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Sleep-Administered ketamine/psychedelics : A streamlined strategy to address two challenges in research on ketamine and psychedelics

Arjmand, Shokouh ; Lindström, Mats B. LU orcid ; Sellgren, Carl M. and Wegener, Gregers (2025) In European Psychiatry 68(1).
Abstract

The dissociative effects of ketamine and psychedelics might be associated with their rapid antidepressant properties, raising questions about whether these effects are necessary for their therapeutic action. Additionally, the distinct dissociative experiences often reported by patients in clinical trials may reveal whether they receive an active treatment or a placebo, potentially introducing bias into the results. In this viewpoint, we propose administering ketamine/psychedelics to patients during sleep, offering a novel approach to address and explore these challenges.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blinding, ketamine, mechanism of action, psychedelics, rapid-Acting antidepressants
in
European Psychiatry
volume
68
issue
1
article number
e29
publisher
Elsevier Masson SAS
external identifiers
  • scopus:85217469074
  • pmid:39905718
ISSN
0924-9338
DOI
10.1192/j.eurpsy.2025.14
language
English
LU publication?
yes
id
1cb1f22d-fdf1-4a66-8668-1ea2b093e413
date added to LUP
2025-04-09 09:56:02
date last changed
2025-07-30 18:32:44
@article{1cb1f22d-fdf1-4a66-8668-1ea2b093e413,
  abstract     = {{<p>The dissociative effects of ketamine and psychedelics might be associated with their rapid antidepressant properties, raising questions about whether these effects are necessary for their therapeutic action. Additionally, the distinct dissociative experiences often reported by patients in clinical trials may reveal whether they receive an active treatment or a placebo, potentially introducing bias into the results. In this viewpoint, we propose administering ketamine/psychedelics to patients during sleep, offering a novel approach to address and explore these challenges.</p>}},
  author       = {{Arjmand, Shokouh and Lindström, Mats B. and Sellgren, Carl M. and Wegener, Gregers}},
  issn         = {{0924-9338}},
  keywords     = {{blinding; ketamine; mechanism of action; psychedelics; rapid-Acting antidepressants}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{1}},
  publisher    = {{Elsevier Masson SAS}},
  series       = {{European Psychiatry}},
  title        = {{Sleep-Administered ketamine/psychedelics : A streamlined strategy to address two challenges in research on ketamine and psychedelics}},
  url          = {{http://dx.doi.org/10.1192/j.eurpsy.2025.14}},
  doi          = {{10.1192/j.eurpsy.2025.14}},
  volume       = {{68}},
  year         = {{2025}},
}