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Practice patterns and percutaneous coronary intervention outcomes : a comparison between Sweden and the US

Sampath-Kumar, Revathy ; Mohammad, Moman LU orcid ; von Koch, Sacharias LU orcid ; Reeves, Ryan ; Al Khiami, Belal ; Ang, Lawrence ; Melendez, Anna ; Mahmud, Ehtisham ; Ben-Yehuda, Ori and Erlinge, David LU orcid (2025) In European Heart Journal Open 5(3).
Abstract

AIMS: Comparisons of international practice patterns and their impact on percutaneous coronary intervention (PCI) outcomes are lacking. We compared temporal PCI trends between Sweden and a large university hospital system in the US.

METHODS AND RESULTS: Data within the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and the University of California San Diego Health internal National Cardiovascular Data Registry (NCDR) CathPCI Registry were used to identify patients who underwent PCI from 2007 to 2021. Baseline characteristics and practice patterns were assessed using all patients (275 021 Swedish cohort, 9883 US cohort). Mortality was analysed using a random-effects Cox model, restricted to patients treated at... (More)

AIMS: Comparisons of international practice patterns and their impact on percutaneous coronary intervention (PCI) outcomes are lacking. We compared temporal PCI trends between Sweden and a large university hospital system in the US.

METHODS AND RESULTS: Data within the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and the University of California San Diego Health internal National Cardiovascular Data Registry (NCDR) CathPCI Registry were used to identify patients who underwent PCI from 2007 to 2021. Baseline characteristics and practice patterns were assessed using all patients (275 021 Swedish cohort, 9883 US cohort). Mortality was analysed using a random-effects Cox model, restricted to patients treated at university hospitals and excluding those with cardiac arrest or cardiogenic shock (108 136 Swedish cohort, 9592 US cohort). The Swedish cohort was older, had a greater proportion of men, and was more likely to smoke (all P < 0.001). The US cohort had a higher body mass index and was more likely to have diabetes, hyperlipidaemia, prior PCI, congestive heart failure, and peripheral arterial disease (all P < 0.001). Sweden had lower rates of PCI for stable angina and lower use of mechanical circulatory support (all P < 0.001). More STEMI patients were treated with only heparin as anticoagulation in Sweden, even in the contemporary era. There was earlier adoption and increased utilization of ticagrelor and radial access in Sweden, while there was earlier use of drug-eluting stents in the US. Fractional flow reserve was used more frequently in Sweden. There was no difference in adjusted all-cause mortality 1 year post-PCI for any indication between university hospitals in Sweden and the US (hazard ratio [HR] 1.09; 95% CI 0.86-1.37; P = 0.48), and this finding was consistent across subgroups.

CONCLUSION: Despite significant differences in patient populations and practice variations, we found no difference in post-PCI mortality between university hospitals in Sweden and the US.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Heart Journal Open
volume
5
issue
3
article number
oeaf045
publisher
Oxford University Press
external identifiers
  • scopus:105004455456
  • pmid:40329990
ISSN
2752-4191
DOI
10.1093/ehjopen/oeaf045
language
English
LU publication?
yes
additional info
© The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.
id
2b57be42-01ab-42ff-bc9e-0f2cdcdfc99d
date added to LUP
2025-05-27 09:02:33
date last changed
2025-07-09 07:44:57
@article{2b57be42-01ab-42ff-bc9e-0f2cdcdfc99d,
  abstract     = {{<p>AIMS: Comparisons of international practice patterns and their impact on percutaneous coronary intervention (PCI) outcomes are lacking. We compared temporal PCI trends between Sweden and a large university hospital system in the US.</p><p>METHODS AND RESULTS: Data within the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and the University of California San Diego Health internal National Cardiovascular Data Registry (NCDR) CathPCI Registry were used to identify patients who underwent PCI from 2007 to 2021. Baseline characteristics and practice patterns were assessed using all patients (275 021 Swedish cohort, 9883 US cohort). Mortality was analysed using a random-effects Cox model, restricted to patients treated at university hospitals and excluding those with cardiac arrest or cardiogenic shock (108 136 Swedish cohort, 9592 US cohort). The Swedish cohort was older, had a greater proportion of men, and was more likely to smoke (all P &lt; 0.001). The US cohort had a higher body mass index and was more likely to have diabetes, hyperlipidaemia, prior PCI, congestive heart failure, and peripheral arterial disease (all P &lt; 0.001). Sweden had lower rates of PCI for stable angina and lower use of mechanical circulatory support (all P &lt; 0.001). More STEMI patients were treated with only heparin as anticoagulation in Sweden, even in the contemporary era. There was earlier adoption and increased utilization of ticagrelor and radial access in Sweden, while there was earlier use of drug-eluting stents in the US. Fractional flow reserve was used more frequently in Sweden. There was no difference in adjusted all-cause mortality 1 year post-PCI for any indication between university hospitals in Sweden and the US (hazard ratio [HR] 1.09; 95% CI 0.86-1.37; P = 0.48), and this finding was consistent across subgroups.</p><p>CONCLUSION: Despite significant differences in patient populations and practice variations, we found no difference in post-PCI mortality between university hospitals in Sweden and the US.</p>}},
  author       = {{Sampath-Kumar, Revathy and Mohammad, Moman and von Koch, Sacharias and Reeves, Ryan and Al Khiami, Belal and Ang, Lawrence and Melendez, Anna and Mahmud, Ehtisham and Ben-Yehuda, Ori and Erlinge, David}},
  issn         = {{2752-4191}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{Oxford University Press}},
  series       = {{European Heart Journal Open}},
  title        = {{Practice patterns and percutaneous coronary intervention outcomes : a comparison between Sweden and the US}},
  url          = {{http://dx.doi.org/10.1093/ehjopen/oeaf045}},
  doi          = {{10.1093/ehjopen/oeaf045}},
  volume       = {{5}},
  year         = {{2025}},
}