Association between preterm birth and intrauterine growth retardation and child asthma.
(2013) In European Respiratory Journal 41(3). p.671-676- Abstract
- An association between preterm birth and an increased risk for childhood asthma has been demonstrated but the importance of intrauterine growth retardation on asthma risk is unclear.Using data from Swedish health registers, infant characteristics and childhood asthma were studied. Analyses were made using Mantel-Haenszel methodology with adjustment for year of birth, maternal age, parity, smoking in early pregnancy, and maternal body mass index. Preterm birth, birth weight and birth weight for gestational week were analysed and childhood asthma was evaluated from prescriptions of anti-asthmatic drugs. Neonatal respiratory problems and treatment for them were studied as mediating factors.Both short gestational duration and intrauterine... (More)
- An association between preterm birth and an increased risk for childhood asthma has been demonstrated but the importance of intrauterine growth retardation on asthma risk is unclear.Using data from Swedish health registers, infant characteristics and childhood asthma were studied. Analyses were made using Mantel-Haenszel methodology with adjustment for year of birth, maternal age, parity, smoking in early pregnancy, and maternal body mass index. Preterm birth, birth weight and birth weight for gestational week were analysed and childhood asthma was evaluated from prescriptions of anti-asthmatic drugs. Neonatal respiratory problems and treatment for them were studied as mediating factors.Both short gestational duration and intrauterine growth retardation appeared as risk factors and seemed to act separately. The largest effect was seen from short gestational duration. Use of mechanical ventilation in the newborn period and bronchopulmonary dysplasia were strong risk factors. A moderately increased risk was also seen in infants born large for gestational age.We conclude that preterm birth is a stronger risk factor for childhood asthma than intrauterine growth disturbances, but the latter also affects the risk, also in term infants. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2859360
- author
- Källén, Bengt LU ; Finnström, O ; Nygren, Kg and Otterblad Olausson, P
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Respiratory Journal
- volume
- 41
- issue
- 3
- pages
- 671 - 676
- publisher
- European Respiratory Society
- external identifiers
-
- wos:000316158900027
- pmid:22700840
- scopus:84872648703
- pmid:22700840
- ISSN
- 1399-3003
- DOI
- 10.1183/09031936.00041912
- language
- English
- LU publication?
- yes
- id
- a50fdd29-ddee-44f1-b76b-2fbbd3f64222 (old id 2859360)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22700840?dopt=Abstract
- date added to LUP
- 2016-04-01 11:04:19
- date last changed
- 2022-04-20 08:45:37
@article{a50fdd29-ddee-44f1-b76b-2fbbd3f64222,
abstract = {{An association between preterm birth and an increased risk for childhood asthma has been demonstrated but the importance of intrauterine growth retardation on asthma risk is unclear.Using data from Swedish health registers, infant characteristics and childhood asthma were studied. Analyses were made using Mantel-Haenszel methodology with adjustment for year of birth, maternal age, parity, smoking in early pregnancy, and maternal body mass index. Preterm birth, birth weight and birth weight for gestational week were analysed and childhood asthma was evaluated from prescriptions of anti-asthmatic drugs. Neonatal respiratory problems and treatment for them were studied as mediating factors.Both short gestational duration and intrauterine growth retardation appeared as risk factors and seemed to act separately. The largest effect was seen from short gestational duration. Use of mechanical ventilation in the newborn period and bronchopulmonary dysplasia were strong risk factors. A moderately increased risk was also seen in infants born large for gestational age.We conclude that preterm birth is a stronger risk factor for childhood asthma than intrauterine growth disturbances, but the latter also affects the risk, also in term infants.}},
author = {{Källén, Bengt and Finnström, O and Nygren, Kg and Otterblad Olausson, P}},
issn = {{1399-3003}},
language = {{eng}},
number = {{3}},
pages = {{671--676}},
publisher = {{European Respiratory Society}},
series = {{European Respiratory Journal}},
title = {{Association between preterm birth and intrauterine growth retardation and child asthma.}},
url = {{http://dx.doi.org/10.1183/09031936.00041912}},
doi = {{10.1183/09031936.00041912}},
volume = {{41}},
year = {{2013}},
}