encapsulated drug. The phenomenon pore closure was investigated by studying the effects of the pH and the temperature of the release medium, and the properties of the polymer. Poly(D,L-lactide-co-glycolide) (PLG) films were subjected to a pore forming pre-treatment, and then pore closure was observed simultaneously with changes in glass transition temperature, wettability (contact angle), water absorption and mass remaining. To further understand the effect of pH, combined pore formation and pore closure were studied at different pH values. Pore closure was increased in a release... (More)
- Pore formation and pore closure in poly(D,L-lactide-co-glycolide)-based drug delivery systems are two important processes as they control the release of the encapsulated drug. The phenomenon pore closure was investigated by studying the effects of the pH and the temperature of the release medium, and the properties of the polymer. Poly(D,L-lactide-co-glycolide) (PLG) films were subjected to a pore forming pre-treatment, and then pore closure was observed simultaneously with changes in glass transition temperature, wettability (contact angle), water absorption and mass remaining. To further understand the effect of pH, combined pore formation and pore closure were studied at different pH values. Pore closure was increased in a release medium with low pH, with a low-molecular-weight PLG of relatively low degree of hydrophobicity, or at high temperature. Pore closure occurred by two different mechanisms, one based on polymer-polymer interactions and one on polymer-water interactions. The mobility of the PLG chains also played an important role. The surface of the PLG films were more porous at pH 5-6 than at lower or higher pH, as pore formation was relatively fast and pore closure were less pronounced in this pH range. The pH had a significant impact on the porous structure, which should be kept in mind when evaluating experimental results, as the pH may be significantly decreased in vitro, in vivo and in situ. The results also show that the initial porosity is very important when using a high-molecular-weight PLG. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1731726
- author
- Fredenberg, Susanne
LU
; Wahlgren, Marie
LU
; Reslow, Mats
and Axelsson, Anders
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Controlled Release
- volume
- 150
- pages
- 142 - 149
- publisher
- Elsevier
- external identifiers
-
- wos:000289701200003
- pmid:21094192
- scopus:79952992027
- pmid:21094192
- ISSN
- 1873-4995
- DOI
- 10.1016/j.jconrel.2010.11.020
- language
- English
- LU publication?
- yes
- id
- 2c858323-a53d-4676-85a4-16560ca64f3f (old id 1731726)
- date added to LUP
- 2016-04-01 10:11:35
- date last changed
- 2023-11-09 14:26:52
@article{2c858323-a53d-4676-85a4-16560ca64f3f,
abstract = {{Pore formation and pore closure in poly(D,L-lactide-co-glycolide)-based drug delivery systems are two important processes as they control the release of the encapsulated drug. The phenomenon pore closure was investigated by studying the effects of the pH and the temperature of the release medium, and the properties of the polymer. Poly(D,L-lactide-co-glycolide) (PLG) films were subjected to a pore forming pre-treatment, and then pore closure was observed simultaneously with changes in glass transition temperature, wettability (contact angle), water absorption and mass remaining. To further understand the effect of pH, combined pore formation and pore closure were studied at different pH values. Pore closure was increased in a release medium with low pH, with a low-molecular-weight PLG of relatively low degree of hydrophobicity, or at high temperature. Pore closure occurred by two different mechanisms, one based on polymer-polymer interactions and one on polymer-water interactions. The mobility of the PLG chains also played an important role. The surface of the PLG films were more porous at pH 5-6 than at lower or higher pH, as pore formation was relatively fast and pore closure were less pronounced in this pH range. The pH had a significant impact on the porous structure, which should be kept in mind when evaluating experimental results, as the pH may be significantly decreased in vitro, in vivo and in situ. The results also show that the initial porosity is very important when using a high-molecular-weight PLG.}},
author = {{Fredenberg, Susanne and Wahlgren, Marie and Reslow, Mats and Axelsson, Anders}},
issn = {{1873-4995}},
language = {{eng}},
pages = {{142--149}},
publisher = {{Elsevier}},
series = {{Journal of Controlled Release}},
title = {{Pore formation and pore closure in Poly(D,L-lactide-co-glycolide) films.}},
url = {{http://dx.doi.org/10.1016/j.jconrel.2010.11.020}},
doi = {{10.1016/j.jconrel.2010.11.020}},
volume = {{150}},
year = {{2011}},
}