Risk of Birth Abnormalities in the Offspring of Men With a History of Cancer: A Cohort Study Using Danish and Swedish National Registries.
(2011) In Journal of the National Cancer Institute 103. p.398-406- Abstract
- Background The potential mutagenic effects of cancer therapies and the growing number of young male cancer survivors have given rise to concern about the health of their offspring. Methods We identified all singleton children born alive in Denmark between 1994 and 2004 and in Sweden between 1994 and 2005 (n = 1 777 765). Of the 8670 children with a paternal history of cancer, 8162 were conceived naturally and 508 were conceived using assisted reproductive technologies (ARTs) (in vitro fertilization or intracytoplasmatic sperm injection). Of the 1 769 0795 children without a paternal history of cancer, 25 926 were conceived using ARTs. Associations between paternal history of cancer and risk of adverse birth outcomes of children conceived... (More)
- Background The potential mutagenic effects of cancer therapies and the growing number of young male cancer survivors have given rise to concern about the health of their offspring. Methods We identified all singleton children born alive in Denmark between 1994 and 2004 and in Sweden between 1994 and 2005 (n = 1 777 765). Of the 8670 children with a paternal history of cancer, 8162 were conceived naturally and 508 were conceived using assisted reproductive technologies (ARTs) (in vitro fertilization or intracytoplasmatic sperm injection). Of the 1 769 0795 children without a paternal history of cancer, 25 926 were conceived using ARTs. Associations between paternal history of cancer and risk of adverse birth outcomes of children conceived naturally or by ARTs were investigated using log-linear binomial models, yielding risk ratios (RRs) with 95% confidence intervals (CIs). All statistical tests were two-sided. Results The offspring of male cancer survivors were more likely to have major congenital abnormalities than the offspring of fathers with no history of cancer (RR = 1.17, 95% CI = 1.05 to 1.31, P = .0043, 3.7% vs 3.2%). However, the mode of conception (natural conception or ARTs) did not modify the association between paternal history of cancer and risk of congenital abnormalities (natural conception, RR = 1.17, 95% CI = 1.04 to 1.31; ARTs, RR = 1.22, 95% CI = 0.80 to 1.87, P(interaction) = .84). Conclusion We observed a statistically significant but modest increase in the risk of major congenital abnormalities among offspring of males with a history of cancer, independent of the mode of conception. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1832131
- author
- Ståhl, Olof LU ; Boyd, Heather A ; Giwercman, Aleksander LU ; Lindholm, Morten ; Jensen, Allan ; Krüger Kjær, Susanne ; Anderson, Harald LU ; Cavallin-Ståhl, Eva LU and Rylander, Lars LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the National Cancer Institute
- volume
- 103
- pages
- 398 - 406
- publisher
- Oxford University Press
- external identifiers
-
- wos:000288020800009
- pmid:21303994
- scopus:79952336354
- ISSN
- 1460-2105
- DOI
- 10.1093/jnci/djq550
- language
- English
- LU publication?
- yes
- id
- baefa2cc-c3bb-470a-a797-cc617cbdba19 (old id 1832131)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21303994?dopt=Abstract
- date added to LUP
- 2016-04-04 09:11:24
- date last changed
- 2022-01-29 08:39:14
@article{baefa2cc-c3bb-470a-a797-cc617cbdba19, abstract = {{Background The potential mutagenic effects of cancer therapies and the growing number of young male cancer survivors have given rise to concern about the health of their offspring. Methods We identified all singleton children born alive in Denmark between 1994 and 2004 and in Sweden between 1994 and 2005 (n = 1 777 765). Of the 8670 children with a paternal history of cancer, 8162 were conceived naturally and 508 were conceived using assisted reproductive technologies (ARTs) (in vitro fertilization or intracytoplasmatic sperm injection). Of the 1 769 0795 children without a paternal history of cancer, 25 926 were conceived using ARTs. Associations between paternal history of cancer and risk of adverse birth outcomes of children conceived naturally or by ARTs were investigated using log-linear binomial models, yielding risk ratios (RRs) with 95% confidence intervals (CIs). All statistical tests were two-sided. Results The offspring of male cancer survivors were more likely to have major congenital abnormalities than the offspring of fathers with no history of cancer (RR = 1.17, 95% CI = 1.05 to 1.31, P = .0043, 3.7% vs 3.2%). However, the mode of conception (natural conception or ARTs) did not modify the association between paternal history of cancer and risk of congenital abnormalities (natural conception, RR = 1.17, 95% CI = 1.04 to 1.31; ARTs, RR = 1.22, 95% CI = 0.80 to 1.87, P(interaction) = .84). Conclusion We observed a statistically significant but modest increase in the risk of major congenital abnormalities among offspring of males with a history of cancer, independent of the mode of conception.}}, author = {{Ståhl, Olof and Boyd, Heather A and Giwercman, Aleksander and Lindholm, Morten and Jensen, Allan and Krüger Kjær, Susanne and Anderson, Harald and Cavallin-Ståhl, Eva and Rylander, Lars}}, issn = {{1460-2105}}, language = {{eng}}, pages = {{398--406}}, publisher = {{Oxford University Press}}, series = {{Journal of the National Cancer Institute}}, title = {{Risk of Birth Abnormalities in the Offspring of Men With a History of Cancer: A Cohort Study Using Danish and Swedish National Registries.}}, url = {{http://dx.doi.org/10.1093/jnci/djq550}}, doi = {{10.1093/jnci/djq550}}, volume = {{103}}, year = {{2011}}, }