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A sol-gel integrated dual-readout microarray platform for quantification and identification of prostate-specific antigen

Lee, S. W. LU ; Lee, J. H. ; Kwon, H. G. ; Laurell, T. LU ; Jeong, O. C. and Kim, S. (2018) 28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017 2018-January.
Abstract

Here, we report a sol-gel integrated affinity microarray for on-chip matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), which enables capture and identification of prostate-specific antigen (PSA) in samples. Protein microarray technologies, which involve miniaturizing spots of capture agents (such as antibody and aptamers) on a solid surface, enable multianalyte sensing and high-throughput analysis of protein-protein and protein-ligand interactions. This technique provides high-sensitivity analysis of biomarkers, as well as molecular profiling, and is thus used in the fields of life science, medicine and proteomics [1]. In clinical application, the high sensitive biomarker analysis enables early... (More)

Here, we report a sol-gel integrated affinity microarray for on-chip matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), which enables capture and identification of prostate-specific antigen (PSA) in samples. Protein microarray technologies, which involve miniaturizing spots of capture agents (such as antibody and aptamers) on a solid surface, enable multianalyte sensing and high-throughput analysis of protein-protein and protein-ligand interactions. This technique provides high-sensitivity analysis of biomarkers, as well as molecular profiling, and is thus used in the fields of life science, medicine and proteomics [1]. In clinical application, the high sensitive biomarker analysis enables early diagnosis, and prediction of prognosis and the response to treatment [2,3].

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author
; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science
volume
2018-January
pages
2 pages
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
conference name
28th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017
conference location
Nagoya, Japan
conference dates
2017-12-03 - 2017-12-06
external identifiers
  • scopus:85050544541
ISBN
9781538633144
DOI
10.1109/MHS.2017.8305253
language
English
LU publication?
yes
id
2d7c217e-c90f-42ee-bc4b-ee0266fded8a
date added to LUP
2018-09-18 12:04:54
date last changed
2022-05-03 06:06:24
@inproceedings{2d7c217e-c90f-42ee-bc4b-ee0266fded8a,
  abstract     = {{<p>Here, we report a sol-gel integrated affinity microarray for on-chip matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), which enables capture and identification of prostate-specific antigen (PSA) in samples. Protein microarray technologies, which involve miniaturizing spots of capture agents (such as antibody and aptamers) on a solid surface, enable multianalyte sensing and high-throughput analysis of protein-protein and protein-ligand interactions. This technique provides high-sensitivity analysis of biomarkers, as well as molecular profiling, and is thus used in the fields of life science, medicine and proteomics [1]. In clinical application, the high sensitive biomarker analysis enables early diagnosis, and prediction of prognosis and the response to treatment [2,3].</p>}},
  author       = {{Lee, S. W. and Lee, J. H. and Kwon, H. G. and Laurell, T. and Jeong, O. C. and Kim, S.}},
  booktitle    = {{MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science}},
  isbn         = {{9781538633144}},
  language     = {{eng}},
  month        = {{02}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  title        = {{A sol-gel integrated dual-readout microarray platform for quantification and identification of prostate-specific antigen}},
  url          = {{http://dx.doi.org/10.1109/MHS.2017.8305253}},
  doi          = {{10.1109/MHS.2017.8305253}},
  volume       = {{2018-January}},
  year         = {{2018}},
}