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Breast cancer and its genetic heterogeneity at single cell level: A concise perspective of cellular architecture and taxonomy

Sharma, Riya ; Parihar, Neha ; Gopi, Keerti ; Yadav, Vikas LU orcid ; Sharma, Pooja ; Garg, Vivek Kumar ; Okpala, Charles Odilichukwu R. ; Buttar, Harpal Singh ; Takur, Sheetal and Goel, Neelam , et al. (2025) p.89-112
Abstract
Dealing with the heterogeneity of breast tumors and treating breast cancer patients pose a great challenge. The heterogeneity within and between tumors indicates that each case of breast cancer may have a good prognosis and could benefit from tailored therapies. Breast cancer is a condition that undergoes changes as the tumor progresses and metastasizes, which presents further challenges for implementing therapy decisions. To supplement existing information, we reflect on this contribution of breast cancer and its genetic heterogeneity at the single-cell level, providing a concise perspective of cellular architecture and taxonomy. Indeed, to determine the treatment strategy for recurrent breast cancer, it is important to evaluate biopsies... (More)
Dealing with the heterogeneity of breast tumors and treating breast cancer patients pose a great challenge. The heterogeneity within and between tumors indicates that each case of breast cancer may have a good prognosis and could benefit from tailored therapies. Breast cancer is a condition that undergoes changes as the tumor progresses and metastasizes, which presents further challenges for implementing therapy decisions. To supplement existing information, we reflect on this contribution of breast cancer and its genetic heterogeneity at the single-cell level, providing a concise perspective of cellular architecture and taxonomy. Indeed, to determine the treatment strategy for recurrent breast cancer, it is important to evaluate biopsies taken from different sites where the cancer has spread. Additionally, closely monitoring the tumor progression and treatment outcome is crucial in breast cancer patients. Radiogenomics and liquid biopsy are invasive tools that can provide valuable insights into the heterogeneity of breast cancer. (Less)
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Cancer of the Breast : Epidemiology, diagnostics and treatment - Epidemiology, diagnostics and treatment
editor
Kashyap, Dharambir ; Salman, Huda ; Sharma, Riya and Garg, Vivek Kumar
pages
89 - 112
publisher
Elsevier
external identifiers
  • scopus:85218368165
ISBN
978-0-443-24838-2
DOI
10.1016/B978-0-443-24838-2.00006-9
language
English
LU publication?
yes
id
2af250ef-3c0d-4ffa-b824-25d08e028864
date added to LUP
2025-02-05 11:35:38
date last changed
2025-06-30 11:02:08
@inbook{2af250ef-3c0d-4ffa-b824-25d08e028864,
  abstract     = {{Dealing with the heterogeneity of breast tumors and treating breast cancer patients pose a great challenge. The heterogeneity within and between tumors indicates that each case of breast cancer may have a good prognosis and could benefit from tailored therapies. Breast cancer is a condition that undergoes changes as the tumor progresses and metastasizes, which presents further challenges for implementing therapy decisions. To supplement existing information, we reflect on this contribution of breast cancer and its genetic heterogeneity at the single-cell level, providing a concise perspective of cellular architecture and taxonomy. Indeed, to determine the treatment strategy for recurrent breast cancer, it is important to evaluate biopsies taken from different sites where the cancer has spread. Additionally, closely monitoring the tumor progression and treatment outcome is crucial in breast cancer patients. Radiogenomics and liquid biopsy are invasive tools that can provide valuable insights into the heterogeneity of breast cancer.}},
  author       = {{Sharma, Riya and Parihar, Neha and Gopi, Keerti and Yadav, Vikas and Sharma, Pooja and Garg, Vivek Kumar and Okpala, Charles Odilichukwu R. and Buttar, Harpal Singh and Takur, Sheetal and Goel, Neelam and Kashyap, Dharambir}},
  booktitle    = {{Cancer of the Breast : Epidemiology, diagnostics and treatment}},
  editor       = {{Kashyap, Dharambir and Salman, Huda and Sharma, Riya and Garg, Vivek Kumar}},
  isbn         = {{978-0-443-24838-2}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{89--112}},
  publisher    = {{Elsevier}},
  title        = {{Breast cancer and its genetic heterogeneity at single cell level: A concise perspective of cellular architecture and taxonomy}},
  url          = {{http://dx.doi.org/10.1016/B978-0-443-24838-2.00006-9}},
  doi          = {{10.1016/B978-0-443-24838-2.00006-9}},
  year         = {{2025}},
}