Physiological functions and clinical implications of sphingolipids in the gut.
(2011) In Journal of Digestive Diseases 12(2). p.60-70- Abstract
- Studies of sphingolipids have become one of the most rapidly advancing fields in the last two decades. These highly diverse lipids have been known to have multiple physiological functions and clinical implications in several diseases, including tumorigenesis, inflammation, atherosclerosis and neural degenerative diseases. Unlike other organs, sphingolipids in the intestinal tract are present not only as lipid constituents in the cells but also as dietary compositions for digestion in the lumen. The present review focuses on the presence of sphingolipids and their catalytic enzymes in the gut; the metabolism and the signaling effects of the metabolites and their impacts on barrier functions, cholesterol absorption, inflammatory diseases and... (More)
- Studies of sphingolipids have become one of the most rapidly advancing fields in the last two decades. These highly diverse lipids have been known to have multiple physiological functions and clinical implications in several diseases, including tumorigenesis, inflammation, atherosclerosis and neural degenerative diseases. Unlike other organs, sphingolipids in the intestinal tract are present not only as lipid constituents in the cells but also as dietary compositions for digestion in the lumen. The present review focuses on the presence of sphingolipids and their catalytic enzymes in the gut; the metabolism and the signaling effects of the metabolites and their impacts on barrier functions, cholesterol absorption, inflammatory diseases and tumor development in the gut. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1883981
- author
- Duan, Rui-Dong LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Digestive Diseases
- volume
- 12
- issue
- 2
- pages
- 60 - 70
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000288458600002
- pmid:21401891
- scopus:79952684482
- pmid:21401891
- ISSN
- 1751-2972
- DOI
- 10.1111/j.1751-2980.2011.00481.x
- language
- English
- LU publication?
- yes
- id
- ad019874-f3e5-4d26-9df3-6e6f8dbad3a1 (old id 1883981)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21401891?dopt=Abstract
- date added to LUP
- 2016-04-04 08:49:15
- date last changed
- 2024-01-12 06:27:15
@article{ad019874-f3e5-4d26-9df3-6e6f8dbad3a1,
abstract = {{Studies of sphingolipids have become one of the most rapidly advancing fields in the last two decades. These highly diverse lipids have been known to have multiple physiological functions and clinical implications in several diseases, including tumorigenesis, inflammation, atherosclerosis and neural degenerative diseases. Unlike other organs, sphingolipids in the intestinal tract are present not only as lipid constituents in the cells but also as dietary compositions for digestion in the lumen. The present review focuses on the presence of sphingolipids and their catalytic enzymes in the gut; the metabolism and the signaling effects of the metabolites and their impacts on barrier functions, cholesterol absorption, inflammatory diseases and tumor development in the gut.}},
author = {{Duan, Rui-Dong}},
issn = {{1751-2972}},
language = {{eng}},
number = {{2}},
pages = {{60--70}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Digestive Diseases}},
title = {{Physiological functions and clinical implications of sphingolipids in the gut.}},
url = {{http://dx.doi.org/10.1111/j.1751-2980.2011.00481.x}},
doi = {{10.1111/j.1751-2980.2011.00481.x}},
volume = {{12}},
year = {{2011}},
}