Spatially Guided and Single Cell Tools to Map the Microenvironment in Cutaneous T-Cell Lymphoma
(2023) In Cancers 15(8). p.1-15- Abstract
- Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress remains a clinical unmet need. While the exact molecular events underlying disease progression are poorly resolved, the tumor microenvironment (TME) has emerged as an important driver. In particular, the Th1-to-Th2 shift in the immune response is now commonly identified across advanced-stage CTCL patients. Herein, we summarize the role of the TME in... (More)
- Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress remains a clinical unmet need. While the exact molecular events underlying disease progression are poorly resolved, the tumor microenvironment (TME) has emerged as an important driver. In particular, the Th1-to-Th2 shift in the immune response is now commonly identified across advanced-stage CTCL patients. Herein, we summarize the role of the TME in CTCL evolution and the latest studies in deciphering inter- and intra-patient heterogeneity. We introduce spatially resolved omics as a promising technology to advance immune-oncology efforts in CTCL. We propose the combined implementation of spatially guided and single-cell omics technologies in paired skin and blood samples. Such an approach will mediate in-depth profiling of phenotypic and molecular changes in reactive immune subpopulations and malignant T cells preceding the Th1-to-Th2 shift and reveal mechanisms underlying disease progression from skin-limited to systemic disease that collectively will lead to the discovery of novel biomarkers to improve patient prognostication and the design of personalized treatment strategies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1f88e44d-a4b2-4b11-bfcb-45abdf4f9587
- author
- Kalliara, Eirini LU ; Belfrage, Emma LU ; Gullberg, Urban LU ; Drott, Kristina LU and Ek, Sara LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancers
- volume
- 15
- issue
- 8
- article number
- 2362
- pages
- 1 - 15
- publisher
- MDPI AG
- external identifiers
-
- scopus:85153962845
- pmid:37190290
- ISSN
- 2072-6694
- DOI
- 10.3390/cancers15082362
- language
- English
- LU publication?
- yes
- id
- 1f88e44d-a4b2-4b11-bfcb-45abdf4f9587
- alternative location
- https://www.mdpi.com/2072-6694/15/8/2362
- date added to LUP
- 2023-05-02 08:42:03
- date last changed
- 2023-08-02 03:00:03
@article{1f88e44d-a4b2-4b11-bfcb-45abdf4f9587, abstract = {{Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress remains a clinical unmet need. While the exact molecular events underlying disease progression are poorly resolved, the tumor microenvironment (TME) has emerged as an important driver. In particular, the Th1-to-Th2 shift in the immune response is now commonly identified across advanced-stage CTCL patients. Herein, we summarize the role of the TME in CTCL evolution and the latest studies in deciphering inter- and intra-patient heterogeneity. We introduce spatially resolved omics as a promising technology to advance immune-oncology efforts in CTCL. We propose the combined implementation of spatially guided and single-cell omics technologies in paired skin and blood samples. Such an approach will mediate in-depth profiling of phenotypic and molecular changes in reactive immune subpopulations and malignant T cells preceding the Th1-to-Th2 shift and reveal mechanisms underlying disease progression from skin-limited to systemic disease that collectively will lead to the discovery of novel biomarkers to improve patient prognostication and the design of personalized treatment strategies.}}, author = {{Kalliara, Eirini and Belfrage, Emma and Gullberg, Urban and Drott, Kristina and Ek, Sara}}, issn = {{2072-6694}}, language = {{eng}}, number = {{8}}, pages = {{1--15}}, publisher = {{MDPI AG}}, series = {{Cancers}}, title = {{Spatially Guided and Single Cell Tools to Map the Microenvironment in Cutaneous T-Cell Lymphoma}}, url = {{http://dx.doi.org/10.3390/cancers15082362}}, doi = {{10.3390/cancers15082362}}, volume = {{15}}, year = {{2023}}, }