Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer.
(2012) In Molecular and Cellular Endocrinology 351(2). p.279-285- Abstract
- Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR... (More)
- Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR (rs7371084) were predictors of higher LH levels and higher androgen sensitivity index in healthy subjects. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2336414
- author
- Brokken, Leon LU ; Giwercman, Yvonne LU ; Rajpert De-Meyts, Ewa ; Eberhard, Jakob LU ; Ståhl, Olof LU ; Cohn-Cedermark, Gabriella ; Daugaard, Gedske ; Arver, Stefan and Giwercman, Aleksander LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular and Cellular Endocrinology
- volume
- 351
- issue
- 2
- pages
- 279 - 285
- publisher
- Elsevier
- external identifiers
-
- wos:000301906500015
- pmid:22245602
- scopus:84857138660
- pmid:22245602
- ISSN
- 1872-8057
- DOI
- 10.1016/j.mce.2011.12.018
- language
- English
- LU publication?
- yes
- id
- 94c7ca68-fd10-4e21-8d7a-55bbc2be3c43 (old id 2336414)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22245602?dopt=Abstract
- date added to LUP
- 2016-04-01 11:07:22
- date last changed
- 2022-01-26 05:33:23
@article{94c7ca68-fd10-4e21-8d7a-55bbc2be3c43,
abstract = {{Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR (rs7371084) were predictors of higher LH levels and higher androgen sensitivity index in healthy subjects. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis.}},
author = {{Brokken, Leon and Giwercman, Yvonne and Rajpert De-Meyts, Ewa and Eberhard, Jakob and Ståhl, Olof and Cohn-Cedermark, Gabriella and Daugaard, Gedske and Arver, Stefan and Giwercman, Aleksander}},
issn = {{1872-8057}},
language = {{eng}},
number = {{2}},
pages = {{279--285}},
publisher = {{Elsevier}},
series = {{Molecular and Cellular Endocrinology}},
title = {{Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer.}},
url = {{https://lup.lub.lu.se/search/files/2397824/2370038.pdf}},
doi = {{10.1016/j.mce.2011.12.018}},
volume = {{351}},
year = {{2012}},
}