Stability of peptide-HLA-I complexes and tapasin folding facilitation - tools to define immunogenic peptides
Geironson Ulfsson, Linda LU ; Roder, Gustav and Paulsson, Kajsa M LU
(2012)
In FEBS Letters
586(9).
p.1336-1343
- Abstract
- Only a small fraction of the peptides generated inside the cell end up being presented by HLA-I on the cell surface. High stability of peptide-HLA-I complexes and a low HLA-I tapasin-facilitation have been proposed to predict immunogenicity. We here set out to investigate if these parameters correlated and defined immunogenic peptides. Both peptide-HLA-B*08:01 and peptide-HLA-A*02:01 complexes showed small differences in tapasin-facilitation and larger differences in stability. This suggests that the stability of immunogenic peptide-HLA-I complexes vary above an HLA-I allomorph dependent lower limit (e. g. > 2 h for HLA-A*02:01), immunogenicity predicted by tapasin-facilitation may be defined by an equally allomorph unique upper value... (More)
- Only a small fraction of the peptides generated inside the cell end up being presented by HLA-I on the cell surface. High stability of peptide-HLA-I complexes and a low HLA-I tapasin-facilitation have been proposed to predict immunogenicity. We here set out to investigate if these parameters correlated and defined immunogenic peptides. Both peptide-HLA-B*08:01 and peptide-HLA-A*02:01 complexes showed small differences in tapasin-facilitation and larger differences in stability. This suggests that the stability of immunogenic peptide-HLA-I complexes vary above an HLA-I allomorph dependent lower limit (e. g. > 2 h for HLA-A*02:01), immunogenicity predicted by tapasin-facilitation may be defined by an equally allomorph unique upper value (e. g. tapasin-facilitation <1.5 for HLA-A*02:01), and variation above the stability-threshold does not directly reflect a variation in tapasin-facilitation. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2545441
- author
- Geironson Ulfsson, Linda
LU
; Roder, Gustav
and Paulsson, Kajsa M
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Tapasin, MHC-I, Peptide, Stability, Vaccine
- in
- FEBS Letters
- volume
- 586
- issue
- 9
- pages
- 1336 - 1343
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000303434200014
- pmid:22616994
- scopus:84860343019
- pmid:22616994
- ISSN
- 1873-3468
- DOI
- 10.1016/j.febslet.2012.03.045
- language
- English
- LU publication?
- yes
- id
- b5209b6f-1909-4cd6-b5f5-023b7758cc23 (old id 2545441)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22616994?dopt=Abstract
- date added to LUP
- 2016-04-01 14:29:14
- date last changed
- 2022-03-06 19:29:34
@article{b5209b6f-1909-4cd6-b5f5-023b7758cc23,
abstract = {{Only a small fraction of the peptides generated inside the cell end up being presented by HLA-I on the cell surface. High stability of peptide-HLA-I complexes and a low HLA-I tapasin-facilitation have been proposed to predict immunogenicity. We here set out to investigate if these parameters correlated and defined immunogenic peptides. Both peptide-HLA-B*08:01 and peptide-HLA-A*02:01 complexes showed small differences in tapasin-facilitation and larger differences in stability. This suggests that the stability of immunogenic peptide-HLA-I complexes vary above an HLA-I allomorph dependent lower limit (e. g. > 2 h for HLA-A*02:01), immunogenicity predicted by tapasin-facilitation may be defined by an equally allomorph unique upper value (e. g. tapasin-facilitation <1.5 for HLA-A*02:01), and variation above the stability-threshold does not directly reflect a variation in tapasin-facilitation. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.}},
author = {{Geironson Ulfsson, Linda and Roder, Gustav and Paulsson, Kajsa M}},
issn = {{1873-3468}},
keywords = {{Tapasin; MHC-I; Peptide; Stability; Vaccine}},
language = {{eng}},
number = {{9}},
pages = {{1336--1343}},
publisher = {{Wiley-Blackwell}},
series = {{FEBS Letters}},
title = {{Stability of peptide-HLA-I complexes and tapasin folding facilitation - tools to define immunogenic peptides}},
url = {{http://dx.doi.org/10.1016/j.febslet.2012.03.045}},
doi = {{10.1016/j.febslet.2012.03.045}},
volume = {{586}},
year = {{2012}},
}