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Spatially Guided and Single Cell Tools to Map the Microenvironment in Cutaneous T-Cell Lymphoma

Kalliara, Eirini LU ; Belfrage, Emma LU ; Gullberg, Urban LU ; Drott, Kristina LU and Ek, Sara LU (2023) In Cancers 15(8). p.1-15
Abstract
Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress remains a clinical unmet need. While the exact molecular events underlying disease progression are poorly resolved, the tumor microenvironment (TME) has emerged as an important driver. In particular, the Th1-to-Th2 shift in the immune response is now commonly identified across advanced-stage CTCL patients. Herein, we summarize the role of the TME in... (More)
Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress remains a clinical unmet need. While the exact molecular events underlying disease progression are poorly resolved, the tumor microenvironment (TME) has emerged as an important driver. In particular, the Th1-to-Th2 shift in the immune response is now commonly identified across advanced-stage CTCL patients. Herein, we summarize the role of the TME in CTCL evolution and the latest studies in deciphering inter- and intra-patient heterogeneity. We introduce spatially resolved omics as a promising technology to advance immune-oncology efforts in CTCL. We propose the combined implementation of spatially guided and single-cell omics technologies in paired skin and blood samples. Such an approach will mediate in-depth profiling of phenotypic and molecular changes in reactive immune subpopulations and malignant T cells preceding the Th1-to-Th2 shift and reveal mechanisms underlying disease progression from skin-limited to systemic disease that collectively will lead to the discovery of novel biomarkers to improve patient prognostication and the design of personalized treatment strategies. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancers
volume
15
issue
8
article number
2362
pages
1 - 15
publisher
MDPI AG
external identifiers
  • scopus:85153962845
  • pmid:37190290
ISSN
2072-6694
DOI
10.3390/cancers15082362
language
English
LU publication?
yes
id
1f88e44d-a4b2-4b11-bfcb-45abdf4f9587
alternative location
https://www.mdpi.com/2072-6694/15/8/2362
date added to LUP
2023-05-02 08:42:03
date last changed
2023-08-02 03:00:03
@article{1f88e44d-a4b2-4b11-bfcb-45abdf4f9587,
  abstract     = {{Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress remains a clinical unmet need. While the exact molecular events underlying disease progression are poorly resolved, the tumor microenvironment (TME) has emerged as an important driver. In particular, the Th1-to-Th2 shift in the immune response is now commonly identified across advanced-stage CTCL patients. Herein, we summarize the role of the TME in CTCL evolution and the latest studies in deciphering inter- and intra-patient heterogeneity. We introduce spatially resolved omics as a promising technology to advance immune-oncology efforts in CTCL. We propose the combined implementation of spatially guided and single-cell omics technologies in paired skin and blood samples. Such an approach will mediate in-depth profiling of phenotypic and molecular changes in reactive immune subpopulations and malignant T cells preceding the Th1-to-Th2 shift and reveal mechanisms underlying disease progression from skin-limited to systemic disease that collectively will lead to the discovery of novel biomarkers to improve patient prognostication and the design of personalized treatment strategies.}},
  author       = {{Kalliara, Eirini and Belfrage, Emma and Gullberg, Urban and Drott, Kristina and Ek, Sara}},
  issn         = {{2072-6694}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1--15}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Spatially Guided and Single Cell Tools to Map the Microenvironment in Cutaneous T-Cell Lymphoma}},
  url          = {{http://dx.doi.org/10.3390/cancers15082362}},
  doi          = {{10.3390/cancers15082362}},
  volume       = {{15}},
  year         = {{2023}},
}