Selective IgA Deficiency in Autoimmune Diseases
(2011) In Molecular Medicine 17(11-12). p.1383-1396- Abstract
- Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D). celiac disease (CD), myasthenia gravis (MG) and rheumatoid arthritis (RA) on the basis of both our own recent large-scale screening results and literature data. Genetic factors are important for the development of both IgAD and various autoimmune disorders, including GD, SLE, T1D, CD, MG and RA, and a strong association with the major histocompatibility complex (MHC) region has been... (More)
- Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D). celiac disease (CD), myasthenia gravis (MG) and rheumatoid arthritis (RA) on the basis of both our own recent large-scale screening results and literature data. Genetic factors are important for the development of both IgAD and various autoimmune disorders, including GD, SLE, T1D, CD, MG and RA, and a strong association with the major histocompatibility complex (MHC) region has been reported. In addition, non-MHC genes, such as interferon-induced helicase 1 (IFH1) and c-type lectin domain family 16, member A (CLEC16A), are also associated with the development of IgAD and some of the above diseases. This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders. (C) 2011 The Feinstein Institute for Medical Research, www.feinsteininstitute.org Online address: hffp://www.molmed.org doi: 10.2119/molmed.2011.00195 (Less)
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- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Medicine
- volume
- 17
- issue
- 11-12
- pages
- 1383 - 1396
- publisher
- The Feinstein Institute for Medical Research
- external identifiers
-
- wos:000297958800029
- scopus:82855177895
- pmid:21826374
- ISSN
- 1528-3658
- DOI
- 10.2119/molmed.2011.00195
- language
- English
- LU publication?
- yes
- id
- 7f7a4b63-ff7b-4d81-955e-d8cafd556a5e (old id 2279255)
- date added to LUP
- 2016-04-01 14:52:53
- date last changed
- 2022-03-14 08:11:15
@article{7f7a4b63-ff7b-4d81-955e-d8cafd556a5e, abstract = {{Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D). celiac disease (CD), myasthenia gravis (MG) and rheumatoid arthritis (RA) on the basis of both our own recent large-scale screening results and literature data. Genetic factors are important for the development of both IgAD and various autoimmune disorders, including GD, SLE, T1D, CD, MG and RA, and a strong association with the major histocompatibility complex (MHC) region has been reported. In addition, non-MHC genes, such as interferon-induced helicase 1 (IFH1) and c-type lectin domain family 16, member A (CLEC16A), are also associated with the development of IgAD and some of the above diseases. This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders. (C) 2011 The Feinstein Institute for Medical Research, www.feinsteininstitute.org Online address: hffp://www.molmed.org doi: 10.2119/molmed.2011.00195}}, author = {{Wang, Ning and Shen, Nan and Vyse, Timothy J. and Anand, Vidya and Gunnarson, Iva and Sturfelt, Gunnar and Rantapaa-Dahlqvist, Solbritt and Elvin, Kerstin and Truedsson, Lennart and Andersson, Bengt A. and Dahle, Charlotte and Ortqvist, Eva and Gregersen, Peter K. and Behrens, Timothy W. and Hammarstrom, Lennart}}, issn = {{1528-3658}}, language = {{eng}}, number = {{11-12}}, pages = {{1383--1396}}, publisher = {{The Feinstein Institute for Medical Research}}, series = {{Molecular Medicine}}, title = {{Selective IgA Deficiency in Autoimmune Diseases}}, url = {{http://dx.doi.org/10.2119/molmed.2011.00195}}, doi = {{10.2119/molmed.2011.00195}}, volume = {{17}}, year = {{2011}}, }