Age and gender differences in the association between Nt-proBNP and glucometabolic disturbances.
Leosdottir, Margrét LU ; Willenheimer, Ronnie LU ; Hall, Christian ; Tjora, Solve ; Malm, Johan LU ; Melander, Olle LU
and Nilsson, Peter
LU
(2011)
In Scandinavian cardiovascular journal : SCJ
45.
p.294-300
- Abstract
- Abstract Objectives. Glucometabolic disturbances are associated with myocardial dysfunction. Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse. Design. We examined cross-sectional associations between Nt-proBNP and 1) fasting plasma glucose (FPG), and 2) categories of glucometabolic disturbances, in middle-aged and older subjects (1266 men, 526 women), applying multivariate linear regression analysis. Results. FPG was positively correlated with Nt-proBNP among middle-aged men (p = 0.04) and negatively albeit non-significantly (p = 0.1) among middle-aged women. Weaker non-significant correlations were seen among... (More)
- Abstract Objectives. Glucometabolic disturbances are associated with myocardial dysfunction. Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse. Design. We examined cross-sectional associations between Nt-proBNP and 1) fasting plasma glucose (FPG), and 2) categories of glucometabolic disturbances, in middle-aged and older subjects (1266 men, 526 women), applying multivariate linear regression analysis. Results. FPG was positively correlated with Nt-proBNP among middle-aged men (p = 0.04) and negatively albeit non-significantly (p = 0.1) among middle-aged women. Weaker non-significant correlations were seen among older subjects. Middle-aged men with new-onset and prevalent diabetes had higher Nt-proBNP than the reference group (FPG ≤5.0 mmol/L): 9.53 (p = 0.002) and 8.23 (p = 0.02) vs. 5.71 pmol/L. No differences in Nt-proBNP between categories of glucometabolic disturbance were observed among older men or women. Conclusions. The results indicate an age- and gender difference in the ability of Nt-proBNP to identify myocardial dysfunction in relation to glucometabolic disturbances. Therefore, Nt-proBNP should be used with caution as a general surrogate marker for myocardial dysfunction in this setting. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1972230
- author
- Leosdottir, Margrét
LU
; Willenheimer, Ronnie
LU
; Hall, Christian
; Tjora, Solve
; Malm, Johan
LU
; Melander, Olle
LU
and Nilsson, Peter
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian cardiovascular journal : SCJ
- volume
- 45
- pages
- 294 - 300
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000296431100007
- pmid:21604967
- scopus:80455131144
- ISSN
- 1651-2006
- DOI
- 10.3109/14017431.2011.581763
- language
- English
- LU publication?
- yes
- id
- e1c7fd15-a8a3-45d4-991c-4ace263e2bf1 (old id 1972230)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21604967?dopt=Abstract
- date added to LUP
- 2016-04-04 09:17:34
- date last changed
- 2024-01-12 11:33:47
@article{e1c7fd15-a8a3-45d4-991c-4ace263e2bf1,
abstract = {{Abstract Objectives. Glucometabolic disturbances are associated with myocardial dysfunction. Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse. Design. We examined cross-sectional associations between Nt-proBNP and 1) fasting plasma glucose (FPG), and 2) categories of glucometabolic disturbances, in middle-aged and older subjects (1266 men, 526 women), applying multivariate linear regression analysis. Results. FPG was positively correlated with Nt-proBNP among middle-aged men (p = 0.04) and negatively albeit non-significantly (p = 0.1) among middle-aged women. Weaker non-significant correlations were seen among older subjects. Middle-aged men with new-onset and prevalent diabetes had higher Nt-proBNP than the reference group (FPG ≤5.0 mmol/L): 9.53 (p = 0.002) and 8.23 (p = 0.02) vs. 5.71 pmol/L. No differences in Nt-proBNP between categories of glucometabolic disturbance were observed among older men or women. Conclusions. The results indicate an age- and gender difference in the ability of Nt-proBNP to identify myocardial dysfunction in relation to glucometabolic disturbances. Therefore, Nt-proBNP should be used with caution as a general surrogate marker for myocardial dysfunction in this setting.}},
author = {{Leosdottir, Margrét and Willenheimer, Ronnie and Hall, Christian and Tjora, Solve and Malm, Johan and Melander, Olle and Nilsson, Peter}},
issn = {{1651-2006}},
language = {{eng}},
pages = {{294--300}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian cardiovascular journal : SCJ}},
title = {{Age and gender differences in the association between Nt-proBNP and glucometabolic disturbances.}},
url = {{http://dx.doi.org/10.3109/14017431.2011.581763}},
doi = {{10.3109/14017431.2011.581763}},
volume = {{45}},
year = {{2011}},
}