Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: The TRUFFLE 2 randomised trial protocol
(2022) In BMJ Open 12(4).- Abstract
- Introduction Following the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring invariably leading to delivery. Indices derived from fetal cerebral Doppler examination may guide such decisions although there are few studies in this area. We propose a randomised, controlled trial to establish the optimum method of timing delivery between 32 weeks and 36 weeks 6 days of gestation. We hypothesise that delivery on evidence of cerebral blood flow redistribution reduces a composite... (More)
- Introduction Following the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring invariably leading to delivery. Indices derived from fetal cerebral Doppler examination may guide such decisions although there are few studies in this area. We propose a randomised, controlled trial to establish the optimum method of timing delivery between 32 weeks and 36 weeks 6 days of gestation. We hypothesise that delivery on evidence of cerebral blood flow redistribution reduces a composite of perinatal poor outcome, death and short-term hypoxia-related morbidity, with no worsening of neurodevelopmental outcome at 2 years. Methods and analysis Women with non-anomalous singleton pregnancies 32+0 to 36+6 weeks of gestation in whom the estimated fetal weight or abdominal circumference is (Less)
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https://lup.lub.lu.se/record/2dfe30f7-e48e-4e56-89c3-d75624d9b123
- author
- Mylrea-Foley, B. ; Marsal, Karel LU and Lees, C.C.
- author collaboration
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- fetal medicine, maternal medicine, ultrasonography, abdominal circumference, Article, brain blood flow, cardiotocography, controlled study, Doppler flowmetry, female, fetus, fetus heart rate, fetus outcome, fetus weight, follow up, gestational age, human, hypoxia, middle cerebral artery, morbidity, nerve cell differentiation, newborn death, newborn morbidity, obstetric delivery, prematurity, pulsatility index, randomized controlled trial, umbilical artery, child, fetus echography, infant, intrauterine growth retardation, newborn, physiology, pregnancy, randomized controlled trial (topic), Cardiotocography, Child, Female, Fetal Growth Retardation, Fetal Weight, Heart Rate, Fetal, Humans, Infant, Infant, Newborn, Pregnancy, Premature Birth, Randomized Controlled Trials as Topic, Ultrasonography, Prenatal
- in
- BMJ Open
- volume
- 12
- issue
- 4
- article number
- e055543
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:85128487699
- pmid:35428631
- ISSN
- 2044-6055
- DOI
- 10.1136/bmjopen-2021-055543
- language
- English
- LU publication?
- yes
- id
- 2dfe30f7-e48e-4e56-89c3-d75624d9b123
- date added to LUP
- 2022-09-12 09:19:02
- date last changed
- 2022-09-13 03:00:06
@article{2dfe30f7-e48e-4e56-89c3-d75624d9b123,
abstract = {{Introduction Following the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring invariably leading to delivery. Indices derived from fetal cerebral Doppler examination may guide such decisions although there are few studies in this area. We propose a randomised, controlled trial to establish the optimum method of timing delivery between 32 weeks and 36 weeks 6 days of gestation. We hypothesise that delivery on evidence of cerebral blood flow redistribution reduces a composite of perinatal poor outcome, death and short-term hypoxia-related morbidity, with no worsening of neurodevelopmental outcome at 2 years. Methods and analysis Women with non-anomalous singleton pregnancies 32+0 to 36+6 weeks of gestation in whom the estimated fetal weight or abdominal circumference is}},
author = {{Mylrea-Foley, B. and Marsal, Karel and Lees, C.C.}},
issn = {{2044-6055}},
keywords = {{fetal medicine; maternal medicine; ultrasonography; abdominal circumference; Article; brain blood flow; cardiotocography; controlled study; Doppler flowmetry; female; fetus; fetus heart rate; fetus outcome; fetus weight; follow up; gestational age; human; hypoxia; middle cerebral artery; morbidity; nerve cell differentiation; newborn death; newborn morbidity; obstetric delivery; prematurity; pulsatility index; randomized controlled trial; umbilical artery; child; fetus echography; infant; intrauterine growth retardation; newborn; physiology; pregnancy; randomized controlled trial (topic); Cardiotocography; Child; Female; Fetal Growth Retardation; Fetal Weight; Heart Rate, Fetal; Humans; Infant; Infant, Newborn; Pregnancy; Premature Birth; Randomized Controlled Trials as Topic; Ultrasonography, Prenatal}},
language = {{eng}},
number = {{4}},
publisher = {{BMJ Publishing Group}},
series = {{BMJ Open}},
title = {{Perinatal and 2-year neurodevelopmental outcome in late preterm fetal compromise: The TRUFFLE 2 randomised trial protocol}},
url = {{http://dx.doi.org/10.1136/bmjopen-2021-055543}},
doi = {{10.1136/bmjopen-2021-055543}},
volume = {{12}},
year = {{2022}},
}