Glucose-sensing mechanisms in pancreatic beta-cells
(2005) In Philosophical Transactions of the Royal Society B: Biological Sciences 360(1464). p.2211-2225- Abstract
- The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of... (More)
- The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of insulin secretion. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/210871
- author
- MacDonald, Patrick LU ; Joseph, JW and Rorsman, Patrik LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- potential, membrane, ion channels, metabolism, glucose, insulin secretion, exocytosis
- in
- Philosophical Transactions of the Royal Society B: Biological Sciences
- volume
- 360
- issue
- 1464
- pages
- 2211 - 2225
- publisher
- Royal Society Publishing
- external identifiers
-
- pmid:16321791
- wos:000233992100003
- scopus:33244466564
- ISSN
- 1471-2970
- DOI
- 10.1098/rstb.2005.1762
- language
- English
- LU publication?
- yes
- id
- 50c4202d-b2e4-429f-9836-eb0c54e86ed7 (old id 210871)
- date added to LUP
- 2016-04-01 16:48:39
- date last changed
- 2022-03-15 03:00:44
@article{50c4202d-b2e4-429f-9836-eb0c54e86ed7,
abstract = {{The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of insulin secretion.}},
author = {{MacDonald, Patrick and Joseph, JW and Rorsman, Patrik}},
issn = {{1471-2970}},
keywords = {{potential; membrane; ion channels; metabolism; glucose; insulin secretion; exocytosis}},
language = {{eng}},
number = {{1464}},
pages = {{2211--2225}},
publisher = {{Royal Society Publishing}},
series = {{Philosophical Transactions of the Royal Society B: Biological Sciences}},
title = {{Glucose-sensing mechanisms in pancreatic beta-cells}},
url = {{http://dx.doi.org/10.1098/rstb.2005.1762}},
doi = {{10.1098/rstb.2005.1762}},
volume = {{360}},
year = {{2005}},
}