Potential biomarkers for early detection of pancreatic ductal adenocarcinoma
(2020) In Clinical and Translational Oncology 22(12). p.2170-2174- Abstract
Pancreatic cancer has the highest mortality amongst all major organ cancers. Early detection is key to reduce deaths related to pancreatic cancer. However, early detection has been challenged by the lack of non-invasive biomarkers with enough sensitivity and specificity to allow for screening. The gold standard is still carbohydrate antigen (CA 19-9), against which all new biomarkers must be evaluated. In this paper, we describe recent progress in the development of new pancreatic cancer biomarkers, focusing on proteins, metabolites, and genetic and epigenetic biomarkers. Although several promising biomarkers have been identified, they are all derived from retrospective studies and additional prospective studies are needed to confirm... (More)
Pancreatic cancer has the highest mortality amongst all major organ cancers. Early detection is key to reduce deaths related to pancreatic cancer. However, early detection has been challenged by the lack of non-invasive biomarkers with enough sensitivity and specificity to allow for screening. The gold standard is still carbohydrate antigen (CA 19-9), against which all new biomarkers must be evaluated. In this paper, we describe recent progress in the development of new pancreatic cancer biomarkers, focusing on proteins, metabolites, and genetic and epigenetic biomarkers. Although several promising biomarkers have been identified, they are all derived from retrospective studies and additional prospective studies are needed to confirm their clinical validity.
(Less)
- author
- Kriz, D. LU ; Ansari, D. LU and Andersson, R. LU
- organization
- publishing date
- 2020-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biomarkers, Early detection, Pancreatic cancer, Sensitivity, Specificity
- in
- Clinical and Translational Oncology
- volume
- 22
- issue
- 12
- pages
- 5 pages
- publisher
- Springer
- external identifiers
-
- scopus:85085014619
- pmid:32447642
- ISSN
- 1699-048X
- DOI
- 10.1007/s12094-020-02372-0
- language
- English
- LU publication?
- yes
- id
- 243adec8-fed5-4ae8-ae3c-9ffd5adec52e
- date added to LUP
- 2020-06-25 14:48:26
- date last changed
- 2024-06-27 20:32:35
@article{243adec8-fed5-4ae8-ae3c-9ffd5adec52e, abstract = {{<p>Pancreatic cancer has the highest mortality amongst all major organ cancers. Early detection is key to reduce deaths related to pancreatic cancer. However, early detection has been challenged by the lack of non-invasive biomarkers with enough sensitivity and specificity to allow for screening. The gold standard is still carbohydrate antigen (CA 19-9), against which all new biomarkers must be evaluated. In this paper, we describe recent progress in the development of new pancreatic cancer biomarkers, focusing on proteins, metabolites, and genetic and epigenetic biomarkers. Although several promising biomarkers have been identified, they are all derived from retrospective studies and additional prospective studies are needed to confirm their clinical validity.</p>}}, author = {{Kriz, D. and Ansari, D. and Andersson, R.}}, issn = {{1699-048X}}, keywords = {{Biomarkers; Early detection; Pancreatic cancer; Sensitivity; Specificity}}, language = {{eng}}, number = {{12}}, pages = {{2170--2174}}, publisher = {{Springer}}, series = {{Clinical and Translational Oncology}}, title = {{Potential biomarkers for early detection of pancreatic ductal adenocarcinoma}}, url = {{http://dx.doi.org/10.1007/s12094-020-02372-0}}, doi = {{10.1007/s12094-020-02372-0}}, volume = {{22}}, year = {{2020}}, }