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Mitochondrial translation initiation machinery : Conservation and diversification

Kuzmenko, Anton ; Atkinson, Gemma C. LU ; Levitskii, Sergey ; Zenkin, Nikolay ; Tenson, Tanel ; Hauryliuk, Vasili LU orcid and Kamenski, Piotr (2014) In Biochimie 100(1). p.132-140
Abstract

The highly streamlined mitochondrial genome encodes almost exclusively a handful of transmembrane components of the respiratory chain complex. In order to ensure the correct assembly of the respiratory chain, the products of these genes must be produced in the correct stoichiometry and inserted into the membrane, posing a unique challenge to the mitochondrial translational system. In this review we describe the proteins orchestrating mitochondrial translation initiation: bacterial-like general initiation factors mIF2 and mIF3, as well as mitochondria-specific components - mRNA-specific translational activators and mRNA-nonspecific accessory initiation factors. We consider how the fast rate of evolution in these organelles has not only... (More)

The highly streamlined mitochondrial genome encodes almost exclusively a handful of transmembrane components of the respiratory chain complex. In order to ensure the correct assembly of the respiratory chain, the products of these genes must be produced in the correct stoichiometry and inserted into the membrane, posing a unique challenge to the mitochondrial translational system. In this review we describe the proteins orchestrating mitochondrial translation initiation: bacterial-like general initiation factors mIF2 and mIF3, as well as mitochondria-specific components - mRNA-specific translational activators and mRNA-nonspecific accessory initiation factors. We consider how the fast rate of evolution in these organelles has not only created a system that is divergent from that of its bacterial ancestors, but has led to a huge diversity in lineage specific mechanistic features of mitochondrial translation initiation among eukaryotes.

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Please use this url to cite or link to this publication:
author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
IF2, IF3, Mitochondria, Ribosome, Translational activators
in
Biochimie
volume
100
issue
1
pages
132 - 140
publisher
Elsevier
external identifiers
  • scopus:84897089274
  • pmid:23954798
ISSN
0300-9084
DOI
10.1016/j.biochi.2013.07.024
language
English
LU publication?
no
additional info
Funding Information: This work was supported by the funds from International Associated Laboratory “RNA-mitocure” (AK, SL, PK); Russian Foundation for Basic Research (AK, SL, PK) and Russian Ministry of Education and Science (AK, SL and PK); European Regional Development Fund through the Centre of Excellence in Chemical Biology (VH and TT), Estonian Science Foundation grants ( ETF9012 and PUT37 to VH, ETF9020 to GCA); Swedish Research council and Umeå University (VH); UK Biotechnology and Biosciences Research Council (NZ); European Research Council ( ERC-2007-StG 202994-MTP to NZ); Archimedes Foundation (AK) ; “U.M.N.I.K” program (AK) and European Social Fund grant “Mobilitas” MJD99 (GCA). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.
id
2bf5755c-5fff-4905-8df5-44621607d5bb
date added to LUP
2021-09-24 20:44:56
date last changed
2024-02-04 04:32:39
@article{2bf5755c-5fff-4905-8df5-44621607d5bb,
  abstract     = {{<p>The highly streamlined mitochondrial genome encodes almost exclusively a handful of transmembrane components of the respiratory chain complex. In order to ensure the correct assembly of the respiratory chain, the products of these genes must be produced in the correct stoichiometry and inserted into the membrane, posing a unique challenge to the mitochondrial translational system. In this review we describe the proteins orchestrating mitochondrial translation initiation: bacterial-like general initiation factors mIF2 and mIF3, as well as mitochondria-specific components - mRNA-specific translational activators and mRNA-nonspecific accessory initiation factors. We consider how the fast rate of evolution in these organelles has not only created a system that is divergent from that of its bacterial ancestors, but has led to a huge diversity in lineage specific mechanistic features of mitochondrial translation initiation among eukaryotes.</p>}},
  author       = {{Kuzmenko, Anton and Atkinson, Gemma C. and Levitskii, Sergey and Zenkin, Nikolay and Tenson, Tanel and Hauryliuk, Vasili and Kamenski, Piotr}},
  issn         = {{0300-9084}},
  keywords     = {{IF2; IF3; Mitochondria; Ribosome; Translational activators}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{132--140}},
  publisher    = {{Elsevier}},
  series       = {{Biochimie}},
  title        = {{Mitochondrial translation initiation machinery : Conservation and diversification}},
  url          = {{http://dx.doi.org/10.1016/j.biochi.2013.07.024}},
  doi          = {{10.1016/j.biochi.2013.07.024}},
  volume       = {{100}},
  year         = {{2014}},
}