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Alpha-Ketoglutarate, the Bacteriome, Protein Metabolism, and Longevity

Pierzynowska, Kateryna LU orcid ; Wychowański, Piotr ; Dobrowolski, Piotr ; Donaldson, Janine and Pierzynowski, Stefan G. LU (2025) p.100-112
Abstract

Degenerative diseases related to aging, such as malnutrition, memory loss, and osteoporosis, develop due to a lack of appropriate components required at certain times for protein synthesis. Alpha-ketoglutarate (AKG) is produced by the gut bacteriome and regulates several processes involved in protein metabolism, but mainly ensures the sparing of host nitrogen (amine group) and the synthesis of new, diet-independent amino acids for host usage. To ensure healthy human aging and happy and productive longevity, one should consider supporting or preserving the primary source of AKG via feed supplementation and/or gut bacteriome revitalization/rejuvenation. The information presented in this chapter suggests that the primary component required... (More)

Degenerative diseases related to aging, such as malnutrition, memory loss, and osteoporosis, develop due to a lack of appropriate components required at certain times for protein synthesis. Alpha-ketoglutarate (AKG) is produced by the gut bacteriome and regulates several processes involved in protein metabolism, but mainly ensures the sparing of host nitrogen (amine group) and the synthesis of new, diet-independent amino acids for host usage. To ensure healthy human aging and happy and productive longevity, one should consider supporting or preserving the primary source of AKG via feed supplementation and/or gut bacteriome revitalization/rejuvenation. The information presented in this chapter suggests that the primary component required for tissue protein turnover and regeneration is AKG.

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Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Protein Intake in Health and Disease
pages
13 pages
publisher
CRC Press/Balkema
external identifiers
  • scopus:105012326317
ISBN
9781040356685
9781032458274
DOI
10.1201/b23328-8
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2026 Taylor & Francis Group, LLC.
id
302fddcd-c8c1-4229-98c0-672bd4611d72
date added to LUP
2026-01-21 15:39:11
date last changed
2026-01-26 09:59:23
@inbook{302fddcd-c8c1-4229-98c0-672bd4611d72,
  abstract     = {{<p>Degenerative diseases related to aging, such as malnutrition, memory loss, and osteoporosis, develop due to a lack of appropriate components required at certain times for protein synthesis. Alpha-ketoglutarate (AKG) is produced by the gut bacteriome and regulates several processes involved in protein metabolism, but mainly ensures the sparing of host nitrogen (amine group) and the synthesis of new, diet-independent amino acids for host usage. To ensure healthy human aging and happy and productive longevity, one should consider supporting or preserving the primary source of AKG via feed supplementation and/or gut bacteriome revitalization/rejuvenation. The information presented in this chapter suggests that the primary component required for tissue protein turnover and regeneration is AKG.</p>}},
  author       = {{Pierzynowska, Kateryna and Wychowański, Piotr and Dobrowolski, Piotr and Donaldson, Janine and Pierzynowski, Stefan G.}},
  booktitle    = {{Protein Intake in Health and Disease}},
  isbn         = {{9781040356685}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{100--112}},
  publisher    = {{CRC Press/Balkema}},
  title        = {{Alpha-Ketoglutarate, the Bacteriome, Protein Metabolism, and Longevity}},
  url          = {{http://dx.doi.org/10.1201/b23328-8}},
  doi          = {{10.1201/b23328-8}},
  year         = {{2025}},
}