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Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy

Ushakova, G. A. ; Fomenko, O. Z. and Pierzynowski, Stefan LU (2011) In Neurophysiology 43(3). p.205-208
Abstract
We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hepatic encephalopathy, S-100b, NCAM, behavior
in
Neurophysiology
volume
43
issue
3
pages
205 - 208
publisher
Springer
external identifiers
  • wos:000297624700008
  • scopus:83555173286
ISSN
0090-2977
DOI
10.1007/s11062-011-9206-4
language
English
LU publication?
yes
id
b31385fc-b6a9-427e-9038-a9f683589e31 (old id 2291613)
date added to LUP
2016-04-01 14:45:32
date last changed
2025-10-14 09:53:51
@article{b31385fc-b6a9-427e-9038-a9f683589e31,
  abstract     = {{We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.}},
  author       = {{Ushakova, G. A. and Fomenko, O. Z. and Pierzynowski, Stefan}},
  issn         = {{0090-2977}},
  keywords     = {{hepatic encephalopathy; S-100b; NCAM; behavior}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{205--208}},
  publisher    = {{Springer}},
  series       = {{Neurophysiology}},
  title        = {{Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy}},
  url          = {{http://dx.doi.org/10.1007/s11062-011-9206-4}},
  doi          = {{10.1007/s11062-011-9206-4}},
  volume       = {{43}},
  year         = {{2011}},
}