Measurements of the Optical-properties of Tissue In Conjunction With Photodynamic Therapy
(1995) In Applied Optics 34(21). p.4609-4619- Abstract
- A simple optical dosimeter was used to measure the light intensity in rat liver and muscle in vivo with fibers positioned at different depths to investigate whether the light penetration changed during photodynamic therapy (PDT). The results were then correlated with measurements of the three optical-interaction coefficients mu(s), mu(a), and g for wavelengths in the range 500-800 nm for PDT-treated and nontreated rat liver and muscle tissue in vitro. A distinct increase in the absorption coefficient was seen immediately after treatment, in agreement with the decreasing light intensity observed during the treatment, as measured with the optical dosimeter. The collimated transmittance was measured with a narrow-beam setup, and an optical... (More)
- A simple optical dosimeter was used to measure the light intensity in rat liver and muscle in vivo with fibers positioned at different depths to investigate whether the light penetration changed during photodynamic therapy (PDT). The results were then correlated with measurements of the three optical-interaction coefficients mu(s), mu(a), and g for wavelengths in the range 500-800 nm for PDT-treated and nontreated rat liver and muscle tissue in vitro. A distinct increase in the absorption coefficient was seen immediately after treatment, in agreement with the decreasing light intensity observed during the treatment, as measured with the optical dosimeter. The collimated transmittance was measured with a narrow-beam setup, and an optical integrating sphere was used to measure the diffuse reflectance and total transmittance of the samples. The corresponding optical properties were obtained by spline interpolation of Monte Carlo-simulated data. To ensure that the measured values were correct, we performed calibration measurements with suspensions of polystyrene microspheres and ink. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2259047
- author
- Nilsson, A. M. K ; Berg, R and Andersson-Engels, Stefan LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Applied Optics
- volume
- 34
- issue
- 21
- pages
- 4609 - 4619
- publisher
- Optical Society of America
- external identifiers
-
- scopus:0000948303
- ISSN
- 2155-3165
- DOI
- 10.1364/AO.34.004609
- language
- English
- LU publication?
- yes
- id
- 248fe26f-60e6-4273-9b6b-8a5b071d9f02 (old id 2259047)
- date added to LUP
- 2016-04-04 08:55:55
- date last changed
- 2021-02-07 06:06:42
@article{248fe26f-60e6-4273-9b6b-8a5b071d9f02,
abstract = {{A simple optical dosimeter was used to measure the light intensity in rat liver and muscle in vivo with fibers positioned at different depths to investigate whether the light penetration changed during photodynamic therapy (PDT). The results were then correlated with measurements of the three optical-interaction coefficients mu(s), mu(a), and g for wavelengths in the range 500-800 nm for PDT-treated and nontreated rat liver and muscle tissue in vitro. A distinct increase in the absorption coefficient was seen immediately after treatment, in agreement with the decreasing light intensity observed during the treatment, as measured with the optical dosimeter. The collimated transmittance was measured with a narrow-beam setup, and an optical integrating sphere was used to measure the diffuse reflectance and total transmittance of the samples. The corresponding optical properties were obtained by spline interpolation of Monte Carlo-simulated data. To ensure that the measured values were correct, we performed calibration measurements with suspensions of polystyrene microspheres and ink.}},
author = {{Nilsson, A. M. K and Berg, R and Andersson-Engels, Stefan}},
issn = {{2155-3165}},
language = {{eng}},
number = {{21}},
pages = {{4609--4619}},
publisher = {{Optical Society of America}},
series = {{Applied Optics}},
title = {{Measurements of the Optical-properties of Tissue In Conjunction With Photodynamic Therapy}},
url = {{https://lup.lub.lu.se/search/files/5213390/2297479.pdf}},
doi = {{10.1364/AO.34.004609}},
volume = {{34}},
year = {{1995}},
}