Maternal and child outcome after in-vitro fertilization-a review of 25 years population based data from Sweden.
(2011) In Acta Obstetricia et Gynecologica Scandinavica 90(5). p.494-500- Abstract
- Objective. To summarize data on deliveries after IVF performed in Sweden up to 2006. Design. Cohort study of women and children, conceived after IVF with comparisons of deliveries after IVF before and after April 1, 2001. Setting. Study based on Swedish health registers. Population. Births registered in the Swedish Medical Birth Register with information on IVF from all IVF clinics in Sweden. Methods. Results from the second study period are summarized and outcomes between the two periods are compared. Long term follow-up is based on data from both periods. Main outcome measures. Maternal and perinatal outcomes, long term sequels. Results. Some maternal pregnancy complications decreased in rate, notably preeclampsia and PROM. The rate of... (More)
- Objective. To summarize data on deliveries after IVF performed in Sweden up to 2006. Design. Cohort study of women and children, conceived after IVF with comparisons of deliveries after IVF before and after April 1, 2001. Setting. Study based on Swedish health registers. Population. Births registered in the Swedish Medical Birth Register with information on IVF from all IVF clinics in Sweden. Methods. Results from the second study period are summarized and outcomes between the two periods are compared. Long term follow-up is based on data from both periods. Main outcome measures. Maternal and perinatal outcomes, long term sequels. Results. Some maternal pregnancy complications decreased in rate, notably preeclampsia and PROM. The rate of multiple births and preterm births decreased dramatically with a better neonatal outcome, including neonatal mortality. No difference in outcome existed between IVF and ICSI or between the use of fresh and cryopreserved embryos, but children born after blastocyst transfer had a slightly higher risk for preterm birth and congenital malformations than children born after cleavage stage transfer. An increased risk for cerebral palsy, possibly for attention deficit and hyperactivity disorder, for impaired visual acuity, and for childhood cancer was noted but these outcomes were rare also after IVF. An increased risk for asthma was demonstrated. No effect on maternal cancer risk was seen. Conclusions. A marked decrease in multiple births was the main reason for better pregnancy and neonatal outcome and may also have a beneficial effect on long-term results, notably cerebral palsy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1832028
- author
- Finnström, Orvar ; Källén, Bengt LU ; Lindam, Anna ; Nilsson, Emma ; Nygren, Karl-Gösta and Olausson, Petra Otterblad
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- multiple births, morbidity, long-term, neonatal outcome, In vitro fertilization, pregnancy
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 90
- issue
- 5
- pages
- 494 - 500
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000290360100013
- pmid:21306346
- scopus:79955060572
- pmid:21306346
- ISSN
- 1600-0412
- DOI
- 10.1111/j.1600-0412.2011.01088.x
- language
- English
- LU publication?
- yes
- id
- e1904598-4f6b-4c3c-bec7-e882572adf80 (old id 1832028)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21306346?dopt=Abstract
- date added to LUP
- 2016-04-01 13:36:32
- date last changed
- 2022-04-21 22:31:34
@article{e1904598-4f6b-4c3c-bec7-e882572adf80,
abstract = {{Objective. To summarize data on deliveries after IVF performed in Sweden up to 2006. Design. Cohort study of women and children, conceived after IVF with comparisons of deliveries after IVF before and after April 1, 2001. Setting. Study based on Swedish health registers. Population. Births registered in the Swedish Medical Birth Register with information on IVF from all IVF clinics in Sweden. Methods. Results from the second study period are summarized and outcomes between the two periods are compared. Long term follow-up is based on data from both periods. Main outcome measures. Maternal and perinatal outcomes, long term sequels. Results. Some maternal pregnancy complications decreased in rate, notably preeclampsia and PROM. The rate of multiple births and preterm births decreased dramatically with a better neonatal outcome, including neonatal mortality. No difference in outcome existed between IVF and ICSI or between the use of fresh and cryopreserved embryos, but children born after blastocyst transfer had a slightly higher risk for preterm birth and congenital malformations than children born after cleavage stage transfer. An increased risk for cerebral palsy, possibly for attention deficit and hyperactivity disorder, for impaired visual acuity, and for childhood cancer was noted but these outcomes were rare also after IVF. An increased risk for asthma was demonstrated. No effect on maternal cancer risk was seen. Conclusions. A marked decrease in multiple births was the main reason for better pregnancy and neonatal outcome and may also have a beneficial effect on long-term results, notably cerebral palsy.}},
author = {{Finnström, Orvar and Källén, Bengt and Lindam, Anna and Nilsson, Emma and Nygren, Karl-Gösta and Olausson, Petra Otterblad}},
issn = {{1600-0412}},
keywords = {{multiple births; morbidity; long-term; neonatal outcome; In vitro fertilization; pregnancy}},
language = {{eng}},
number = {{5}},
pages = {{494--500}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Obstetricia et Gynecologica Scandinavica}},
title = {{Maternal and child outcome after in-vitro fertilization-a review of 25 years population based data from Sweden.}},
url = {{http://dx.doi.org/10.1111/j.1600-0412.2011.01088.x}},
doi = {{10.1111/j.1600-0412.2011.01088.x}},
volume = {{90}},
year = {{2011}},
}