Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis
(2004) In Tissue Antigens 63(3). p.237-247- Abstract
- In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian MS patients and 386 Norwegian controls. All samples were, in addition, genotyped for the HLA-DR DQ haplotype, and the Norwegian case-control samples were also typed for HLA-A and -B loci. In the Norwegian sporadic MS patients association was seen with HLA-A, HLA-B, and with the D6S265 marker, located 100 kb centromeric to HLA-A. Associations with HLA-A and D6S265 loci were also suggested when restricting the analysis to HLA-DR15... (More)
- In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian MS patients and 386 Norwegian controls. All samples were, in addition, genotyped for the HLA-DR DQ haplotype, and the Norwegian case-control samples were also typed for HLA-A and -B loci. In the Norwegian sporadic MS patients association was seen with HLA-A, HLA-B, and with the D6S265 marker, located 100 kb centromeric to HLA-A. Associations with HLA-A and D6S265 loci were also suggested when restricting the analysis to HLA-DR15 haplotypes. In the sib-pair data a similar trend was seen with marker D6S265. Higher genotypic relative risk (GRR) was found for individuals who carry both HLA-DR15 and -A3 (GRR = 15), compared to those who carry only HLA-DR15 (GRR = 7), only HLA-A3 (GRR = 3) or none of these alleles (GRR = 1). The highest risk was conferred by a combination of HLA-DR15 and -A3 (odds ratio (OR) = 5.2). These results suggest that HLA-A or a gene in linkage disequilibrium with it may contribute to the HLA class II-associated genetic susceptibility to MS. (Less)
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https://lup.lub.lu.se/record/286876
- author
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- sclerosis, multiple, HLA-DR15, HLA-B7, HLA-A3, D6S265, genetic susceptibility
- in
- Tissue Antigens
- volume
- 63
- issue
- 3
- pages
- 237 - 247
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000188992000006
- pmid:14989713
- scopus:10744231677
- pmid:14989713
- ISSN
- 0001-2815
- DOI
- 10.1111/j.0001-2815.2004.00173.x
- language
- English
- LU publication?
- yes
- id
- 6426c0a7-9a89-4d71-b88c-4e9bf9bde907 (old id 286876)
- date added to LUP
- 2016-04-01 16:07:36
- date last changed
- 2022-03-14 22:19:48
@article{6426c0a7-9a89-4d71-b88c-4e9bf9bde907, abstract = {{In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian MS patients and 386 Norwegian controls. All samples were, in addition, genotyped for the HLA-DR DQ haplotype, and the Norwegian case-control samples were also typed for HLA-A and -B loci. In the Norwegian sporadic MS patients association was seen with HLA-A, HLA-B, and with the D6S265 marker, located 100 kb centromeric to HLA-A. Associations with HLA-A and D6S265 loci were also suggested when restricting the analysis to HLA-DR15 haplotypes. In the sib-pair data a similar trend was seen with marker D6S265. Higher genotypic relative risk (GRR) was found for individuals who carry both HLA-DR15 and -A3 (GRR = 15), compared to those who carry only HLA-DR15 (GRR = 7), only HLA-A3 (GRR = 3) or none of these alleles (GRR = 1). The highest risk was conferred by a combination of HLA-DR15 and -A3 (odds ratio (OR) = 5.2). These results suggest that HLA-A or a gene in linkage disequilibrium with it may contribute to the HLA class II-associated genetic susceptibility to MS.}}, author = {{Harbo, HF and Lie, BA and Sawcer, S and Celius, EG and Dai, KZ and Oturai, A and Hillert, J and Lorentzen, AR and Laaksonen, M and Myhr, KM and Ryder, LP and Fredrikson, S and Nyland, H and Sorensen, PS and Sandberg Wollheim, Magnhild and Andersen, O and Svejgaard, A and Edland, A and Mellgren, SI and Compston, A and Vartdal, F and Spurkland, A}}, issn = {{0001-2815}}, keywords = {{sclerosis; multiple; HLA-DR15; HLA-B7; HLA-A3; D6S265; genetic susceptibility}}, language = {{eng}}, number = {{3}}, pages = {{237--247}}, publisher = {{Wiley-Blackwell}}, series = {{Tissue Antigens}}, title = {{Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis}}, url = {{http://dx.doi.org/10.1111/j.0001-2815.2004.00173.x}}, doi = {{10.1111/j.0001-2815.2004.00173.x}}, volume = {{63}}, year = {{2004}}, }