Prevalence of diabetes and hospitalization due to poor glycemic control in people with bladder cancer or renal cell carcinoma in Sweden
Andersson, Emelie ; Brådvik, Gunnar ; Nilsson, Fredrik O.L. ; Arpegård, Johannes ; Strambi, Angela ; Kollberg, Petter LU and Carlsson, Katarina Steen LU
(2024)
In BMC Urology
24(1).
- Abstract
Background: Bladder cancer (BC) and Renal cell carcinoma (RCC) are the most common urogenital cancers among both sexes, with a yearly global incidence of around 500 000 each. Both BC and RCC have been linked to diabetes. Poor glycemic control (malglycemia) is a serious consequence of diabetes and a possible consequence of systemic treatments used in BC and RCC. The objective of this study was to investigate the prevalence of diabetes and use of hospital-based care for malglycemia in people with BC or RCC. Methods: This Swedish retrospective population-based register study used national health-data registers for longitudinal data on cancer incidence covering 15 years, use of hospital-based health care, and filled prescriptions of... (More)
Background: Bladder cancer (BC) and Renal cell carcinoma (RCC) are the most common urogenital cancers among both sexes, with a yearly global incidence of around 500 000 each. Both BC and RCC have been linked to diabetes. Poor glycemic control (malglycemia) is a serious consequence of diabetes and a possible consequence of systemic treatments used in BC and RCC. The objective of this study was to investigate the prevalence of diabetes and use of hospital-based care for malglycemia in people with BC or RCC. Methods: This Swedish retrospective population-based register study used national health-data registers for longitudinal data on cancer incidence covering 15 years, use of hospital-based health care, and filled prescriptions of outpatient medications. Study endpoints included co-prevalence of diabetes in individuals with BC/RCC, healthcare resource utilization due to malglycemia, use of systemic corticosteroids, and changes in diabetes management for people with concomitant type 2 diabetes. Results: We identified 36,620 and 15,581 individuals diagnosed with BC and RCC, respectively, between 2006 and 2019. The proportion of individuals registered with diabetes was 24% in BC and 23% in RCC. An association between BC/RCC and poor glycemic control was found, although the number of malglycemic events in hospital-based care were few (65/59 per 1000 individuals with diabetes and BC/RCC respectively with at least one event). An earlier switch to insulin-based diabetes management was observed in BC/RCC compared to matched individuals with type 2 diabetes but no cancer. The results also indicated an association between steroid treatment and poor glycemic control, and that systemic corticosteroids were more common among people with BC/RCC compared to diabetes controls. Conclusion: The high prevalence of diabetes and increased use of systemic corticosteroid treatment observed in this large national study highlights the need for specific clinical management, risk-assessment, and monitoring of individuals with BC/RCC and diabetes.
(Less)
- author
- Andersson, Emelie
; Brådvik, Gunnar
; Nilsson, Fredrik O.L.
; Arpegård, Johannes
; Strambi, Angela
; Kollberg, Petter
LU
and Carlsson, Katarina Steen
LU
- organization
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diabetes Mellitus Type 2, Genitourinary Cancer, Immunomodulating treatment, Nested Case–Control Study, Population Registers, Renal Cell Cancer, Urinary Bladder Neoplasms
- in
- BMC Urology
- volume
- 24
- issue
- 1
- article number
- 148
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85198850292
- pmid:39020360
- ISSN
- 1471-2490
- DOI
- 10.1186/s12894-024-01536-2
- language
- English
- LU publication?
- yes
- id
- 22356e13-6526-42b5-b16f-8e16825fb320
- date added to LUP
- 2024-08-29 15:00:51
- date last changed
- 2024-08-30 03:00:02
@article{22356e13-6526-42b5-b16f-8e16825fb320,
abstract = {{<p>Background: Bladder cancer (BC) and Renal cell carcinoma (RCC) are the most common urogenital cancers among both sexes, with a yearly global incidence of around 500 000 each. Both BC and RCC have been linked to diabetes. Poor glycemic control (malglycemia) is a serious consequence of diabetes and a possible consequence of systemic treatments used in BC and RCC. The objective of this study was to investigate the prevalence of diabetes and use of hospital-based care for malglycemia in people with BC or RCC. Methods: This Swedish retrospective population-based register study used national health-data registers for longitudinal data on cancer incidence covering 15 years, use of hospital-based health care, and filled prescriptions of outpatient medications. Study endpoints included co-prevalence of diabetes in individuals with BC/RCC, healthcare resource utilization due to malglycemia, use of systemic corticosteroids, and changes in diabetes management for people with concomitant type 2 diabetes. Results: We identified 36,620 and 15,581 individuals diagnosed with BC and RCC, respectively, between 2006 and 2019. The proportion of individuals registered with diabetes was 24% in BC and 23% in RCC. An association between BC/RCC and poor glycemic control was found, although the number of malglycemic events in hospital-based care were few (65/59 per 1000 individuals with diabetes and BC/RCC respectively with at least one event). An earlier switch to insulin-based diabetes management was observed in BC/RCC compared to matched individuals with type 2 diabetes but no cancer. The results also indicated an association between steroid treatment and poor glycemic control, and that systemic corticosteroids were more common among people with BC/RCC compared to diabetes controls. Conclusion: The high prevalence of diabetes and increased use of systemic corticosteroid treatment observed in this large national study highlights the need for specific clinical management, risk-assessment, and monitoring of individuals with BC/RCC and diabetes.</p>}},
author = {{Andersson, Emelie and Brådvik, Gunnar and Nilsson, Fredrik O.L. and Arpegård, Johannes and Strambi, Angela and Kollberg, Petter and Carlsson, Katarina Steen}},
issn = {{1471-2490}},
keywords = {{Diabetes Mellitus Type 2; Genitourinary Cancer; Immunomodulating treatment; Nested Case–Control Study; Population Registers; Renal Cell Cancer; Urinary Bladder Neoplasms}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Urology}},
title = {{Prevalence of diabetes and hospitalization due to poor glycemic control in people with bladder cancer or renal cell carcinoma in Sweden}},
url = {{http://dx.doi.org/10.1186/s12894-024-01536-2}},
doi = {{10.1186/s12894-024-01536-2}},
volume = {{24}},
year = {{2024}},
}