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Bone Mineral Density in Relation to Chronic Kidney Disease after Heart Transplantation : A Retrospective Single-center Study at Skåne University Hospital in Lund 1988-2016

Löfdahl, Eveline LU ; Haggård, Carl LU and Rådegran, Göran LU (2020) In Transplantation direct 6(3).
Abstract

Background. Our aim was to investigate the bone mineral density (BMD) evolution and incidence of osteoporosis in relation to chronic kidney disease (CKD) up to 10 years after heart transplantation (HT). Methods. A retrospective analysis was performed on 159 HT patients at Skåne University Hospital in Lund 1988-2016. Results. The median follow-up time was 6.1 years (interquartile range = 7.5 y). HT patients with CKD stage <3 or normal kidney function before HT exhibited a greater mean BMD loss in the lumbar spine, compared to patients with CKD stage ≥3 before HT, at the first (-6.6% versus -2.5%, P = 0.029), second (-3.7% versus 2.1%, P = 0.018), and third (-2.0% versus 4.1%, P = 0.047) postoperative years, respectively. All included... (More)

Background. Our aim was to investigate the bone mineral density (BMD) evolution and incidence of osteoporosis in relation to chronic kidney disease (CKD) up to 10 years after heart transplantation (HT). Methods. A retrospective analysis was performed on 159 HT patients at Skåne University Hospital in Lund 1988-2016. Results. The median follow-up time was 6.1 years (interquartile range = 7.5 y). HT patients with CKD stage <3 or normal kidney function before HT exhibited a greater mean BMD loss in the lumbar spine, compared to patients with CKD stage ≥3 before HT, at the first (-6.6% versus -2.5%, P = 0.029), second (-3.7% versus 2.1%, P = 0.018), and third (-2.0% versus 4.1%, P = 0.047) postoperative years, respectively. All included HT patients exhibited a BMD loss in the femoral neck at the first postoperative year (-8.8% [-10.3 to -7.3] in patients with CKD stage <3 or normal kidney function and -9.3% [-13.2 to -5.5] in patients with CKD stage ≥3 before HT), which was not fully reversed up to 10 years after HT. In adjusted models, CKD stage <3 before HT did not predict osteopenia and osteoporosis in the lumbar spine or femoral neck. Conclusions. CKD before HT did not predict BMD loss or osteoporosis development after HT. The study is, however, limited by a lack of data on fractures, and further studies on the relationship between CKD and postoperative bone strength are encouraged.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Transplantation direct
volume
6
issue
3
article number
e537
publisher
Wolters Kluwer
external identifiers
  • scopus:85083889786
  • pmid:32195328
ISSN
2373-8731
DOI
10.1097/TXD.0000000000000981
language
English
LU publication?
yes
id
293eb5cc-d994-47e2-8bd0-bb2c852b9a7f
date added to LUP
2020-05-28 09:15:21
date last changed
2024-04-03 08:26:05
@article{293eb5cc-d994-47e2-8bd0-bb2c852b9a7f,
  abstract     = {{<p>Background. Our aim was to investigate the bone mineral density (BMD) evolution and incidence of osteoporosis in relation to chronic kidney disease (CKD) up to 10 years after heart transplantation (HT). Methods. A retrospective analysis was performed on 159 HT patients at Skåne University Hospital in Lund 1988-2016. Results. The median follow-up time was 6.1 years (interquartile range = 7.5 y). HT patients with CKD stage &lt;3 or normal kidney function before HT exhibited a greater mean BMD loss in the lumbar spine, compared to patients with CKD stage ≥3 before HT, at the first (-6.6% versus -2.5%, P = 0.029), second (-3.7% versus 2.1%, P = 0.018), and third (-2.0% versus 4.1%, P = 0.047) postoperative years, respectively. All included HT patients exhibited a BMD loss in the femoral neck at the first postoperative year (-8.8% [-10.3 to -7.3] in patients with CKD stage &lt;3 or normal kidney function and -9.3% [-13.2 to -5.5] in patients with CKD stage ≥3 before HT), which was not fully reversed up to 10 years after HT. In adjusted models, CKD stage &lt;3 before HT did not predict osteopenia and osteoporosis in the lumbar spine or femoral neck. Conclusions. CKD before HT did not predict BMD loss or osteoporosis development after HT. The study is, however, limited by a lack of data on fractures, and further studies on the relationship between CKD and postoperative bone strength are encouraged.</p>}},
  author       = {{Löfdahl, Eveline and Haggård, Carl and Rådegran, Göran}},
  issn         = {{2373-8731}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{Wolters Kluwer}},
  series       = {{Transplantation direct}},
  title        = {{Bone Mineral Density in Relation to Chronic Kidney Disease after Heart Transplantation : A Retrospective Single-center Study at Skåne University Hospital in Lund 1988-2016}},
  url          = {{http://dx.doi.org/10.1097/TXD.0000000000000981}},
  doi          = {{10.1097/TXD.0000000000000981}},
  volume       = {{6}},
  year         = {{2020}},
}