Epithelial–mesenchymal transition, a spectrum of states : Role in lung development, homeostasis, and disease
(2018) In Developmental Dynamics 247(3). p.346-358- Abstract
Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and... (More)
Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. Developmental Dynamics 247:346–358, 2018.
(Less)
- author
- Jolly, Mohit Kumar ; Ward, Chris ; Eapen, Mathew Suji ; Myers, Stephen ; Hallgren, Oskar LU ; Levine, Herbert and Sohal, Sukhwinder Singh
- organization
- publishing date
- 2018-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chronic pulmonary obstructive disease (COPD), epithelial–mesenchymal transition (EMT), hybrid epithelial/mesenchymal, idiopathic pulmonary fibrosis (IPF), lung cancer
- in
- Developmental Dynamics
- volume
- 247
- issue
- 3
- pages
- 346 - 358
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85028985989
- pmid:28646553
- ISSN
- 1058-8388
- DOI
- 10.1002/dvdy.24541
- language
- English
- LU publication?
- yes
- id
- 27544c38-ff51-4b63-b42b-91f8a3047a3a
- date added to LUP
- 2019-05-24 09:25:23
- date last changed
- 2024-06-26 18:19:38
@article{27544c38-ff51-4b63-b42b-91f8a3047a3a, abstract = {{<p>Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. Developmental Dynamics 247:346–358, 2018.</p>}}, author = {{Jolly, Mohit Kumar and Ward, Chris and Eapen, Mathew Suji and Myers, Stephen and Hallgren, Oskar and Levine, Herbert and Sohal, Sukhwinder Singh}}, issn = {{1058-8388}}, keywords = {{chronic pulmonary obstructive disease (COPD); epithelial–mesenchymal transition (EMT); hybrid epithelial/mesenchymal; idiopathic pulmonary fibrosis (IPF); lung cancer}}, language = {{eng}}, month = {{03}}, number = {{3}}, pages = {{346--358}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Developmental Dynamics}}, title = {{Epithelial–mesenchymal transition, a spectrum of states : Role in lung development, homeostasis, and disease}}, url = {{http://dx.doi.org/10.1002/dvdy.24541}}, doi = {{10.1002/dvdy.24541}}, volume = {{247}}, year = {{2018}}, }