Ubiquitin Carboxyl-Terminal Esterase L1 (UCHL1) S18Y Polymorphism In Patients With Cataracts
(2011) In Ophthalmic Genetics 32(2). p.75-79- Abstract
- Methods: aEuro,Patients with cataract (n == 493) and controls (n == 142) were analyzed for the UCHL1 p.S18Y polymorphism using dynamic allele-specific hybridization. Results: aEuro,Significant differences were observed in allele and genotype frequencies of the p.S18Y polymorphism between controls and cataract patients, where a positive UCHL1 allele A carrier status was associated with the cataract diagnosis (adjusted OR 1.7 [95% CI == 1.1--2.6] p == 0.02). No significant differences were seen in genotype distribution when stratifying for type of cataract. Nor did the mean age at cataract surgery differ between genotypes. Conclusion: aEuro,The current study does not support a protective role for the UCHL1 S18Y polymorphism in cataract... (More)
- Methods: aEuro,Patients with cataract (n == 493) and controls (n == 142) were analyzed for the UCHL1 p.S18Y polymorphism using dynamic allele-specific hybridization. Results: aEuro,Significant differences were observed in allele and genotype frequencies of the p.S18Y polymorphism between controls and cataract patients, where a positive UCHL1 allele A carrier status was associated with the cataract diagnosis (adjusted OR 1.7 [95% CI == 1.1--2.6] p == 0.02). No significant differences were seen in genotype distribution when stratifying for type of cataract. Nor did the mean age at cataract surgery differ between genotypes. Conclusion: aEuro,The current study does not support a protective role for the UCHL1 S18Y polymorphism in cataract development, but may instead suggest a disease-promoting effect. (Less)
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https://lup.lub.lu.se/record/1986697
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Ophthalmic Genetics
- volume
- 32
- issue
- 2
- pages
- 75 - 79
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000290488500002
- scopus:79955844186
- ISSN
- 1744-5094
- DOI
- 10.3109/13816810.2010.544360
- language
- English
- LU publication?
- yes
- id
- 86c17938-720b-4e8a-961f-01c2931ed142 (old id 1986697)
- date added to LUP
- 2016-04-01 13:30:23
- date last changed
- 2022-01-27 19:36:19
@article{86c17938-720b-4e8a-961f-01c2931ed142, abstract = {{Methods: aEuro,Patients with cataract (n == 493) and controls (n == 142) were analyzed for the UCHL1 p.S18Y polymorphism using dynamic allele-specific hybridization. Results: aEuro,Significant differences were observed in allele and genotype frequencies of the p.S18Y polymorphism between controls and cataract patients, where a positive UCHL1 allele A carrier status was associated with the cataract diagnosis (adjusted OR 1.7 [95% CI == 1.1--2.6] p == 0.02). No significant differences were seen in genotype distribution when stratifying for type of cataract. Nor did the mean age at cataract surgery differ between genotypes. Conclusion: aEuro,The current study does not support a protective role for the UCHL1 S18Y polymorphism in cataract development, but may instead suggest a disease-promoting effect.}}, author = {{Rudolph, Thiemo and Sjolander, Annica and Palmer, Mona Seibt and Minthon, Lennart and Wallin, Anders and Andreasen, Niels and Tasa, Gunnar and Juronen, Erkki and Blennow, Kaj and Zetterberg, Henrik and Zetterberg, Madeleine}}, issn = {{1744-5094}}, language = {{eng}}, number = {{2}}, pages = {{75--79}}, publisher = {{Taylor & Francis}}, series = {{Ophthalmic Genetics}}, title = {{Ubiquitin Carboxyl-Terminal Esterase L1 (UCHL1) S18Y Polymorphism In Patients With Cataracts}}, url = {{http://dx.doi.org/10.3109/13816810.2010.544360}}, doi = {{10.3109/13816810.2010.544360}}, volume = {{32}}, year = {{2011}}, }