Health Economic Analysis of Open and Robot-assisted Laparoscopic Surgery for Prostate Cancer Within the Prospective Multicentre LAPPRO Trial
(2018) In European Urology 74(6). p.816-824- Abstract
Background: The rapid adoption of robot-assisted laparoscopy in radical prostatectomy has preceded data regarding associated costs. Qualitative evidence regarding cost outcomes is lacking. Objective: This study assessed how costs were affected by robot-assisted laparoscopic prostatectomy (RALP) compared with open surgery. Design, setting, and participants: Cost analysis was based on the dataset of the LAPPRO (Laparoscopic Prostatectomy Robot Open) clinical trial, which is a prospective controlled, nonrandomised trial of patients who underwent prostatectomy at 14 centres in Sweden between September 2008 and November 2011. Currently, data are available from a follow-up period of 24 mo. Intervention: In the LAPPRO trial, RALP was compared... (More)
Background: The rapid adoption of robot-assisted laparoscopy in radical prostatectomy has preceded data regarding associated costs. Qualitative evidence regarding cost outcomes is lacking. Objective: This study assessed how costs were affected by robot-assisted laparoscopic prostatectomy (RALP) compared with open surgery. Design, setting, and participants: Cost analysis was based on the dataset of the LAPPRO (Laparoscopic Prostatectomy Robot Open) clinical trial, which is a prospective controlled, nonrandomised trial of patients who underwent prostatectomy at 14 centres in Sweden between September 2008 and November 2011. Currently, data are available from a follow-up period of 24 mo. Intervention: In the LAPPRO trial, RALP was compared with radical retropubic prostatectomy (RRP). Outcome measurements and statistical analysis: Costs per surgical technique were assessed based on resource variable data from the LAPPRO database. The calculation of average costs was based on mean values; Swedish currency was converted to purchasing power parity US dollar (PPP$). All tests were two-tailed and conducted at α = 0.05 significance level. Results and limitations: The cost analysis comprised 2638 men. Based on the LAPPRO trial data, RALP was associated with an increased cost/procedure of PPP$ 3837 (95% confidence interval: 2747–4928) compared with RRP. The result was sensitive to variations in caseload. Main drivers of overall cost were robotic system cost, operation time, length of stay, and sick leave. Limitations of the study include the uneven distribution between RALP and RRP regarding procedures in public/for-profit hospitals and surgeon/centre procedural volume. Conclusions: Based on the LAPPRO trial data, this study showed that RALP was associated with an increased cost compared with RRP in Swedish health care. There are many factors influencing the costs, making the absolute result dependent on the specific setting. However, by identifying the main cost drivers and/or most influential parameters, the study provides support for informed decisions and predictions. Patient summary: In this study, we looked at the cost outcome when performing prostatectomies by robot-assisted laparoscopic technique compared with open surgery in Sweden. We found that the robot-assisted procedure was associated with a higher mean cost. This cost analysis reports that compared with open surgery, robot-assisted laparoscopy for prostate cancer was associated with a net increase in cost. One important conclusion is that widespread implementation of costly new techniques should not precede outcomes from well-designed trials.
(Less)
- author
- organization
- publishing date
- 2018-08-22
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cost analysis, Health economics, Prostate cancer, Radical prostatectomy, Robot-assisted radical prostatectomy
- in
- European Urology
- volume
- 74
- issue
- 6
- pages
- 816 - 824
- publisher
- Elsevier
- external identifiers
-
- pmid:30143383
- scopus:85051824024
- ISSN
- 0302-2838
- DOI
- 10.1016/j.eururo.2018.07.038
- language
- English
- LU publication?
- yes
- id
- 2af430c4-14d1-4744-932d-1ce78691e320
- date added to LUP
- 2018-09-13 12:22:18
- date last changed
- 2024-04-15 12:35:48
@article{2af430c4-14d1-4744-932d-1ce78691e320,
abstract = {{<p>Background: The rapid adoption of robot-assisted laparoscopy in radical prostatectomy has preceded data regarding associated costs. Qualitative evidence regarding cost outcomes is lacking. Objective: This study assessed how costs were affected by robot-assisted laparoscopic prostatectomy (RALP) compared with open surgery. Design, setting, and participants: Cost analysis was based on the dataset of the LAPPRO (Laparoscopic Prostatectomy Robot Open) clinical trial, which is a prospective controlled, nonrandomised trial of patients who underwent prostatectomy at 14 centres in Sweden between September 2008 and November 2011. Currently, data are available from a follow-up period of 24 mo. Intervention: In the LAPPRO trial, RALP was compared with radical retropubic prostatectomy (RRP). Outcome measurements and statistical analysis: Costs per surgical technique were assessed based on resource variable data from the LAPPRO database. The calculation of average costs was based on mean values; Swedish currency was converted to purchasing power parity US dollar (PPP$). All tests were two-tailed and conducted at α = 0.05 significance level. Results and limitations: The cost analysis comprised 2638 men. Based on the LAPPRO trial data, RALP was associated with an increased cost/procedure of PPP$ 3837 (95% confidence interval: 2747–4928) compared with RRP. The result was sensitive to variations in caseload. Main drivers of overall cost were robotic system cost, operation time, length of stay, and sick leave. Limitations of the study include the uneven distribution between RALP and RRP regarding procedures in public/for-profit hospitals and surgeon/centre procedural volume. Conclusions: Based on the LAPPRO trial data, this study showed that RALP was associated with an increased cost compared with RRP in Swedish health care. There are many factors influencing the costs, making the absolute result dependent on the specific setting. However, by identifying the main cost drivers and/or most influential parameters, the study provides support for informed decisions and predictions. Patient summary: In this study, we looked at the cost outcome when performing prostatectomies by robot-assisted laparoscopic technique compared with open surgery in Sweden. We found that the robot-assisted procedure was associated with a higher mean cost. This cost analysis reports that compared with open surgery, robot-assisted laparoscopy for prostate cancer was associated with a net increase in cost. One important conclusion is that widespread implementation of costly new techniques should not precede outcomes from well-designed trials.</p>}},
author = {{Forsmark, Annabelle and Gehrman, Jacob and Angenete, Eva and Bjartell, Anders and Björholt, Ingela and Carlsson, Stefan and Hugosson, Jonas and Marlow, Tom and Stinesen-Kollberg, Karin and Stranne, Johan and Wallerstedt, Anna and Wiklund, Peter and Wilderäng, Ulrica and Haglind, Eva}},
issn = {{0302-2838}},
keywords = {{Cost analysis; Health economics; Prostate cancer; Radical prostatectomy; Robot-assisted radical prostatectomy}},
language = {{eng}},
month = {{08}},
number = {{6}},
pages = {{816--824}},
publisher = {{Elsevier}},
series = {{European Urology}},
title = {{Health Economic Analysis of Open and Robot-assisted Laparoscopic Surgery for Prostate Cancer Within the Prospective Multicentre LAPPRO Trial}},
url = {{http://dx.doi.org/10.1016/j.eururo.2018.07.038}},
doi = {{10.1016/j.eururo.2018.07.038}},
volume = {{74}},
year = {{2018}},
}