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Acute cytokine treatment stimulates glucose uptake and glycolysis in human keratinocytes

Holt, Vance ; Morén, Björn LU orcid ; Fryklund, Claes LU ; Colbert, Robert A. and Stenkula, Karin G. LU (2023) In Cytokine 161.
Abstract

During inflammation, cellular glucose uptake and glycolysis are upregulated to meet an increased energy demand. For example, keratinocyte glycolysis is essential for progression of psoriasis. Therefore, understanding the regulation of glucose metabolism in keratinocytes is of importance. Here, we show that the pro-inflammatory cytokines IFNγ and TNF together rapidly induce glucose uptake, glycolysis, and glycolytic capacity in cultured keratinocytes. Furthermore, we found that acute IFNγ and TNF stimulation induces glucose transporter 4 (GLUT4) translocation to the plasma membrane and engages AMPK-dependent intracellular signaling. Together, these findings suggest acute cytokine-induced glucose metabolism in keratinocytes could... (More)

During inflammation, cellular glucose uptake and glycolysis are upregulated to meet an increased energy demand. For example, keratinocyte glycolysis is essential for progression of psoriasis. Therefore, understanding the regulation of glucose metabolism in keratinocytes is of importance. Here, we show that the pro-inflammatory cytokines IFNγ and TNF together rapidly induce glucose uptake, glycolysis, and glycolytic capacity in cultured keratinocytes. Furthermore, we found that acute IFNγ and TNF stimulation induces glucose transporter 4 (GLUT4) translocation to the plasma membrane and engages AMPK-dependent intracellular signaling. Together, these findings suggest acute cytokine-induced glucose metabolism in keratinocytes could contribute to inflammation in psoriatic disease, and that GLUT4 is involved in these processes.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glucose uptake, GLUT4, IFNγ, Keratinocytes, TNF
in
Cytokine
volume
161
article number
156057
publisher
Academic Press
external identifiers
  • scopus:85139302317
  • pmid:36208532
ISSN
1043-4666
DOI
10.1016/j.cyto.2022.156057
language
English
LU publication?
yes
id
19949d58-a608-4283-8c02-8f440a8640a7
date added to LUP
2022-12-27 12:11:09
date last changed
2025-07-12 13:03:28
@article{19949d58-a608-4283-8c02-8f440a8640a7,
  abstract     = {{<p>During inflammation, cellular glucose uptake and glycolysis are upregulated to meet an increased energy demand. For example, keratinocyte glycolysis is essential for progression of psoriasis. Therefore, understanding the regulation of glucose metabolism in keratinocytes is of importance. Here, we show that the pro-inflammatory cytokines IFNγ and TNF together rapidly induce glucose uptake, glycolysis, and glycolytic capacity in cultured keratinocytes. Furthermore, we found that acute IFNγ and TNF stimulation induces glucose transporter 4 (GLUT4) translocation to the plasma membrane and engages AMPK-dependent intracellular signaling. Together, these findings suggest acute cytokine-induced glucose metabolism in keratinocytes could contribute to inflammation in psoriatic disease, and that GLUT4 is involved in these processes.</p>}},
  author       = {{Holt, Vance and Morén, Björn and Fryklund, Claes and Colbert, Robert A. and Stenkula, Karin G.}},
  issn         = {{1043-4666}},
  keywords     = {{Glucose uptake; GLUT4; IFNγ; Keratinocytes; TNF}},
  language     = {{eng}},
  publisher    = {{Academic Press}},
  series       = {{Cytokine}},
  title        = {{Acute cytokine treatment stimulates glucose uptake and glycolysis in human keratinocytes}},
  url          = {{http://dx.doi.org/10.1016/j.cyto.2022.156057}},
  doi          = {{10.1016/j.cyto.2022.156057}},
  volume       = {{161}},
  year         = {{2023}},
}