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Clinical Research with Advanced Diffusion Encoding Methods in MRI

Reymbaut, A. LU ; Zheng, Y. ; Li, S. ; Sun, W. ; Xu, H. ; Daimiel Naranjo, I. ; Thakur, S. ; Pinker-Domenig, K. ; Rajan, S. and Vanugopal, V. K. , et al. (2020) In New Developments in NMR 2020-January(24). p.406-429
Abstract

This chapter offers a comprehensive summary of applications of advanced diffusion encoding methods in MRI within a narrowly defined area of in vivo human measurements with imaging read-out and voxel-by-voxel data analysis. The list of methods comprises tensor-valued encoding to investigate cell densities, shapes, and orientations in heterogeneous tissues, time/frequency-dependent encoding for estimating structural length scales, adjustable velocity-encoding to monitor flow in the microcapillary network, double encoding with varying mixing times to assess diffusional exchange between distinct tissue microenvironments and across cell membranes, and relaxation-diffusion correlation to resolve and separately characterize tissue... (More)

This chapter offers a comprehensive summary of applications of advanced diffusion encoding methods in MRI within a narrowly defined area of in vivo human measurements with imaging read-out and voxel-by-voxel data analysis. The list of methods comprises tensor-valued encoding to investigate cell densities, shapes, and orientations in heterogeneous tissues, time/frequency-dependent encoding for estimating structural length scales, adjustable velocity-encoding to monitor flow in the microcapillary network, double encoding with varying mixing times to assess diffusional exchange between distinct tissue microenvironments and across cell membranes, and relaxation-diffusion correlation to resolve and separately characterize tissue microenvironments in terms of their local chemical composition and microstructure. The shown examples include proof-of-concept measurements on healthy volunteers, pilot investigations of pathologies, and clinical research involving 10-100 subjects. Studied organs include brain, breast, prostate, liver, kidney, placenta, muscle, and peripheral nerve, with examples of pathologies from tumors, schizophrenia, multiple sclerosis, stroke, neurocysticercosis, pre-eclampsia, and chronic exertional compartment syndrome.

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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Advanced Diffusion Encoding Methods in MRI
series title
New Developments in NMR
editor
Topgaard, Daniel
volume
2020-January
issue
24
pages
24 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85095713734
ISSN
2044-2548
2044-253X
DOI
10.1039/9781788019910-00406
language
English
LU publication?
yes
id
239a144b-4efe-4418-a9dd-701effc97b0b
date added to LUP
2020-11-26 15:10:27
date last changed
2024-05-15 22:09:51
@inbook{239a144b-4efe-4418-a9dd-701effc97b0b,
  abstract     = {{<p>This chapter offers a comprehensive summary of applications of advanced diffusion encoding methods in MRI within a narrowly defined area of in vivo human measurements with imaging read-out and voxel-by-voxel data analysis. The list of methods comprises tensor-valued encoding to investigate cell densities, shapes, and orientations in heterogeneous tissues, time/frequency-dependent encoding for estimating structural length scales, adjustable velocity-encoding to monitor flow in the microcapillary network, double encoding with varying mixing times to assess diffusional exchange between distinct tissue microenvironments and across cell membranes, and relaxation-diffusion correlation to resolve and separately characterize tissue microenvironments in terms of their local chemical composition and microstructure. The shown examples include proof-of-concept measurements on healthy volunteers, pilot investigations of pathologies, and clinical research involving 10-100 subjects. Studied organs include brain, breast, prostate, liver, kidney, placenta, muscle, and peripheral nerve, with examples of pathologies from tumors, schizophrenia, multiple sclerosis, stroke, neurocysticercosis, pre-eclampsia, and chronic exertional compartment syndrome. </p>}},
  author       = {{Reymbaut, A. and Zheng, Y. and Li, S. and Sun, W. and Xu, H. and Daimiel Naranjo, I. and Thakur, S. and Pinker-Domenig, K. and Rajan, S. and Vanugopal, V. K. and Mahajan, V. and Mahajan, H. and Critchley, J. and Durighel, G. and Sughrue, M. and Bryskhe, K. and Topgaard, D.}},
  booktitle    = {{Advanced Diffusion Encoding Methods in MRI}},
  editor       = {{Topgaard, Daniel}},
  issn         = {{2044-2548}},
  language     = {{eng}},
  number       = {{24}},
  pages        = {{406--429}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{New Developments in NMR}},
  title        = {{Clinical Research with Advanced Diffusion Encoding Methods in MRI}},
  url          = {{http://dx.doi.org/10.1039/9781788019910-00406}},
  doi          = {{10.1039/9781788019910-00406}},
  volume       = {{2020-January}},
  year         = {{2020}},
}